- active not recruitingNA
RNASARC - Molecular Screening Program of Soft Tissue Sarcomas With Complex Genomic Profile to Detect NTRK1/2/3, ROS1 or ALK Gene Fusions.
This study looks for specific gene changes (NTRK, ROS1, ALK fusions) in soft tissue sarcomas. We check tumour samples for these changes using special tests. Finding these changes helps us guide patients to suitable treatments, potentially including a drug called entrectinib.
France - active not recruitingPHASE1
Phase 1 Study of RP-6306 With Carboplatin and Paclitaxel in TP53 Ovarian and Uterine Cancer
This study looks at a new drug, RP-6306, combined with standard medicines (carboplatin and paclitaxel) for advanced ovarian or womb (uterine) cancer. We want to find the safest dose and see how well it works, especially for cancers with a specific gene change called TP53.
Canada - active not recruitingNA
Phase II RCT of an Internet-adaptation of Managing Cancer and Living Meaningfully (iCALM)
This study looks at 'iCALM', an online course to help people with advanced cancer manage their feelings and wellbeing. It's based on a successful in-person programme and aims to see if an online version is helpful and easy to use for those who might be feeling down or anxious.
Canada - recruiting
Molecular Tumor Board at the Center for Personalized Medicine Tübingen
This study looks at how a 'Molecular Tumour Board' helps doctors make treatment choices for people with advanced cancer. They check patient details, see how well treatments work, and how patients feel, aiming to improve future care.
Germany - active not recruitingPHASE1
POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC
This study combines two drugs, tepotinib and pembrolizumab, for advanced non-small cell lung cancer. It explores if tepotinib can make immunotherapy like pembrolizumab more effective, especially for cancers that usually don't respond well to such treatments.
United Kingdom - active not recruitingPHASE1
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
This study is testing a new combination of two drugs, ASTX660 and pembrolizumab, for people with advanced cancers like cervical cancer and a type of breast cancer. It's a first step to see if this new approach can boost the body's own immune system to fight cancer.
United Kingdom - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - active not recruitingPHASE2
A Study of Avelumab in Penile Cancer Who Are Unfit for or Have Progressed After Platinum-Based Chemotherapy
This study looks at a new drug called avelumab for men with advanced penile cancer. It's for those who can't have standard chemotherapy or for whom it has stopped working. We want to see if avelumab can help shrink their tumours.
Canada - recruitingPHASE3
A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)
This study offers continued access to a cancer treatment for patients who are already benefiting from it in previous trials. It aims to check the long-term safety and effectiveness of the medication for people with advanced or metastatic cancer.
United States · Australia · Belgium - authorisedTherapeutic exploratory (Phase II)
The Swedish Nationwide Clinical Trial to Facilitate Patient Access to Targeted Cancer Treatment based on Biomarker Profiling (FOCU.SE)
This study, called FOCU.SE, is looking at new ways to treat advanced cancer in Sweden. It aims to match patients with specific treatments based on their cancer's unique features, hoping to find more effective ways to fight the disease.
Sweden - recruitingNA
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy in Patients With Cancer-Related Celiac Pain
This study looks at a new, faster way to give radiation treatment for pain caused by cancer in the tummy area. It aims to see if treatment planning and delivery can happen in one visit, instead of over many days, using existing scans and special adjustments on the day of treatment.
Canada - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - active not recruitingPHASE2
A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
This study looks at new treatments (ramucirumab or merestinib) combined with standard chemotherapy for people with advanced biliary tract cancer. It aims to see how well these new drug combinations work and if they are safe.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
A Safety, Pharmacokinetic and Clinical Activity Study of NUC-7738 in Patients With Advanced Solid Tumours and Lymphoma
This study is testing a new drug, NUC-7738, for people with advanced cancers like solid tumours and lymphoma. It aims to see how safe the drug is, how it works in the body, and if it helps treat these cancers, sometimes combined with pembrolizumab.
United Kingdom - recruitingPHASE1, PHASE2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
This study is testing a new drug, ART0380, for people with advanced cancer. It aims to find the safest dose, understand side effects, and see how well it works, both alone and with other treatments like gemcitabine or irinotecan.
United States · France · Spain - active not recruitingPHASE1, PHASE2
Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors
This study is testing different combinations of new drugs, including EOS-448, with or without standard treatments for advanced cancers like lung and head & neck cancer, and melanoma. Researchers want to see if these combinations are safe and effective.
United States · Belgium · France - active not recruitingPHASE1
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
This study is testing a new cancer medicine, botensilimab, sometimes with another drug, balstilimab. It's for people with advanced cancers that haven't responded to other treatments. Doctors want to see if it's safe, how it works, and find the best dose.
United States · United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to determine how nanatinostat is absorbed, modified, and removed from the body and the amount of nanatinostat that becomes available to the body in patients with cancers that is very large or has spread to other parts of the body
This study is looking at a new drug called nanatinostat for people with advanced cancer. It aims to understand how the body uses and gets rid of the drug, and how much of it reaches the bloodstream. This will help doctors find the right dose for future studies.
Spain - recruiting
Routine Evaluation of People Living With Cancer
This study looks at how incurable cancer affects people's bodies and daily lives. We want to understand common problems like weight loss, tiredness, and how cancer affects their bodies. This will help doctors plan better care and future treatments for people like you.
United Kingdom