Weight management research
Obesity, GLP-1 medicines, bariatric and lifestyle intervention studies.
287 indexed studies · 157 currently recruiting
Top conditions in this hub
- Obesity132
- Overweight33
- Obesity & Overweight17
- Metabolic Syndrome15
- Type 2 Diabetes15
- Overweight and Obesity12
- Diabetes Mellitus, Type 29
- Diabetes8
- Cardiovascular Diseases8
- Hypertension7
- Bariatric Surgery Candidate7
- Bariatric Surgery6
- Healthy6
- Diabetes Mellitus5
- Weight Loss5
- Obesity and Obesity-related Medical Conditions4
Recent studies
- RecruitingPHASE3
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
This study is looking at a new medicine called KAI-9531. It aims to see if weekly injections of this medicine can help people who are overweight or obese, and have other health issues related to their weight, lose weight. We want to know if it's safe and effective.
United States · Argentina · Australia - Not yet recruitingNA
Glycaemic Response of Arabic Bread
This study is looking at how different types of Arabic bread, made with chickpea, pea, or lentil flour, affect blood sugar levels. They want to see if these breads can help keep blood sugar more steady compared to regular wheat bread in people who are overweight or have obesity.
United Kingdom - Ongoing, recruitingTherapeutic exploratory (Phase II)
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. -AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
This study looks at how morphine, a painkiller, works in people with obesity and sleep apnoea compared to healthy volunteers. We want to understand if these conditions change how the body handles morphine to make sure it's used safely and effectively.
Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesity or Overweight with Weight-Related Comorbidities
This study is comparing two medicines, Tirzepatide and Semaglutide, to see which is more effective and safer for helping adults with obesity or overweight, who also have other health issues, to lose weight. It's looking at how much weight people lose and other health changes.
Germany · Belgium · Poland - AuthorisedTherapeutic confirmatory (Phase III)
The effect of semaglutide therapy on hepatic fat content and on the acute reponse of liver fat to high-fat load in obese MASLD patients
This study looks at how a medicine called semaglutide affects fat in the liver of men with obesity and a condition called MASLD. We want to see if it reduces liver fat and how the liver responds to fatty foods after taking the medicine.
Czechia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J1I-MC-GZBK: A Master Protocol to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants with Type 2 Diabetes Mellitus Who Have Obesity or Overweight: A Randomized Double-Blind, Placebo-Controlled Trial (TRIUMPH-2)
This study is looking into a new weekly injection called Retatrutide. It's for people with type 2 diabetes who are also overweight or obese. The main goal is to see how well it helps with weight loss compared to a dummy injection (placebo).
Spain · Romania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J1I-MC-GZBM: A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants with Severe Obesity and Established Cardiovascular Disease (TRIUMPH-3)
This study is looking into a new weekly injection called Retatrutide. We want to see if it helps people with severe obesity and heart problems lose weight safely. It's compared to a dummy injection to see how well it works.
Slovakia · Hungary · Spain - Active not recruitingPHASE4
Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients
This study looks at whether a medicine called semaglutide (Wegovy®), along with healthy eating and exercise, can help people who have gained weight from certain mental health medications. It aims to reduce weight gain linked to antipsychotic treatment.
United Kingdom - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A randomised, placebo-controlled, double-blinded, cross-over, Phase 1 study evaluating the safety and preliminary efficacy of the GLP 1 analogue ROSE-010 on appetite and food intake in overweight and obese subjects.
This study is testing a new medicine, ROSE-010, for people who are overweight or obese. It's a very early study looking at whether the medicine is safe and if it helps reduce appetite and how much food people eat.
Sweden - RecruitingNA
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
This study compares an intensive diet and lifestyle programme with weight-loss surgery for adults with severe obesity. We want to see which method works best and is safest, to help improve future treatment options.
Denmark · United Kingdom - RecruitingPHASE3
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
This study looks at a new medicine called Setmelanotide for children and adults aged 4 and over with a certain type of obesity called hypothalamic obesity. Researchers want to see if it helps with weight, hunger, and quality of life.
United States · United Kingdom - Recruiting
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
This study looks at how weight loss surgery (sleeve gastrectomy) affects bones and muscles in men, and women before and after menopause. It compares people who have the surgery with those who don't, to understand its long-term effects on bone strength and muscle mass.
Canada - Active not recruitingNA
Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
This study looks at how different types of soft drinks – regular sugary ones, diet ones, and those sweetened with stevia – affect your health. Researchers want to understand if these drinks change the helpful bacteria in your gut and impact your body's metabolism over 10 weeks.
Canada - RecruitingPHASE4
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
This study looks at whether a medicine called metformin can help adults with learning disabilities who've gained weight from antipsychotic medicines. These medicines are important, but weight gain can lead to other health problems.
Canada - Active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - Recruiting
Visceral Adipose Tissue and Liver Changes Associated With Semaglutide in CKD
This study looks at how a drug called semaglutide affects body fat and the liver in people with type 2 diabetes and kidney disease. It aims to understand how this medication helps improve health by looking closely at fat tissue.
Canada - Active not recruitingNA
Effect of Raspberry on Gut Microbiota and Metabolic Syndrome
This study looks at how raspberry supplements might improve health by changing the tiny germs in our gut. We want to see if raspberries can help people struggling with weight and other related health issues by positively affecting their gut bacteria.
Canada - RecruitingPHASE3
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This study is testing a new medicine, Maridebart Cafraglutide, for adults with sleep apnea who use a CPAP machine and are also overweight or have obesity. We want to see if the medicine helps improve their sleep apnea and is safe to use over 52 weeks.
