Myeloproliferative Disorders research hub
7 indexed studies · 5 currently recruiting
- active not recruitingPHASE3
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
This study looks at a new drug, Luspatercept, for people with myelofibrosis and anaemia who need regular blood transfusions and are already taking a JAK2 inhibitor. We want to see if it helps reduce the need for transfusions.
United States · Argentina · Australia - active not recruitingPHASE1, PHASE2
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
This study looks at a new drug, INCB000928, by itself or with ruxolitinib, for people with myelofibrosis who have anaemia (low red blood cells) and need blood transfusions, or have anaemia symptoms. It aims to find a safe and effective dose.
United States · Canada · France - recruitingPHASE3
A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
This study compares Elritercept with Epoetin Alfa for adults with a certain type of Myelodysplastic Syndrome (MDS) and anaemia. It checks if Elritercept reduces the need for blood transfusions and improves tiredness, while also looking at safety.
United States · Argentina · Australia - recruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
United States · Argentina · Australia - recruitingNA
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
This study looks at treating diabetic foot ulcers with a procedure called angioplasty. Researchers want to know if having this treatment quickly makes a bigger difference to healing than having it later. It's about finding the best timing for care.
Germany - recruiting
Research Platform Myelofibrosis and Anemia
This study in Germany looks at how people with myelofibrosis and anaemia are treated in real life. It collects information about their health, treatments, and how they feel over time to understand common treatment patterns and changes in their care.
Germany - recruitingPHASE2
A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia
This study looks at a new medicine called luspatercept for people with a type of anaemia called alpha-thalassaemia. It aims to see if the medicine is safe and helps reduce the need for blood transfusions.
Canada · China · Greece