- not yet recruitingPHASE4
Study of the Effects of Atomoxetine on Motivation
This study looks at how a medicine called atomoxetine affects motivation in people with apathy, which is when you feel very low on drive and energy. We want to see if increasing a brain chemical called noradrenaline can help people feel more motivated and focus better.
United Kingdom - recruitingPHASE2
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
This study is looking at a new way to help people with Alzheimer's disease who feel unmotivated or apathetic. It combines a brain stimulation method with a commonly used medicine to see if it can improve these feelings.
Canada - recruitingPHASE1, PHASE2
Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy
This study is testing a new medicine, IRL757, for people with Parkinson's disease who also have apathy (a lack of interest or drive). Researchers want to see if the medicine is safe, well-tolerated, and if it helps with Parkinson's symptoms. Some people will get the real medicine, others a dummy pill.
Bulgaria · Germany · Poland - recruiting
Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders
This study looks at how a special app using old memories might help people with early memory problems feel better. It focuses on improving mood, motivation, and sleep by using digital memory prompts and seeing if simple reminders encourage regular use.
France - recruitingPHASE3
In Vivo Involvement of the Cholinergic and Dopaminergic Systems in the Pathophysiology of Apathy.
This study looks at how brain chemicals like dopamine and acetylcholine affect 'apathy' after a stroke. Researchers use special brain scans (PET and MRI) to understand why some people feel a lack of motivation, hoping to find better ways to help them.
France