- recruiting
REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure
This study looks at people who need a new heart valve after their first TAVI valve wears out. We're studying a keyhole procedure called 'Redo TAVI' (putting a new valve inside the old one), along with other treatments, to find the best ways to help patients.
Denmark · Finland · France - recruitingNA
Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
This study compares two ways to look after people who develop a new heart rhythm problem called Left Bundle Branch Block (LBBB) after a TAVI heart procedure. It aims to see which method best prevents fainting, hospital stays, or worse.
Canada · France - active not recruitingNA
Prolonged Continuous ECG Monitoring Prior to Transcatheter Aortic Valve Implantation
This study looks at heart rhythm problems in people with a heart valve condition called aortic stenosis before they have a TAVI procedure. By checking heart rhythms for a week beforehand, doctors hope to better manage these issues, potentially leading to smoother recovery and shorter hospital stays.
Canada - recruiting
Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis
This study looks at how well two common heart tests, FFR and iFR, work in people with a severe heart valve problem called aortic stenosis. It compares their results to another type of heart scan (PET) to see if these tests accurately show blockages in the heart's arteries.
Germany - recruiting
The Leipzig TAVI Registry
This study looks at people in Leipzig, Germany, who had a special heart procedure called TAVI for a condition called aortic valve stenosis. Researchers are following them for up to 10 years to see how well their new heart valve works over time.
Germany - active not recruiting
ACURATE neo2™ Post Market Clinical Follow up Study
This study looks at how well a new tiny heart valve, called ACURATE neo2, works in real-world patients. Doctors are checking its safety and performance when treating a serious heart condition called aortic valve stenosis.
Denmark · Germany · Italy - recruiting
Multi Modal Cardiac Imaging Prior Transcatheter Aortic Valve Implantation
This study compares different ways to get clear pictures of the heart's main artery before a procedure called TAVI. TAVI helps people with a heart valve problem called aortic stenosis who can't have or are at high risk for open-heart surgery.
Germany - recruitingPHASE2
Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort
This study looks at how inflammation in the heart muscle after a keyhole heart valve replacement (TAVI) might affect the heart's electrical system. We're using a special scan to see if we can predict who might need a pacemaker afterwards, aiming to reduce unnecessary pacemaker fittings.
France - recruiting
MYVAL Transcatheter Heart Valve System - Prospective German Multicenter Registry
This study in Germany is looking at how well a new heart valve, called the Myval Transcatheter Heart Valve, works. It's for people with a heart condition called aortic valve stenosis. They want to see how effective and long-lasting it is in real-world patients.
Germany - recruitingNA
LANDMARK Trial: a Randomised Controlled Trial of Myval THV
This study, called the LANDMARK Trial, is looking into how safe and effective a new heart valve called Myval THV is. It's compared to existing valves for people with a common heart condition called aortic valve stenosis. The goal is to see if it works just as well.
Belarus · Brazil · Croatia - not yet recruiting
TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease
This study looks at a new way to treat problems with the heart's aortic valve, called TAVI, using the Trilogy Heart Valve System. It helps doctors understand how well this treatment works for people with a narrowed or leaky aortic valve. It's for patients aged 18 and over.
Germany - enrolling by invitationNA
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
This study is looking at a new heart valve replacement called Navitor TAVI. It wants to see if it's safe and works well for people with a common heart problem called severe aortic stenosis, which narrows a main heart valve. It's for adults at different surgical risks.
United States · Australia · Belgium - recruitingNA
A Study to Obtain Imaging Data in 40 Patients Having Transcatheter Aortic Valve Implantation (TAVI)
This study looks at CT and heart echo scans done before a TAVI heart valve procedure. We want to see if these scans can predict how well the new valve will work later. Patients will have an extra CT scan after their procedure.
United Kingdom - recruitingNA
Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
This study compares two types of replacement heart valves (Allegra and Sapien) for people who have already had a heart valve operation and their artificial valve is wearing out. It aims to see which valve works better for this specific situation.
Italy · Spain · United Kingdom - active not recruiting
SAPIEN 3 Ultra System PMCF
This study looks at how a new heart valve (SAPIEN 3 Ultra System) works in people with a common heart problem called aortic stenosis. It's a follow-up study to see how well the valve performs after it's been used in patients in the real world.
