Acute Myeloid Leukemia (AML) research hub
9 indexed studies · 1 currently recruiting
- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Safety of TEG001 in patients with r/r AML/high-risk MDS or r/r MM
This early-stage study is testing a new treatment called TEG001. It's for adults with certain blood cancers like acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS), or multiple myeloma (MM) that have come back or are high-risk. The main goal is to see if TEG001 is safe for people to use.
Netherlands - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2, Open-label Study Evaluating the Efficacy, Safety, and Pharmacokinetics (PK) of Luveltamab Tazevibulin (STRO-002) in Infants and Children < 12 years of age with CBFA2T3::GLIS2 Acute Myeloid Leukemia (AML)
This study is testing a new medicine, luveltamab tazevibulin, for babies and children under 12 with a specific type of blood cancer called CBFA2T3::GLIS2 acute myeloid leukaemia (AML). Researchers want to see if it helps these children get better, if it's safe, and how it works in their bodies.
Spain · Denmark · Netherlands - ongoing, recruitingTherapeutic exploratory (Phase II)
Phase II study on Venetoclax (VEN) plus Decitabine (DEC) (VEN-DEC) for elderly (≥60 <75years) patients with newly diagnosed Acute Myeloid Leukemia (AML) elegible for allogeneic Stem Cell Transplantation (allo-SCT)
This study looks at a new treatment called Venetoclax plus Decitabine for older patients (60-74 years) with a type of blood cancer called Acute Myeloid Leukemia (AML). It aims to see if this treatment helps them get a stem cell transplant, which can be a cure for AML.
Italy - recruitingPHASE1
A Study to Investigate APL-4098 Alone and in Combination in Adults With AML or MDS
This study is testing a new drug, APL-4098, alone and with other medicines, for adults with certain types of blood cancers like Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS). Doctors want to see if it's safe, how well it's tolerated, and if it helps.
Australia · United Kingdom - authorisedTherapeutic exploratory (Phase II)
Prospective Phase II study on Safety and Efficacy of Fludarabine plus Treosulfan (14g) (FT14) conditioning regimen for allogeneic Stem Cell Transplantation (allo-SCT) in Acute Myeloid Leukemia (AML) patients (≥40 <65years)
This study is looking at a new way to prepare people with acute myeloid leukaemia (AML) for a stem cell transplant. It's testing a combination of medicines (Fludarabine and Treosulfan) to see if it's safe and effective for adults aged 40 to 65.
Italy - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1 Study of PRT2527 as Monotherapy and in Combination with Zanubrutinib or Venetoclax in Participants with Relapsed/Refractory Hematologic Malignancies
Germany · Poland · Italy - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A first-in-human, Phase 1, Dose Escalation Study of SGR-2921 as Monotherapy in subjects with relapsed/refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Spain · France - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase I / II, open label, dose escalation part (phase I) followed by non-comparative expansion part (phase II), multi-centre study, evaluating safety, pharmacokinetics and efficacy of S65487, a Bcl2 inhibitor combined with azacitidine in adult patients with previously untreated acute myeloid leukemia not eligible for intensive treatment
France · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase 1 Study of UniCAR02-T-CD123 in Patients With Selected CD123 Positive Hematologic Malignancies
Germany · Netherlands