Neurology research
Parkinson's, Alzheimer's, multiple sclerosis, epilepsy and migraine research.
761 indexed studies · 354 currently recruiting
Top conditions in this hub
- Multiple Sclerosis76
- Parkinson Disease61
- Parkinson's disease46
- Dementia46
- Alzheimer Disease42
- Alzheimer's Disease33
- Epilepsy30
- migraine20
- Mild Cognitive Impairment12
- Huntington Disease12
- Relapsing Multiple Sclerosis10
- Neurodegenerative Diseases9
- Chronic Inflammatory Demyelinating Polyneuropathy8
- Multiple sclerosis (MS)8
- Chronic Migraine8
- Alzheimers Disease8
Recent studies
- Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study with a Long-Term Extension Treatment Period to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants with Early Alzheimer's Disease
This study is testing a new medicine, JNJ-63733657, for people with early Alzheimer's disease. Researchers want to see if it's safe and helps improve memory and thinking over two years, compared to a dummy drug.
Sweden · France · Belgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, randomized, double-blind, placebo-controlled, four-way cross-over study to evaluate the analgesic effects of TRV045 in healthy adults
This study is testing a new medicine, TRV045, to see if it can help with pain. It's a very early study in healthy adults, not patients, to understand how the medicine works in the body and if it's safe. Researchers are using a special light to create a small, temporary sunburn to measure pain.
Netherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized Phase 2 Study of Adjunctive EQU-001 for Uncontrolled Focal Onset Seizures
This study is testing a new medicine, EQU-001, for people with epilepsy whose seizures aren't fully controlled by their current treatment. It aims to see if the new medicine can reduce the number of seizures compared to a dummy medicine.
Sweden · Italy · France - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in Subjects With Parkinson’s Disease With a Pathogenic Variant in the Glucocerebrosidase (GBA1) Gene
This study is looking into a new medicine, BIA 28-6156, for people with Parkinson's disease linked to a specific gene change (GBA1). It wants to see if the medicine can slow down how the disease affects everyday activities and movement.
Germany · Netherlands · Sweden - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic Pain due to traumatic or post-operative peripheral Neuropathy
This study is looking at a new spray (AP707) for chronic pain caused by nerve damage after an injury or surgery. It aims to see how well it works and if it has side effects, compared to a dummy spray, for adults aged 18 and over.
Germany · Austria - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic pain due to central Neuropathy of any Genesis
This study is looking into a new spray (AP707) for people with long-term pain caused by nerve damage. It compares the spray to a dummy spray to see if it helps reduce pain over time. We want to know if it's safe and effective.
Austria · Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I5T-MC-AACQ: Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults with Early Symptomatic Alzheimer’s Disease
This study is looking at how different amounts of the drug donanemab affect swelling in the brain (ARIA-E) and reduce amyloid — a protein linked to Alzheimer's disease. It's for adults in the early stages of Alzheimer's.
Italy - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Open-Label, Follow-Up Study to Assess the Long-Term Use of Oral Lacosamide in Study Participants Who Completed EP0034 or SP848 and Received Lacosamide Treatment
This study is looking at the long-term safety and how well a medicine called lacosamide works for people with epilepsy. It's for those who have already taken lacosamide in previous studies and want to continue their treatment.
Hungary · Romania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and Tolerability of AP707 in Patients with chronic Pain due to Diabetic Polyneuropathy
This study is looking for new ways to help people with ongoing pain caused by diabetes affecting their nerves. It's testing a new spray treatment to see if it reduces pain and if it's safe compared to a dummy spray.
Austria · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-blind, Placebo-controlled, Dose-finding Study to Evaluate the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of ABBV-552 in Participants with Mild Alzheimer's Disease.
This study is testing a new medicine, ABBV-552, for people with mild Alzheimer's disease. Researchers want to see if it's safe, how well it works, and how the body handles it. They will compare different doses against a dummy medicine (placebo).
Germany · Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
SAD and MAD study of VES001
This early-stage study is looking at a new medicine called VES001 for a condition called Frontotemporal Dementia (FTD). It's the first time this medicine is being given to people, to check its safety and how it works in the body. Researchers want to see if it could help people with FTD in the future.
Netherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1b Study to Assess the Safety, Tolerability and Pharmacodynamics of PBFT02 in Adult Participants with Frontotemporal Dementia (FTD) and GRN or C9orf72 Mutations
This study is testing a new medicine, PBFT02, for people with a type of dementia called Frontotemporal Dementia (FTD). Researchers want to see if it's safe, how well people tolerate it, and how it affects the body, specifically for those with certain gene changes (GRN or C9orf72).
Portugal · Spain - Recruiting
Mobilise-D: Extension Study
This study looks at how Parkinson's disease affects movement and how our movement changes as we get older. Researchers will use a special device to track how people move, hoping to understand the condition better and improve ways to measure it in daily life.
United Kingdom - Active not recruitingPHASE2
To Assess Efficacy and Safety of Batoclimab in Adult Participants With Active CIDP
This study is testing a new drug called batoclimab for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see how well it works and if it's safe compared to a dummy drug.
United States · Argentina · Belgium - Recruiting
Product Surveillance Registry
This study keeps track of how well Medtronic medical devices, like those for heart problems or other conditions, work in real life. It aims to make sure these devices are safe and effective for patients.
United States · Argentina · Australia - RecruitingPHASE3
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
This study looks at the long-term safety of a new medicine, KarXT, for people with changes in their thoughts and feelings due to Alzheimer's disease. Participants have already taken part in similar studies and will continue to be monitored for about a year.
United States · Argentina · Belgium - Active not recruitingPHASE3
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)
This study is looking at a new medicine called remibrutinib for people with relapsing multiple sclerosis (RMS). It compares remibrutinib to an existing medicine, teriflunomide, to see how well it works and if it's safe. It's a large study, involving about 800 people.
United States · Argentina · Brazil - Active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.
Argentina · Australia · China - Active not recruitingPHASE3
Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine
This study compares two medicines, atogepant and topiramate, for preventing migraine headaches. Researchers want to see which medicine causes fewer side effects in adults with migraines. It involves taking pills and having regular check-ups over a long period.
Austria · Belgium · Canada - Not yet recruiting
Local Field Potential Correlates of Neuropsychiatric Symptoms in Parkinson's Disease
This study looks at brain signals in people with Parkinson's and a special brain implant. We want to see if these signals are linked to problems like anxiety, urges, or seeing things. This could help us understand these issues better.
China · United Kingdom - RecruitingNA
GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
This study looks at a new brain implant called N1 and a robot, R1, for people with paralysis. It aims to see if they are safe and can help control devices like computers, offering a new way to interact with the world.
United Kingdom - Enrolling by invitation
An Observational Study of Patients With Moderate Parkinson's Disease
This study watches people with moderate Parkinson's disease to see how their symptoms change over time. Participants continue their usual medicine, but doctors might suggest adjustments. It helps us understand the condition better.
United States · Japan · Sweden - Recruiting
Non-invasive Detection of Volatile Metabolites in Parkinson's Disease
This study is looking for a new, simple way to diagnose Parkinson's disease earlier. Researchers are checking if a breath test can spot early signs of the condition by looking at tiny molecules in your breath, combined with changes in gut bacteria.
United Kingdom - RecruitingPHASE3
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
This study is looking into a new treatment called KarXT + KarX-EC for agitation (feeling restless or upset) in people with Alzheimer's disease. It wants to see if the treatment is safe and if it helps reduce agitation.
United States · Argentina · Chile - Recruiting
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This study looks at how medical cannabis helps people in the UK with pain, sleep problems, anxiety, depression, or epilepsy. We want to see how well it works over time using patient feedback.
Canada - RecruitingPHASE2
IMPACT 360 for Parkinson's Disease
This study called IMPACT 360 looks at how exercise, mindfulness, and healthy eating might help people with Parkinson's and a sleep disorder called RBD. It aims to improve health and understand why these changes happen.
Canada - Active not recruitingPHASE2
Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
This study is testing a new treatment, LY3848575, for nerve pain that starts in the feet and moves up the legs. Researchers want to see if it's safe and helps reduce pain compared to a dummy treatment.