United States · Australia · Brazil - RecruitingEARLY_PHASE1
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
This study looks at whether apple cider vinegar can increase beneficial gut bacteria in men with prostate cancer starting hormone therapy. Researchers want to see if this helps reduce side effects like weight gain and diabetes, which can be linked to their treatment.
Canada - Active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - RecruitingPHASE3
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study looks at a new medicine, NNC0487-0111, for people who are overweight and have knee pain from arthritis. It wants to see if this medicine helps with losing weight and reducing pain compared to a dummy medicine.
United States · Australia · Bulgaria - Active not recruitingNA
Childhood Obesity Management Using Innovative Digital Technology
This study looks at a 10-week online program called the Family Healthy Living Program (FHLP) for families with children aged 8-12 who are at risk of being overweight. It compares this program to simply providing online healthy living materials to see which works better.
Canada - RecruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
This study looks at a new medicine called retatrutide for people who are overweight or have obesity and suffer from long-term lower back pain. It aims to see if the medicine helps ease their pain and if it's safe to use.
United States · Argentina · Canada - RecruitingPHASE3
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
This study is testing a new medicine, Ribupatide, for people who are overweight or have obesity and also have type 2 diabetes. It aims to see if Ribupatide helps with weight loss and improves blood sugar levels compared to a dummy medicine.
United States · Argentina · Australia - RecruitingPHASE4
Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet
This study looks at whether a drug called Naltrexone/Bupropion, when taken after weight-loss surgery (sleeve gastrectomy), helps people lose more weight, improve health problems linked to obesity, and change eating habits. It compares the drug to a dummy pill.
Canada - Active not recruitingPHASE1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
This study looks at a new drug, RO7204239, for people with type 2 diabetes who are overweight or have obesity. It aims to see if the drug can improve how the body uses insulin and affects muscle health. This is an early stage study.
Germany - Not yet recruitingNA
Multicentric Approval Study Trans-Duodenal Barrier for Typ 2 Diabetes With Obesity
This study checks a new internal device, the Trans-Duodenal Barrier, for safety and effectiveness in adults with type 2 diabetes and obesity. It's a temporary implant to see if it helps lower blood sugar and reduce weight.
Germany - Recruiting
How Metabolism Affects Weight Loss and Gain
This study looks at why some people struggle to lose weight and others find it hard to gain weight. Researchers will measure how the body uses energy after fasting and after a special meal to understand different ways our bodies handle calories. This could lead to better weight management plans.
Germany - RecruitingPHASE3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
This study is testing a new medication called Eloralintide for people with knee osteoarthritis pain who are also overweight or obese. It's a large study aiming to see how well and safely the medication works to help with pain.
United States · Argentina · Belgium - Recruiting
Evaluation of the Care Provided to Patients Who Underwent Bariatric Surgery and Were Lost to Follow-up 5 Years After Surgery
This study looks at why some people who had weight-loss surgery stopped attending their follow-up appointments after five years. It aims to understand their health and experiences to improve care for future patients.
France - RecruitingPHASE1, PHASE2
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
This study looks at a new drug, AZD9550, alone or with another drug, AZD6234, for people who are overweight or living with obesity, with or without Type 2 diabetes. We want to see if it's safe and how it works in the body.
Austria · Canada · Germany - Not yet recruitingNA
Financial Incentives and Weight Loss in Failed Bariatric Surgery
This study looks at whether financial rewards can help people who have regained weight after weight-loss surgery. It explores if a reward system encourages people to achieve and maintain their weight loss goals, and if it's a good way for the health service to help in the future.
France - Recruiting
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
This study looks at blood cells and other substances in people with obesity, diabetes, and fatty liver disease. Researchers want to understand how these differ in people with and without these conditions to learn more about how they develop.
Germany - RecruitingNA
Monitoring the Weight Evolution Using a Connected Scale
This study is looking at a new way to help people who have had weight-loss surgery. It uses smart scales at home to monitor your weight, aiming to improve long-term support and prevent weight regain after your operation.
France - Recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - Active not recruitingPHASE3
Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
This study is looking into a new medication called maridebart cafraglutide. It's for adults with type 2 diabetes who are overweight or have obesity. The main goal is to see if this new medicine helps with weight loss more than a dummy treatment.
United States · Argentina · Bulgaria - Not yet recruitingNA
Weight Reduction With the Low-Insulin-Method - Self Monitoring of Breath Acetone
This study looks at whether an app-based healthy living programme, with or without breath testing to track fat burning, helps adults who are overweight lose weight. The aim is to see if knowing about your body's fat-burning state makes a difference.
Germany - Recruiting
Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes
This study looks at how weight-loss surgery (bariatric surgery), specifically sleeve gastrectomy, affects bone health in people with Type 2 diabetes. We want to see if this surgery makes bones stronger or weaker and compare them to people without diabetes or obesity.
Canada - Not yet recruitingNA
Role of the Environment in Pediatric Obesity
This study looks at how chemicals we find everyday, like those in plastics or used in farming, might be linked to childhood obesity. Researchers are checking blood, urine, and hair samples from children aged 6 to 15, both with and without obesity, to understand environmental effects.
France - RecruitingNA
Exercise Training on Brain Insulin Responsiveness
This study looks at how different types of exercise affect brain's response to insulin in people with and without obesity. Researchers compare moderate exercise, intense interval exercise, and no exercise to see which might be best for brain health. It's about understanding how exercise impacts brain signals related to insulin.
Germany