- recruitingPhase IV
A shorter duration of antibiotic treatment versus a longer duration of antibiotic treatment for patients with a flare-up of their chronic lung condition requiring intravenous antibiotics
This UK trial looks at whether a 7-day course of intravenous (IV) antibiotics works just as well as the standard 14-day course for bronchiectasis flare-ups. Researchers want to see if shorter treatment helps people stay well for longer, reduces side effects, and cuts the risk of antibiotic resistance.
United Kingdom · Scotland - recruitingPhase II
AIR-NET- Testing anti-inflammatories for the treatment of bronchiectasis
The AIR-NET study tests whether three existing medicines can calm lung inflammation in adults with bronchiectasis. Researchers want to find out if repurposing these safe, well-known drugs can help ease daily symptoms, reduce chest damage, and offer better treatment options alongside usual care for people living with this lung condition.
United Kingdom · England · Northern Ireland - completedNot Applicable
A 2x2 factorial randomised open label trial to determine the CLinical and cost-Effectiveness of hypertonic saline (HTS 6%) and carbocisteine for Airway cleaRance versus usual care over 52 weeks in bronchiectasis
This UK clinical trial investigates whether two mucus-clearing treatments—a salty water mist (hypertonic saline) and a capsule called carbocisteine—help people with bronchiectasis. Researchers want to find out if using these treatments on their own or together helps reduce chest infections and improves daily quality of life compared with usual care.
United Kingdom · England · Northern Ireland - recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, parallel-group, Proof-of-Concept (PoC) study to assess the efficacy, safety and tolerability of itepekimab, in participants with non-cystic fibrosis bronchiectasis
This study is testing a new medicine, itepekimab, for people with bronchiectasis. It aims to see if the medicine can reduce flare-ups of their condition and if it's safe to use. Half the people will get the new medicine, and half will get a dummy medicine.
Italy · Czechia · Spain - recruitingPHASE3
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is looking into a new medicine, BI 1291583, for people with bronchiectasis. It aims to see if this medicine can help reduce flare-ups, which are common with the condition. Participants will take a tablet daily and be monitored for up to 1 year and 8 months.
United States · Argentina · Australia - recruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
United Kingdom · England · Northern Ireland - completed
Feasibility and acceptability of using a shared decision making intervention to support patient choice of airway clearance techniques in bronchiectasis physiotherapy consultations in the NHS
This study aims to make it easier for people with bronchiectasis to choose the best airway clearance technique (ACT) with their physiotherapist. It tests a shared decision-making approach to help patients and healthcare providers work together for better treatment choices.
United Kingdom · England - active not recruitingPHASE2
Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine
This study is for adults with bronchiectasis who were in a previous trial with the medicine BI 1291583. It aims to see if this medicine helps long-term and how well people tolerate it. Participants take tablets daily and visit the clinic regularly.
United States · Australia · Belgium - recruiting
Breathlessness Perceptions Within Respiratory Diseases
This study looks at why people with lung conditions feel breathless. We will check how breathing, feelings, and everyday activities affect breathlessness. The goal is to understand breathlessness better to find new ways to help people feel more comfortable and healthy.
United Kingdom - recruitingPHASE1, PHASE2
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis
This study is looking at a new inhaler medicine, CHF6333, for people with bronchiectasis. It checks how safe it is and how the body handles it, in healthy people and those with the condition, both after single and repeated doses.
United Kingdom - authorisedPhase III and phase IV (Integrated)
Randomized, double-blind, parallel-group clinical trial, compared with placebo to evaluate the efficacy and safety of three antibiotic treatment regimens for the eradication of primary P. aeruginosa infection in patients with bronchiectasis
This study is looking for better ways to treat a germ called P. aeruginosa in people with bronchiectasis. It compares different antibiotic treatments to see which ones work best and are safest to get rid of the infection.
Spain - recruiting
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
This study looks at breathing problems during sleep in people with long-term lung conditions like asthma or COPD. Researchers are using a new way to analyse sleep study data to better understand how these conditions affect sleep and breathing.
United Kingdom - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - recruiting
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
This study explores how Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD) affects people's health. It aims to understand their main symptoms and care preferences, comparing them to people with bronchiectasis to improve support and future research.
United Kingdom - recruitingPHASE2
A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis
This study looks at a new drug, GSK3862995B, for adults with bronchiectasis. It aims to see if the drug is safe and effective in improving this long-term lung condition, compared to a dummy drug. We also check how people's bodies handle the medication.
United States · Argentina · China