United States · Canada · Germany - Not yet recruitingPHASE2
Evaluation of the Safety and Efficacy of NeuroEPO in Subjects With Mild to Moderate Alzheimer's Disease
This study is testing a new medicine, NeuroEPO, for people with mild to moderate Alzheimer's disease. Researchers want to see if it helps brains work better or stops them getting worse over a year. They also want to check for any side effects. Half the people will get NeuroEPO, and half will get a dummy medicine.
Canada - Active not recruiting
Noninterventional Study Evaluating Parkinson's Disease Diary Use
This study looks at the best way for people with Parkinson's disease to use a special diary. It checks if using the diary more often or less often makes a difference in how well it shows their symptoms. This helps understand how their Parkinson's changes over time.
United States · Canada · Germany - RecruitingNA
EMG Biofeedback Training to Improve Balance in Individuals with Multiple Sclerosis
This study looks at a new training method called EMG Biofeedback, using sensors, to help people with multiple sclerosis improve their balance. It compares it to traditional exercises to see which works best and if the improvements last.
Canada - RecruitingNA
CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders
This study aims to improve how older people with memory problems, like Alzheimer's, move between different healthcare services in Quebec, Canada. It's testing a special program to make care smoother and better for patients and their families.
Canada - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Multi-Cohort, Open-Label, Randomized Pilot Study to Evaluate the Effect of Food and a Proton-Pump Inhibitor (esomeprazole) on the Single-Dose Pharmacokinetics of ARV-102 in Healthy Participants.
This study is looking at a new medicine called ARV-102 for Parkinsonian syndromes. It wants to see how food and another common stomach medicine (esomeprazole) affect how ARV-102 works in healthy people.
Netherlands - Not yet recruitingNA
FIT-ATOMIC Exercise Feasibility Trial
This study looks at a 20-week home exercise programme for young people aged 11-25 with Multiple Sclerosis (MS). It aims to see if this type of exercise is a good way to help manage MS and improve their health, preparing for a larger study.
United States · Canada - RecruitingPHASE2
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
This study is looking at a new way to help people with Alzheimer's disease who feel unmotivated or apathetic. It combines a brain stimulation method with a commonly used medicine to see if it can improve these feelings.
Canada - Active not recruitingNA
A Virtual Reality at Home Intervention for People Living With Dementia
This study looks at how virtual reality (VR) and tablets can help people with dementia and their family carers communicate better at home. It checks if VR, or just a tablet, improves their conversations and lives together.
Canada - Recruiting
Seizure Recurrence After Unprovoked First Seizure
This study aims to understand why some people have another seizure after their first one. Researchers will use special brain scans and tests to predict who is most likely to have more seizures, helping doctors decide if treatment is needed sooner.
Canada - RecruitingNA
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
This study looks at a special type of brain stimulation, called Deep TMS, for people over 60 with both depression and early Alzheimer's or memory problems. It's for those whose depression hasn't improved with usual treatments. We want to see if it's safe and helps with mood.
Canada - Not yet recruiting
Artificial Intelligence-based Parkinson's Disease Risk Assessment (AI-PRA) Study
This study is using smartwatches, phone apps, and AI to estimate a person's risk of Parkinson's disease early. It's for people aged 50 or over who are at risk of Parkinson's but don't have a diagnosis yet. The goal is to find ways to spot the disease sooner.
France · Spain · United Kingdom - Active not recruiting
Validation and Standardization of Paramagnetic Rim Lesion (PRL) Identification in Multiple Sclerosis Across MAGNIMS Centers
This study looks at how consistently special brain scans (MRIs) are read across different hospitals for people with Multiple Sclerosis (MS). It aims to make sure everyone agrees on identifying specific 'rim lesions' in MS to help improve diagnosis and treatment plans for patients, using existing scan data only.
Austria · Czechia · Denmark - RecruitingNA
Exercise to Improve Sleep in Parkinson's Disease
This study looks at how different types of exercise – cardio, strength, or a mix – can improve sleep for people with Parkinson's disease. Researchers want to see if better sleep also improves their quality of life.
Canada