immune hyperactivation in COVID-19 patients and/or research hub
17 indexed studies · 10 currently recruiting
- authorisedPhase I and Phase II (Integrated)- First administration to humans
efficacy and safety of the use of regulatory T cells in immune hyperactivation in patients with COVID-19 and/or acute respiratory distress syndrome
This study is looking at a new treatment involving special immune cells for people very sick with COVID-19 or a severe lung problem called ARDS. It aims to see if this treatment is safe and helps calm down an overactive immune system, which can make these illnesses worse.
Spain - active not recruitingNA
Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway
This study looks at a new care plan called TheraPPP for people in intensive care with serious breathing problems. It aims to make sure everyone gets the best available treatments consistently, helping more patients recover from conditions like ARDS.
Canada - recruiting
EIT Assessment of Overdistension in ARDS Patients in Prone Position
This study looks at how to best set breathing machines for patients with a severe lung condition called ARDS. We use a special scanning belt (EIT) to help doctors find the right balance between opening up parts of the lung and preventing damage when patients are on their front.
France - recruitingNA
Fluid Responsiveness Prediction During Prone Position
This study aims to find the best way to tell if critically ill patients with severe breathing problems, who are lying on their stomachs, would benefit from extra fluids. We're testing four different methods to see which one works best to guide treatment.
France - recruitingPHASE2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
This study is testing a new medicine, Rhu-pGSN, for people with severe breathing problems (ARDS) caused by infections. It will compare the new medicine to a dummy treatment (placebo) to see if it's safe and helps people recover better.
United States · Belgium · Bulgaria - recruitingPHASE3
"Continuous Positive Airway Pressure on Venovenous extracorporeaL Membrane Oxygenation for Acute respIratory Distress syndrOme"
This study called CALMDOWN looks at a new way to help very sick people with severe lung problems (ARDS) who are on a special breathing machine (ECMO). It compares two different breathing settings on the machine to see which one works better to help them recover faster.
France - active not recruiting
ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
This study looks at how well children recover after needing a special life support machine (ECMO) for serious breathing problems (ARDS). It also compares how different ways of starting ECMO affect children's health, learning, and quality of life.
United States · Australia · Canada - recruitingNA
Extended Prone Positioning for Intubated ARDS
This study is looking at whether keeping intensive care patients with severe breathing problems (ARDS) in a 'tummy-down' position for longer periods (40 hours) helps them recover better than shorter periods (16 hours). We want to see if longer periods can save more lives.
France - authorisedTherapeutic confirmatory (Phase III)
APROTININ TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME: A MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE III TRIAL
This study is looking into a treatment called aprotonin for a serious lung condition called Acute Respiratory Distress Syndrome (ARDS). It compares aprotonin to a dummy treatment to see if it helps patients breathe better without a ventilator.
Spain - recruitingNA
Inflammation During ECMO Therapy and ECMO Weaning
This study looks at the best way to take patients off life support called ECMO and a breathing machine (ventilator) when they have severe lung problems. We're comparing two ways: taking them off the ventilator first, or off ECMO first, to see which causes less inflammation and helps lungs heal better.
Germany - recruitingNA
Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)
This study looks at treating severe lung failure (ARDS) with a special life support machine called ECMO. Doctors want to see if starting ECMO early works better than trying other treatments first.
Germany - enrolling by invitation
The Medical Management in Patients Exposed to Weapons of Mass Destruction
This study looks back at how medical teams have responded to major incidents involving dangerous substances over the past 50 years, and will continue to observe future events. It aims to understand how injured people were cared for from the scene of the incident to the hospital.
United States · Canada · Czechia - active not recruitingNA
Influence of NEP Inhibition on Vascular Leak and Inflammation (NEPi-INFLAMMATION)
This study looks at a new way to treat Acute Respiratory Distress Syndrome (ARDS), a severe lung condition. We're testing a drug, Racecadotril, on healthy volunteers. It may help stop fluid leaking into the lungs, a major problem in ARDS, by boosting a natural substance called CNP.
United Kingdom - active not recruitingPHASE1, PHASE2
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)
This study, REALIST, investigates a new treatment for Acute Respiratory Distress Syndrome (ARDS), a severe lung condition where fluid builds up, often affecting critically ill patients. It tests if special cells from umbilical cord blood can help improve lung function and safety compared to a dummy treatment.
United Kingdom - recruitingPHASE2, PHASE3
Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
This study looks at how different types of ongoing sedation affect breathing and lung health in seriously ill patients. We're comparing standard IV sedation with inhaled sedation, often used in surgery, to see which helps patients on breathing machines breathe better and protect their lungs.
United Kingdom - recruiting
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
This study looks at why some critically ill patients who need life support (ECMO) stay weak after leaving intensive care. We want to understand this weakness and how it affects their daily lives and well-being after severe heart and lung problems.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2, proof-of-concept, randomized, double-blinded, placebo-controlled, multicenter study to assess efficacy and safety of reparixin as add-on therapy to standard of care in adult patients with Acute Respiratory Distress Syndrome (RESPIRATIO)
This study is testing a new tablet medicine called reparixin for adults with serious lung problems (Acute Respiratory Distress Syndrome or ARDS). We want to see if it helps improve breathing when given with usual care, and if it's safe.
Italy · Germany