- ongoing, recruitingTherapeutic exploratory (Phase II)
J1A-MC-KDAF: A Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, peresolimab, for adults with moderate to severe rheumatoid arthritis. It aims to see if the medicine can reduce arthritis symptoms, like joint pain and swelling, better than a dummy treatment.
Hungary · Spain · Italy - recruitingNA
RT-CGM in Young Adults at Risk of DKA
This study looks at how a special device called real-time continuous glucose monitoring (RT-CGM) helps young adults, aged 18-25, manage their type 1 diabetes. We want to see if it improves blood sugar control and reduces hospital visits for high blood sugar.
United Kingdom - recruitingPHASE2
A Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A Nephropathy
This study looks at a new drug, Sparsentan, for people with kidney disease called IgA Nephropathy. It aims to see if the drug is safe and helpful in protecting the kidneys, both for newly diagnosed patients and those who have had a kidney transplant.
United Kingdom - active not recruiting
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study looks at how memory and thinking skills (cognition) change after hip or knee replacement surgery. Researchers want to understand these changes better, identify who might be at higher risk, and find ways to improve recovery. It focuses on changes that might last longer than a few months.
Canada - recruiting
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
This study looks back at records of over 1,200 patients in France who had a rare blood disorder called iTTP. It aims to understand how things like heart problems and specific treatments affect their long-term health and survival. It hopes to improve care for people with iTTP.
France - recruiting
Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders
This study looks into why some people have long-term problems with constipation or emptying their bowels. Researchers are examining tiny nerves in bowel tissue samples and blood to understand what might be causing these issues, hoping to find new ways to treat them effectively.
Germany - recruitingNA
MUSic Therapy In Complex Specialist Neurorehabilitation
This study looks at whether adding music therapy to standard rehabilitation helps people recover better after serious brain or spinal cord injuries. It compares music therapy to usual care to see if it improves daily activities and well-being in patients aged 16-80.
United Kingdom - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - recruiting
Natural History of Type 1 Interferonopathies: Insights From a European Cohort
This study looks at rare genetic conditions called Type 1 interferonopathies, which affect the immune system and can cause various health problems. Researchers want to understand how these conditions develop over time in both children and adults to find better ways to diagnose and treat them.
Austria · Belgium · Croatia - recruitingNA
Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases
This study is collecting blood samples from children and adults with rare autoimmune and autoinflammatory diseases, and their families. This collection will help researchers understand these conditions better and find new ways to diagnose and treat them.
France - recruiting
Analysis of TPE Treatments With multiFiltratePRO
This study looks at how well a special filtering machine, called multiFiltratePRO, works for people with autoimmune diseases. It checks how effectively the machine removes harmful substances from the blood, aiming to improve treatments like therapeutic plasma exchange (TPE).
Germany - recruiting
X-linked Moesin Associated Immunodeficiency
This study looks at X-linked Moesin Associated Immunodeficiency (X-MAID), a rare condition affecting the immune system. Researchers are gathering information from patients worldwide to better understand how to diagnose and treat this illness, aiming to create clearer guidelines for doctors.
United States · Australia · Belgium - recruiting
Prospective Study of White Blood Cells
This study looks at white blood cells from healthy volunteers to help create new treatments for serious conditions like autoimmune diseases and organ transplant rejection. By understanding these cells better, scientists hope to develop new medicines that can regulate the body's immune system.
United Kingdom