- active not recruitingPHASE3
A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma
This study compares a new drug (niraparib) with standard treatment (temozolomide) for a type of brain tumour called glioblastoma. We want to see if niraparib can help people live longer. Participants will take medication daily alongside radiotherapy.
United States · Australia · Canada - recruitingNA
FIH Clinical Investigation of Graphene Electrodes for Brain Mapping
This study tests new, very thin brain sensors made from a material called graphene. Doctors want to see if these sensors are safe and work well during brain tumour surgery to help protect important brain functions.
United Kingdom - recruitingPHASE2
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids
This study looks at adding a cannabis-based medicine (Nabiximols) to standard treatment (Temozolomide) for a type of brain tumour called glioblastoma that has come back. It aims to see if this combination works better than standard treatment alone.
United Kingdom - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - active not recruitingNA
Blood-Brain Barrier Disruption Using Transcranial MRI-Guided Focused Ultrasound
This study looks at a new way to treat brain tumours using special ultrasound waves to temporarily open the brain's protective barrier. This might help medicine reach the tumour better. We need to check if it's safe before seeing how well it works.
Canada - recruitingNA
Biofeedback for Hemianopia Vision Rehabilitation
This study looks at a new training method called biofeedback for people who have lost half of their vision (hemianopia) due to brain injury like a stroke. It aims to see if this method helps improve eye movements and vision, and how best to use it.
Canada - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - recruitingNA
Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.
This study looks at how certain proteins, MMP2 and MMP9, behave in adults newly diagnosed with a type of brain tumour called glioblastoma. We want to see if changes in these proteins in blood and tumour samples, along with their activity, can tell us more about the tumour and how it responds to treatment.
France - recruitingPHASE3
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
This study aims to see if a special ultrasound device, Exablate, can help standard cancer medicines work better for people with lung cancer that has spread to the brain. Researchers will compare this new approach to standard care alone.
United States · Canada · South Korea - not yet recruitingPHASE2
The Use of 5-ALA in Paediatric Patients With High Grade Brain Tumours
This study looks at a special dye, 5-ALA, to help surgeons remove brain tumours in children aged 3-18. It aims to see if 5-ALA is safe and helps doctors see the tumour more clearly, to remove as much as possible while protecting healthy brain tissue.
United Kingdom