Aortic Valve Calcification research hub
13 indexed studies · 7 currently recruiting
- authorisedTherapeutic confirmatory (Phase III)
Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.
This study looks at whether a widely used medicine called colchicine can slow down the hardening of the heart's aortic valve. Researchers will compare people taking colchicine with those taking a dummy pill, to see if it helps keep the valve working better for longer. It's a big study to find out if this treatment could be useful.
Netherlands - active not recruitingNA
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) for people with a common heart condition called aortic stenosis. It focuses on patients with smaller heart valve openings to see which valve works best.
United States · Canada · Denmark - active not recruitingNA
Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS
This study looks at treating severe aortic valve narrowing earlier in people who don't have symptoms. Researchers are using MRI scans to find early signs of heart strain. They want to see if earlier surgery improves outcomes compared to waiting.
United Kingdom - recruitingNA
Remote Cardiovascular Monitoring in Post-TAVI Patients
This study looks at whether remote monitoring after a heart valve procedure (TAVI) can help patients go home sooner and avoid readmission. It compares a special remote monitoring program with standard care for people who have had TAVI.
United Kingdom - recruiting
Hydra Registry - UK
This study looks at a new heart valve called Hydra for people with a serious heart condition called aortic stenosis. We want to see how well it works and if it's safe for up to a year after it's put in, and also test a new heart monitoring device.
United Kingdom - active not recruiting
SAPIEN 3 Ultra System PMCF
This study looks at how a new heart valve (SAPIEN 3 Ultra System) works in people with a common heart problem called aortic stenosis. It's a follow-up study to see how well the valve performs after it's been used in patients in the real world.
Austria · Canada · Denmark - recruiting
The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI)
This study looks at how different types of replacement heart valves wear out over time. We're also checking if tiny blood clots on these valves, which you wouldn't feel, affect how quickly they start to show signs of damage after 5 years.
Denmark · Netherlands · United Kingdom - recruitingNA
Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
This study compares two types of replacement heart valves (Allegra and Sapien) for people who have already had a heart valve operation and their artificial valve is wearing out. It aims to see which valve works better for this specific situation.
Spain · United Kingdom - recruitingNA
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
This study compares two types of heart-lung machines used in heart surgery: the standard one and a newer, smaller version. It aims to see if the smaller machine leads to fewer serious problems after surgery for conditions like coronary artery disease and aortic valve issues.
Canada · Germany · Greece - recruitingNA
A Study to Obtain Imaging Data in 40 Patients Having Transcatheter Aortic Valve Implantation (TAVI)
This study looks at CT and heart echo scans done before a TAVI heart valve procedure. We want to see if these scans can predict how well the new valve will work later. Patients will have an extra CT scan after their procedure.
United Kingdom - active not recruiting
ACURATE neo2™ Post Market Clinical Follow up Study
This study looks at how well a new tiny heart valve, called ACURATE neo2, works in real-world patients. Doctors are checking its safety and performance when treating a serious heart condition called aortic valve stenosis.
Denmark · Germany · Italy - recruiting
REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure
This study looks at people who need a new heart valve after their first TAVI valve wears out. We're studying a keyhole procedure called 'Redo TAVI' (putting a new valve inside the old one), along with other treatments, to find the best ways to help patients.
Denmark · Finland · France - active not recruiting
Inspiris Resilia Durability Registry
This study looks at how well a new heart valve, called INSPIRIS RESILIA, works for people under 60 who need surgery for a narrowed aortic valve. We follow patients for five years to see if it's safe and effective in real life.
Austria · Belgium · Canada