Mental health research
Studies on depression, anxiety, ADHD, PTSD, bipolar disorder and more.
502 indexed studies · 288 currently recruiting
Top conditions in this hub
Recent studies
- RecruitingPHASE2
A Phase 2a Efficacy, Safety, Tolerability, and PK Study of SYT-510 in Participants With Generalized Anxiety Disorder
This study is testing a new medicine called SYT-510 for people with Generalised Anxiety Disorder (GAD). It's a short study looking at how safe and effective a single dose of SYT-510 is compared to a dummy pill.
United Kingdom - Enrolling by invitationPHASE3
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
This study looks at a new drug, LP352, for children and adults with a type of epilepsy called Developmental and Epileopathic Encephalopathy (DEE). It checks how safe and effective the drug is over a longer period for those who have already started treatment in previous studies.
United States · Australia · Belgium - Active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I5T-MC-AACQ: Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults with Early Symptomatic Alzheimer’s Disease
This study is looking at how different amounts of the drug donanemab affect swelling in the brain (ARIA-E) and reduce amyloid — a protein linked to Alzheimer's disease. It's for adults in the early stages of Alzheimer's.
Italy - Ongoing, recruitingPhase II and Phase III (Integrated)
A Randomized, Double-blind, Parallel-group, Placebo-controlled, Fixed-dose, Multicenter Study to Evaluate the Efficacy and Safety of SEP-363856 in Acutely Psychotic Patients with Schizophrenia, Followed by an Open-label Extension Phase
This study is looking at a new medicine called SEP-363856 for people who are currently experiencing severe symptoms of schizophrenia. We want to see if it helps reduce these symptoms and if it's safe to use. Some participants will get the new medicine, and others will get a dummy pill.
Romania - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to evaluate the effect of multiple doses of carbamazepine and itraconazole on how long JNJ-55308942 stays in the body (pharmacokinetics) in healthy adults.
This study is looking at how a new medicine, JNJ-55308942, moves through the body of healthy adults when taken with other common medicines. It's an early-stage study to understand how different medicines might affect each other, which is important for treating conditions like bipolar depression.
Belgium - Active not recruitingPHASE4
Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients
This study looks at whether a medicine called semaglutide (Wegovy®), along with healthy eating and exercise, can help people who have gained weight from certain mental health medications. It aims to reduce weight gain linked to antipsychotic treatment.
United Kingdom - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Study on the investigational drug IAMA-6, placebo-controlled, administered to healthy adult volunteers, at single oral doses and at multiple ascending oral doses to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics of IAMA-6 and its interaction with food
This early-stage study is testing a new medicine called IAMA-6 in healthy adults. Researchers want to see if it's safe, how the body handles it, and if food affects it. This is the very first time the medicine is being given to people.
Italy - RecruitingNA
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
This study looks at whether a special nutritional drink, 'Think Tank', can help middle-aged women aged 40-60 think more clearly after stressful experiences. Researchers will compare it to a dummy drink to see if it improves memory, attention, and overall well-being.
United Kingdom - Active not recruitingNA
Fibre and Mental Wellbeing Feasibility Trial
This study looks at whether eating an extra 10 grams of fibre daily for two weeks can improve how young adults aged 18-40 feel mentally. It focuses on sleep, anxiety, and stress to see if diet changes can boost well-being.
United Kingdom - Active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.
Argentina · Australia · China - Recruiting
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This study looks at how medical cannabis helps people in the UK with pain, sleep problems, anxiety, depression, or epilepsy. We want to see how well it works over time using patient feedback.
Canada - Active not recruitingNA
Video-Feedback Interaction Guidance for Improving Interactions Between Depressed Mothers and Their Infants ("VID-KIDS")
This study looks at a video-feedback program called VID-KIDS to help mothers with postnatal depression (PND) connect better with their babies. It aims to improve their interactions and measure if it also helps babies' stress and development.
Canada - RecruitingNA
Mechanisms Underlying Antidepressant Effects of Physical Activity
This study looks at how exercise helps people with depression. We want to understand what goes on in the body and brain when people exercise, to make exercise plans even better. Participants will do either aerobic exercise or stretching for 8 weeks.
United Kingdom - RecruitingPHASE4
"Extended" (Alternate Day) Antipsychotic Dosing
This study looks at whether taking antipsychotic medicine every other day works as well as taking it daily for conditions like schizophrenia. It also checks if this new schedule causes fewer side effects.
Canada - Enrolling by invitationNA
Increasing Physical Contact Between Prenatally Anxious/Depressed Mothers and Their Infants to Improve Maternal Sensitivity.
This study looks at whether anxious or depressed new mums find using a baby carrier helps them feel closer to their baby. It checks if this simple action can improve how mums bond with their newborns.
Canada - RecruitingPHASE4
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
This study looks at whether a medicine called metformin can help adults with learning disabilities who've gained weight from antipsychotic medicines. These medicines are important, but weight gain can lead to other health problems.
Canada - Recruiting
Prevalence of Postpartum Depression Among Patients of the CHUM GARE Clinic
This study looks at how common postnatal depression is in new mums at a special clinic. It also checks if a new screening method, using a questionnaire and a guide for doctors, can help find and support mums who need it.
Canada - RecruitingNA
Internet-delivered Cognitive Behaviour Therapy for Students: Duration Preference Trial
This study looks at online mental health courses for university and college students dealing with depression or anxiety. It compares different course lengths (fast, 5-week, or 8-week options) to see which ones students prefer and find most helpful for managing their feelings.
