Acute lymphoblastic leukaemia research hub
5 indexed studies · 4 currently recruiting
- authorisedTherapeutic exploratory (Phase II)
Multicenter, open label, phase II clinical trial of inotuzumab ozogamicin as prophylaxis for relapse in patients with high-risk acute B-cell precursor acute lymphoblastic leukaemia after allogeneic stem cell haemotopoietic transplantation
This study looks at a targeted medicine called inotuzumab ozogamicin (Besponsa). It is for adults with a type of blood cancer called acute lymphoblastic leukaemia who have had a stem cell transplant. Researchers want to see if this treatment can safely stop the leukaemia from returning.
Spain - recruitingPhase IV
Goldilocks - determining if personalised drug monitoring of fludarabine in children and young adults with acute lymphoblastic leukaemia who are undergoing CAR-T therapy is feasible and can improve outcome whilst minimising toxicity
This study called 'Goldilocks' looks at how to give the right amount of a medicine called fludarabine to children and young adults with blood cancer (leukaemia) having CAR T-cell therapy. The goal is to make the treatment work better and have fewer side effects.
United Kingdom · England - recruitingPHASE2, PHASE3
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
This study looks at a new way to treat children and teenagers with a type of blood cancer called Acute Lymphoblastic Leukaemia (ALL). It compares standard treatment with a new approach using chemotherapy instead of radiation, aiming to reduce long-term side effects.
Argentina · Australia · Austria - recruitingPHASE1, PHASE2
Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
This study is looking into a new drug, AZD3632, for certain blood cancers like leukaemia and myelodysplastic syndromes. It aims to check its safety, how well it works, and how the body handles it, both on its own and with another medicine.
United States · Australia · Canada - recruitingPHASE2
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
This study looks at restoring healthy gut bacteria in people with blood cancers before a stem cell transplant. We're testing special capsules (IMT) against a dummy capsule to see if they improve gut health and reduce common problems like infections after transplant.
United Kingdom