Austria · Canada · Denmark - active not recruitingNA
Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Low to Intermediate Risk of Mortality
This study compares two ways to fix a narrowed heart valve: TAVI (a keyhole procedure) and SAVR (open-heart surgery). It's for people with severe narrowing who are considered low to medium risk for surgery. The aim is to see if TAVI is just as safe and effective as SAVR.
Germany - recruiting
Effect of Fetal Aortic Valvuloplasty on Outcomes
This study looks at a procedure called fetal aortic balloon dilation for babies whose hearts aren't developing properly before birth. We want to see if this treatment helps prevent a severe heart condition called HLHS and improves their health outcomes while checking for any side effects.
United States · Austria · Canada - recruitingPHASE4
Angiotensin Receptor Blockers in Aortic Stenosis
This study is looking at whether a common type of blood pressure medicine, called ARBs, can help slow down a heart valve problem called aortic stenosis. We want to see if ARBs can protect the heart and stop the condition from getting worse in people with a mild to moderate form of the disease.
Canada · Denmark - active not recruitingNA
Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS
This study looks at treating severe aortic valve narrowing earlier in people who don't have symptoms. Researchers are using MRI scans to find early signs of heart strain. They want to see if earlier surgery improves outcomes compared to waiting.
United Kingdom - active not recruitingNA
Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
This study looks at a new way to treat heart failure caused by a narrowed heart valve. It compares a procedure called TAVR, which replaces the valve without open surgery, to standard heart failure treatments. The goal is to see if TAVR can help improve heart health.
United States · Canada · Netherlands - recruiting
Hamburg AoRtic Valve cOhoRt
This study looks at the best ways to treat a heart condition called aortic valve disease. Doctors want to understand which treatments work best for different people, considering their health and how they might recover. They are comparing treatments like surgery and a less invasive procedure.
Germany - recruiting
The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI)
This study looks at how different types of replacement heart valves wear out over time. We're also checking if tiny blood clots on these valves, which you wouldn't feel, affect how quickly they start to show signs of damage after 5 years.
Denmark · Netherlands · United Kingdom - recruiting
Avalus European Registry - an Observational Study to Evaluate Safety and Efficacy in a Real World Population
This study looks at how well a new heart valve called Avalus works in real-world patients needing surgery for a faulty aortic valve. Doctors are checking its safety and performance after it's been implanted.
Belgium · Denmark · Finland - recruitingNA
TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics
This study looks at how the position of a new heart valve after a TAVR procedure affects blood flow and important arteries. It also checks if new scanning methods can give us the same information as current ones, helping doctors fine-tune future treatments.
Germany - recruitingNA
Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR
This study is looking at the best way to check how well a new heart valve is working after a special procedure called ViV-TAVR. Doctors usually use ultrasound, but this study compares ultrasound with another method using a small tube (catheter) to see which is more accurate. This helps ensure patients get the best possible care.
United States · Canada - recruiting
Hydra Registry - UK
This study looks at a new heart valve called Hydra for people with a serious heart condition called aortic stenosis. We want to see how well it works and if it's safe for up to a year after it's put in, and also test a new heart monitoring device.
United Kingdom - active not recruitingNA
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) for people with a common heart condition called aortic stenosis. It focuses on patients with smaller heart valve openings to see which valve works best.
United States · Canada · Denmark - recruitingNA
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
This study compares two types of heart-lung machines used in heart surgery: the standard one and a newer, smaller version. It aims to see if the smaller machine leads to fewer serious problems after surgery for conditions like coronary artery disease and aortic valve issues.
Canada · Germany · Greece - active not recruiting
Inspiris Resilia Durability Registry
This study looks at how well a new heart valve, called INSPIRIS RESILIA, works for people under 60 who need surgery for a narrowed aortic valve. We follow patients for five years to see if it's safe and effective in real life.
Austria · Belgium · Canada - recruitingNA
Remote Cardiovascular Monitoring in Post-TAVI Patients
This study looks at whether remote monitoring after a heart valve procedure (TAVI) can help patients go home sooner and avoid readmission. It compares a special remote monitoring program with standard care for people who have had TAVI.
United Kingdom