Canada - RecruitingNA
Brain-Oscillation Synchronized Stimulation of the DMPFC
This study looks at a new way to treat severe OCD using a special type of brain stimulation called rTMS. We're comparing whether personalising this treatment by using brain wave readings makes it more effective than the standard approach.
Canada - RecruitingNA
HELP (HEalthy Lifestyles Project) for Youth With Mental Distress
This study, called HELP, looks at how an online program can support young people aged 12-17 with mental health issues. It explores if the program improves emotional well-being and healthy habits like sleep and exercise, and if it reduces the need for mental health services.
Canada - Not yet recruitingPHASE3
Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder
This study looks into using a guided therapy with psilocybin (a compound from magic mushrooms) for people with Bipolar II Depression who haven't found other treatments helpful. We're testing if a single dose of psilocybin works better than a very low dose, alongside support from therapists.
Canada - RecruitingNA
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI
This study looks at whether a gentle electrical stimulation applied to the ear can help people with spinal cord injury who are also experiencing depression and inflammation. It aims to see if this treatment, called taVNS, can improve their mood and reduce body inflammation.
Canada - Not yet recruitingPHASE3
Sustained Mood Improvement With Laughing Gas Exposure
This study looks into whether laughing gas (nitrous oxide) can help improve mood in people with severe depression that hasn't responded to other treatments. It compares laughing gas to oxygen over four weeks.
Canada - RecruitingNA
Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression
This study looks at prescribing antidepressants for young people with anxiety or depression. It compares using a gene test to help choose medication versus standard prescribing. The aim is to see if the gene test leads to better results over 12 weeks.
Canada - RecruitingNA
Improving Patient Mental Health With Psychotherapist Virtual Training
This study tests new online training for therapists to help them understand patients better, especially those from different backgrounds. The goal is to improve therapy and patients' mental health by teaching therapists how to handle difficult moments in their conversations.
Canada - RecruitingNA
Internet-Delivered Cognitive Behaviour Therapy for Depression and Anxiety in Perinatal Parents
This study looks at an online therapy program for new and expecting parents feeling anxious or down. It checks how well this program, called the Wellbeing Course for New and Expecting Parents, helps parents and if it's easy to use. The program lasts 8 weeks.
Canada - Active not recruitingPHASE4
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
This study for adults with bipolar depression compares treatments like Cariprazine and combined Aripiprazole/Escitalopram. It looks at which medicines work best to help people get well and stay well over a year.
United States · Canada - RecruitingNA
Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
This study is looking at a new way to treat severe depression that hasn't responded to usual treatments. It uses a special helmet to send gentle sound waves to the brain, aiming to improve mood. We want to see if it's safe and helpful.
Canada - RecruitingNA
Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Frontline Health Care Workers (The HCW-CBTi Study)
This study looks at a digital program to help healthcare workers, especially those on the front lines during COVID-19, sleep better. It checks if this online therapy can improve their sleep, mental health, and overall well-being.
Canada - Not yet recruitingNA
Virtual Reality for Pain and Anxiety in Pediatric Dental Treatment
This study looks at whether using a special virtual reality (VR) headset can help children aged 6-12 feel less pain and worry during dental treatment. It compares VR to standard ways dentists already use to help children feel calm.
Canada - RecruitingNA
Technology in Play for Children With Physical Disabilities: the Dice Model of Play
This study looks at how children with and without physical or mental disabilities play. Researchers are using robots and other toys to understand play better and to help all children enjoy playing. They want to create a new model to explain play, making it easier for experts to help children.
Canada - Active not recruitingPHASE4
Epigenetic Health Benefits of Budesonide
This study looks at how a common nasal spray, budesonide, might help people with allergies. We want to see if it can reverse changes to our genes caused by allergens and pollution, which could lead to better allergy treatments.
Canada - Not yet recruitingNA
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression
This study aims to understand if depression is linked to a lack of a brain chemical called serotonin. Researchers will use special scans to see how serotonin levels change in people with depression compared to healthy volunteers, hoping to find better ways to treat depression.
United Kingdom - Active not recruitingNA
Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders
This study looks at a new online programme called RC2S+ for people with schizophrenia and similar conditions. It aims to see if using this programme distantly is practical and helpful for improving social thinking skills.
Canada - Not yet recruitingNA
Virtual Reality and Cranial Nerve Neuromodulation to Manage Chronic Pain
This study looks at using virtual reality (VR) and a new tongue stimulation method (Cranial Nerve Neuromodulation) to help Canadian military veterans with long-lasting pain and PTSD. It aims to see if combining these treatments works better than VR alone.
Canada - Not yet recruitingNA
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
This study looks at combining a special diet (ketogenic) with a brain stimulation treatment for people with depression that hasn't responded to other treatments. We want to see if this combination helps more than brain stimulation with a normal healthy diet.
Canada - Not yet recruitingPHASE1
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
This study looks at a new way to treat depression and extreme tiredness (fatigue) in people with Multiple Sclerosis (MS). It uses magnetic pulses to gently stimulate the brain. Researchers want to see if it's safe and helps improve mood and energy levels.
Canada - Active not recruitingNA
CAMH PARTNERs Integrated Care Study
This study looks at a new way to help people with depression, anxiety, or alcohol issues. It uses a special team and phone support to work with your family doctor. We want to see if this helps you feel better and improves your quality of life.
Canada - RecruitingNA
Evidence-based Internet Cognitive-behavioral Therapy for Social Anxiety
This study looks at how well an online therapy program called iCBT helps people in Canada with social anxiety. It checks if the program is effective, easy to use, and if people complete it. We want to make sure it works in real-life situations and can reach more people.
Canada