- completedPhase II
Melatonin In Acute Mania Investigation (MIAMI-uk)
This study tests whether melatonin, a natural sleep hormone, helps treat acute mania in bipolar disorder. Adults aged 18 to 65 take either melatonin or a dummy tablet every night for three weeks to see if better sleep helps calm manic symptoms and prevents hospital stays.
United Kingdom · England - completed
A trial of ‘cognitive remediation therapy’ to improve thinking skills and everyday functioning for people with bipolar disorder
This UK clinical trial is testing a talking and brain-training therapy called cognitive remediation therapy (CRT) for adults with bipolar disorder. Researchers want to find out if CRT can improve everyday thinking skills—like memory and attention—and help people manage work and daily life better than usual NHS care alone.
United Kingdom · England - completed
Online integrated bipolar parenting intervention study
This UK study tests whether a free, confidential online parenting programme helps parents with bipolar disorder. Researchers want to see if the programme boosts parenting confidence, lowers stress, and supports children's behaviour and emotional health. Taking part is entirely done from home using an internet-connected phone, tablet, or computer.
United Kingdom · England - recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of memantine as antimanic and mood-stabilizing medication for adolescents with Bipolar Disorder: a monocentric, randomized, double-blind, placebo-controlled clinical trial.
This study is looking at a medicine called memantine to see if it can help teenagers with bipolar disorder. It's comparing memantine to a dummy pill (placebo) to check if it reduces manic symptoms and helps keep mood stable. The study will last for 52 weeks.
Italy - completed
A trial of a new psychological intervention of cognitive behaviour therapy for young people with distressing mood swings
This UK study tests whether a specialised talking therapy, called Cognitive Behavioural Therapy (CBT), helps young people aged 16 to 25 manage distressing mood swings. Researchers want to find out if early psychological support can improve wellbeing and lower the risk of developing bipolar disorder in the future.
United Kingdom · England - completed
Randomised controlled trial investigating therapy for bipolar inter-episode symptoms
This UK study tests a new talking therapy for people with bipolar disorder. It aims to help those who still deal with low mood or mood swings between major episodes. Participants will either try the new therapy alongside their usual care or continue with their usual care alone.
United Kingdom · England - recruitingPhase III
Assessing the effectiveness of lithium plus quetiapine compared to lithium alone or quetiapine alone for treatment of adults with bipolar disorder
This study looks at how well two common bipolar disorder medications, lithium and quetiapine, work alone or together to prevent mood swings. It wants to find the best long-term treatment to help people stay stable and improve their quality of life.
United Kingdom · England - recruiting
A trial of a patient app and care team interface designed to facilitate shared decision making for people with bipolar disorder
This study is testing a new health app for people with bipolar disorder. It aims to help patients and their doctors work together better on treatment plans, potentially improving care and reducing hospital visits.
United Kingdom · England - recruitingNA
Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
This study helps adults with severe mental illness improve their romantic and social skills. It's a group program called "Better Together" that aims to reduce loneliness and build confidence for healthy relationships, supported by mental health experts.
France - recruiting
Basal Plasma Lithium Levels and Suicidal Events
This study looks at how natural lithium levels in the body might be linked to suicidal thoughts and actions in people with depression. It compares those with and without a history of suicidal events to understand how lithium could help prevent them.
France - recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine
This study is looking into a new medication called KarXT to help people aged 18-65 with Bipolar-I disorder who are having a manic episode. It wants to see if KarXT, when added to current treatments like lithium, valproate, or lamotrigine, is safe and effective.
United States · Argentina · Bulgaria - recruitingNA
Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects
This study looks at a new blood test, EDIT-B®, to help doctors tell the difference between two types of depression: major depression and bipolar disorder. This is important because the treatments are different, and getting the right diagnosis sooner can improve health and prevent serious problems.
France - recruitingNA
Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression
This study looks into a new, gentle way to treat depression and bipolar disorder called transcutaneous auricular vagus nerve stimulation (tVNS). It aims to understand how tVNS works and if it can help people, without surgery. Researchers will compare tVNS to a dummy treatment.
Germany - recruitingNA
Time and Virtual Reality in Schizophrenia and Bipolar Disorder
This study uses virtual reality games to explore how people with schizophrenia and bipolar disorder experience time differently. Researchers hope to better understand these differences, which might help predict who could develop psychosis.
France - active not recruiting
Characterizing MyMood Patterns of Use
This study looks at how people use MyMood, a special online tool for tracking moods, developed at Sunnybrook Health Sciences Centre. We want to see if things like age, sex, or having a mood disorder affect how often and how long people use it. MyMood helps people with conditions like depression and bipolar disorder.
Canada - recruitingNA
Evaluation of Efficiency of One Day Patient/Caregiver Psychoeducation on the Caregiver's Burden
This study looks at a short, one-day course for caregivers of people with bipolar disorder. It aims to see if this course helps reduce the stress and burden caregivers might feel, and if it improves their understanding of the condition.
France - recruitingNA
Skills for Wellness
This study, 'Skills for Wellness', helps young people (9-21) at high risk of severe mental illness like schizophrenia or bipolar disorder. It tests a new talking therapy called maCBT to prevent these conditions by teaching skills to manage early warning signs like anxiety or unusual experiences.
Canada - active not recruitingNA
Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth
This study looks at a new talking therapy called NECT-Y for young people with bipolar disorder or other mental health conditions. It wants to see if this therapy can help reduce self-stigma, which is negative feelings about having a mental health condition.
Canada - recruitingNA
Three-level Model of DBT-informed Care for Youth With and/or at Familial Risk for Bipolar Disorder (DB3)
This study looks at different levels of therapy for young people with, or at risk of, bipolar disorder. It aims to find out if offering different amounts of therapy, from less intense to more intense, can be helpful, depending on individual needs and preferences.
Canada - recruitingNA
Pragmatic Patient-oriented Extension Study of Dialectical Behavior Therapy Booster Sessions for Youth With and/or at Familial Risk for Bipolar Disorder
This study looks at 'booster' sessions for young people with, or at risk of, bipolar disorder who have already had a year of a therapy called DBT. It explores how these extra sessions, tailored to each person, can help them continue to manage their condition.
Canada - recruitingPHASE3
Cannabidiol for Bipolar Depression (CBD-BD)
This study is looking at whether a cannabis-based chemical called cannabidiol (CBD) can help people with bipolar depression. It compares CBD to a dummy pill (placebo) to see if it's safe and effective when added to usual treatments. Both men and women aged 19-70 can take part.
Canada