Respiratory health research
Asthma, COPD, cystic fibrosis and sleep-related breathing studies.
851 indexed studies · 404 currently recruiting
Top conditions in this hub
- Asthma76
- Chronic Obstructive Pulmonary Disease39
- Cystic Fibrosis39
- COPD31
- Chronic Obstructive Pulmonary Disease (COPD)30
- Idiopathic Pulmonary Fibrosis28
- Pulmonary Arterial Hypertension26
- Pulmonary Hypertension22
- Obstructive Sleep Apnea18
- Acute Respiratory Distress Syndrome17
- Pulmonary Embolism14
- Respiratory Failure13
- COPD (Chronic Obstructive Pulmonary Disease)13
- Severe Asthma12
- Sleep Apnea10
- Cystic Fibrosis (CF)10
Recent studies
- RecruitingPHASE2
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
This study is looking into a new drug, AZD8965, for people with Idiopathic Pulmonary Fibrosis (IPF). It aims to see if different doses of this drug are safe and effective, compared to a dummy drug, for people with IPF, including those already on other treatments.
United States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
This study looks at the long-term safety of a treatment called astegolimab for people with a lung condition called COPD. It's for people who have already taken part in previous studies of this drug.
United States · Argentina · Australia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) with a History of Exacerbations (PROSPERO)
This study is testing a new medicine called Tozorakimab for people with severe COPD. It aims to see if Tozorakimab can reduce flare-ups and is safe to use long-term, compared to a dummy medicine.
Sweden · Romania · Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to learn how safe the study treatment BAY2701250 is, how it affects the body and how it moves into, through and out of the body in healthy male participants when a single amount is given as an injection into the vein (intravenous infusion) or under the skin (subcutaneous injection).
This study is looking at a new medicine called BAY2701250 for a heart and lung condition. We want to see how safe it is and how it works in the body. Healthy men will receive a single dose, either as an injection into a vein or under the skin.
Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. -AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
This study looks at how morphine, a painkiller, works in people with obesity and sleep apnoea compared to healthy volunteers. We want to understand if these conditions change how the body handles morphine to make sure it's used safely and effectively.
Denmark - Ongoing, recruitingTherapeutic use (Phase IV)
Symptoms control and adhErenCe assessment during treatment with mepolizUmab new pREfilled devices. SECURE
This study looks at how well people with asthma use their medication (Mepolizumab) and how much it helps control their symptoms over six months. It compares different ways of giving the medication, looking at patient diaries and pharmacy records.
France - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)
This study is testing a new medicine, AZD3427, for people with heart failure and high blood pressure in the lungs caused by heart problems. We want to see if it improves how the heart and lungs work together.
Denmark · Poland · Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ASTEGOLIMAB IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
This study is testing a new medicine, astegolimab, for people with a lung condition called COPD. It wants to see if this medicine can help reduce flare-ups (exacerbations) of COPD and if it's safe to use. You might get the new medicine or a dummy medicine.
Hungary · Greece · Spain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
COTRIVAP - Efficacy of cotrimoxazole as a de-escalation treatment of Ventilator-Associated Pneumonia in intensive care unit. Multicentric non-inferiority randomised controlled trial
This study is looking at whether a common antibiotic, co-trimoxazole, can be used to treat pneumonia in patients on a ventilator in intensive care. It compares it to standard treatments to see if it works just as well and is safe.
France - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
RANDOMISED, CROSSOVER BIOEQUIVALENCE CLINICAL TRIAL OF MONTELUKAST 10 MG CAPSULES VS MONTELUKAST 10 MG FILM-COATED TABLETS, AFTER A SINGLE ORAL DOSE ADMINISTRATION TO HEALTHY VOLUNTEERS UNDER FASTING CONDITIONS.
This study is comparing two ways of taking the asthma medicine montelukast: a capsule and a film-coated tablet. We want to see if the body uses them in the same way when taken by healthy people who haven't eaten, to make sure they work equally well.
Spain - Ongoing, recruitingPhase III and phase IV (Integrated)
A Double Blind, Multicentre, Randomised Three-Period, Three-Treatment, Cross-Over Study To Evaluate The Effect of BGF MDI, BFF MDI and Placebo MDI on Exercise Parameters In Participants with Chronic Obstructive Pulmonary Disease (ATHLOS)
This study is looking at a new inhaler treatment called Trixeo Aerosphere for people with a lung condition called Chronic Obstructive Pulmonary Disease (COPD). It compares it to another inhaler and a dummy inhaler to see if it helps people exercise more easily.
