Frailty research hub

Visual Frailty in Ageing

This study looks at 'visual frailty' in older people with a common eye condition called AMD. Researchers want to understand and measure how vision problems, general health, and mental well-being are linked, to help improve care for ageing eyes.

The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

This study looks at whether high doses of Vitamin B6 can help reduce feelings of anxiety and depression. Researchers want to see if it changes brain activity and improves symptoms in people aged 18-41.

Effectiveness of CAT-GSH for Returning Patients

This study looks at two types of guided self-help therapy for people who have had anxiety or low mood before and are returning to NHS Talking Therapies. It compares CAT-GSH with CBT-GSH to see which works best and is preferred for those coming back for more support.

Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI

This study looks at how anxiety and depression affect older people with a serious leg condition (CLTI) and their surgery outcomes. It explores how doctors can work with patients to make important healthcare decisions.

CBT and the Neural Circuits of Anxiety

This study looks at how a talking therapy called CBT changes the brain in people with anxiety. It aims to understand why CBT works, hoping to make treatments even better and more personal for anxiety in the future.

Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders

TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety

This study is looking at a mobile phone app called TrueBlue. It aims to see if the app can safely and helpfully monitor feelings of depression and anxiety in pregnant women and new mothers in Nottinghamshire. We want to find out how easy it is to use and if it works well.

Virtual Reality in Elective Caesarean Births Study (VREC)

This study looks at whether watching a special virtual reality film can help reduce anxiety for women having an planned C-section at Royal United Hospital. It compares this film to the usual information given to see if it makes a difference.

Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.

This study looks at whether a special nutritional drink, 'Think Tank', can help middle-aged women aged 40-60 think more clearly after stressful experiences. Researchers will compare it to a dummy drink to see if it improves memory, attention, and overall well-being.

Fibre and Mental Wellbeing Feasibility Trial

This study looks at whether eating an extra 10 grams of fibre daily for two weeks can improve how young adults aged 18-40 feel mentally. It focuses on sleep, anxiety, and stress to see if diet changes can boost well-being.

The sedative effects and local tolerability of nasal administration of remimazolam using a Soft Mist Nasal Administration Device

This study is looking at a new way to give medicine called Byfavo through a nose spray. It aims to see how well it helps people feel calm and sleepy when they're feeling stressed or anxious, and if it's comfortable to use.

A Randomized Open-Label, Parallel-Group, Phase 2, 2-Arm Study to Investigate the Pharmacokinetic Profiles of Midazolam Subcutaneous Injection Compared with Midazolam Intravenous Injection in Adult Male and Female Terminally Ill Patients

This study compares two ways of giving a medicine called midazolam to people with difficult symptoms at the end of their lives. It looks at how the body handles the medicine when given as an injection under the skin versus directly into a vein.