Germany · Spain - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
An open-label, healthy subject, two-part study to assess the effect of verapamil on systemic exposure of EP395 (Part A), and to assess the effect of EP395 on systemic exposure of midazolam and digoxin (Part B)
This study is looking at how two medicines, EP395 and verapamil, affect each other in healthy people. It also checks how EP395 affects other common medicines like midazolam and digoxin. The aim is to understand how these drugs behave in the body.
Sweden - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 study to evaluate the efficacy and safety of RPT193 in adults with moderate-to-severe T2-high asthma who are partially controlled on inhaled corticosteroid and long-acting beta 2 agonist therapy
This study is testing a new medicine, RPT193, for adults with moderate to severe asthma that's not fully controlled by their usual inhalers. It aims to see how well RPT193 works and if it's safe, helping researchers understand if it could be a future treatment option.
Czechia · Bulgaria · Poland - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A clinical study investigating OM-85-IN safety and tolerability in healthy volunteers and mild allergic asthma patients
This study is looking into a new treatment called OM-85-IN. It's designed for people with mild allergic asthma, as well as healthy volunteers. The main goal is to check if it's safe and how well people tolerate it, which means seeing if it causes any unwanted effects.
Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 52-week, randomised, double blind, multicentre, 2-arm parallel group trial assessing the efficacy and safety of CHF6001 (total daily dose 3200 μg) Dry Powder Inhaler (DPI) add-on to maintenance medium or high dose inhaled corticosteroid in combination with long-acting ß2-agonists in subjects with uncontrolled asthma
This study looks at a new inhaler, CHF6001, for people with asthma that isn't fully controlled. Researchers want to see if adding this new inhaler to their usual medication helps reduce asthma attacks over 52 weeks and is safe.
Italy · Spain · Czechia - Recruiting
Exploring the Lived Experience of Young Adults With Severe Asthma
This study explores the daily experiences of young adults (16-25) with severe or uncontrolled asthma in Manchester and Liverpool. We aim to understand their challenges and needs to improve future care and support for this group, which is often overlooked.
United Kingdom - Active not recruitingPHASE3
Clinical Trial of Inhaled Molgramostim Nebulizer Solution in Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
This study looks at a new inhaled medicine, molgramostim, for a rare lung condition called autoimmune pulmonary alveolar proteinosis (aPAP). We want to see if it helps patients better than a dummy treatment. After 48 weeks, everyone gets the active medicine.
United States · Australia · Belgium - RecruitingPHASE2
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
This study is for adults with certain advanced cancers, including small cell lung cancer. It tests a new treatment called BI 764532 to see if different doses are safe and can shrink tumours. Sometimes, this treatment is called obrixtamig.
United States · Belgium · Bulgaria - RecruitingPHASE3
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
This study looks at a new medicine called Tozorakimab. We want to see if it can help people in hospital with lung infections who need extra oxygen. The goal is to stop them from getting sicker, like needing a breathing machine, or even dying.
United States · Argentina · Australia - Recruiting
Product Surveillance Registry
This study keeps track of how well Medtronic medical devices, like those for heart problems or other conditions, work in real life. It aims to make sure these devices are safe and effective for patients.
United States · Argentina · Australia - RecruitingPHASE3
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
This study looks at a new treatment called benralizumab for people with severe asthma. It compares adding benralizumab to your usual asthma inhaler with just increasing the dose of your inhaler. We want to see if benralizumab helps control asthma better and is safe.
United States · Bulgaria · Canada - RecruitingNA
Long-term Evaluation of the SIMEOX Device at Home in Non-cystic Fibrosis Bronchiectasis
This study looks at how a device called SIMEOX, used at home, might help people with a lung condition called non-cystic fibrosis bronchiectasis. Researchers want to see if it improves their quality of life and reduces flare-ups over a long time, compared to standard care.
France · Germany · Poland - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
This study is testing a new medicine, tezepelumab, for adults with moderate to very severe COPD. It wants to see if the medicine helps improve their breathing and overall health, and if it's safe to use.
United States · Brazil · Canada - Not yet recruitingNA
Feasibility of Protocolised Analgosedation in ECMO
This study looks at whether a special plan for giving painkillers and sedatives (drugs to help you relax) to very sick patients on a life support machine called ECMO could lead to better long-term health. It's testing if such a study is possible to run.
United Kingdom - Enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
efficacy and safety of the use of regulatory T cells in immune hyperactivation in patients with COVID-19 and/or acute respiratory distress syndrome
This study is looking at a new treatment involving special immune cells for people very sick with COVID-19 or a severe lung problem called ARDS. It aims to see if this treatment is safe and helps calm down an overactive immune system, which can make these illnesses worse.
Spain - RecruitingNA
VentilO Prospective Study
This study compares two ways to set up breathing machines for adults in intensive care after heart surgery. It checks if using a special app, VentilO, makes a difference compared to doctors choosing the settings. We want to see if one method leads to fewer breathing problems called acidosis.
Canada - RecruitingNA
Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer.
This study looks at how well a special mouthguard, called a Mandibular Advancement Device (MAD), works to help people with throat cancer who snore or stop breathing in their sleep. It checks if the device is comfortable and helpful.
Canada - Not yet recruitingNA
REverse LuNg Airway and Vascular RemOdeling in Asthma ReMission (ReNORM)
This study looks at how new asthma medicines (biologics) change the lungs of adults with severe asthma. Researchers want to see if these treatments can reverse lung damage, and if age makes a difference. It involves lung scans and breath tests.
Canada - RecruitingNA
Streamlined Treatment of Pulmonary Exacerbations in Pediatrics
This study looks at two ways to treat lung flare-ups (exacerbations) in children with Cystic Fibrosis. It compares immediate antibiotics to a 'watch and wait' approach to see which is safer and works better long-term, and if we can use fewer antibiotics.
United States · Canada - Active not recruitingNA
Low-Flow vs. High-Flow Nasal Cannula for Hypoxemic Immunocompromised Patients During Diagnostic Bronchoscopy
This study compares two ways of giving oxygen through the nose during a medical test called a bronchoscopy. It looks at whether using a device called 'Optiflow' to give more oxygen can stop oxygen levels from dropping in patients who have a weakened immune system and a lung infection.
Canada - Recruiting
Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)
This study uses new MRI scans to better understand why some premature babies develop lung problems. We want to find early signs of lung disease so doctors can help these babies sooner and find new ways to treat them. It involves babies born very early, looking at their lungs and hearts.
Canada - Recruiting
Trikafta Exercise Study in Cystic Fibrosis
This study looks at how a cystic fibrosis (CF) drug called Trikafta affects shortness of breath and exercise ability. Researchers want to see if Trikafta helps people with CF exercise more easily and feel less breathless, which could improve their overall health.
Canada - RecruitingNA
The Effects of Oscillatory Positive Expiratory Pressure (OPEP) Therapy in Patients With COPD
This study looks at whether a special breathing device called OPEP can help people with COPD breathe better and cough less. Participants will use the device at home for four weeks, and researchers will compare their breathing and cough symptoms before and after.
Canada - RecruitingPHASE3
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This study is testing a new medicine, Maridebart Cafraglutide, for adults with sleep apnea who use a CPAP machine and are also overweight or have obesity. We want to see if the medicine helps improve their sleep apnea and is safe to use over 52 weeks.
United States · Australia · Brazil - Not yet recruiting
The Effectiveness of Early Immunisation With Nirsevimab on Preschool Wheezing in France, Based on an Analysis of Data From the French Health System Database.
This study looks at whether a special injection called nirsevimab, given early in life, helps prevent young children in France from getting wheezing problems. Researchers are using existing health records to see if babies who received this injection end up in hospital less often for wheezing as toddlers and preschoolers.
France - RecruitingPHASE2
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
This study uses special MRI scans with safe gases to look at lungs in people with cystic fibrosis and asthma, and healthy volunteers. The aim is to see how well these new scanning methods work and what they can tell us about lung health.
Canada - Active not recruiting
Is Hypoxemia Driving Outcome in Acute Hypoxemic Respiratory Failure? (HOMELAND Study)
This study looks at health information from over a thousand patients in Spain who had severe breathing problems. Researchers want to understand why some patients get worse and how low oxygen levels might affect their chances of survival in intensive care.
Spain · United Kingdom - RecruitingNA
My Lung Health Coach-A Virtual COPD Self-management Support Program Integrated Into the Electronic Patient Record
This study looks at a 12-week online coaching program called 'My Lung Health Coach' for people with COPD. It helps you manage your condition with tips on things like breathing, exercise, and medicines. We also check out a special app that works with the program.
Canada - RecruitingNA
Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI
This study looks at how CPAP therapy helps people with spinal cord injuries who also have breathing problems during sleep. It aims to see if CPAP can improve tiredness, mood, and thinking skills, and overall quality of life.
Canada