- ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, parallel-group, Proof-of-Concept (PoC) study to assess the efficacy, safety and tolerability of itepekimab, in participants with non-cystic fibrosis bronchiectasis
This study is testing a new medicine, itepekimab, for people with bronchiectasis. It aims to see if the medicine can reduce flare-ups of their condition and if it's safe to use. Half the people will get the new medicine, and half will get a dummy medicine.
Italy · Czechia · Spain - active not recruitingPHASE2
Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine
This study is for adults with bronchiectasis who were in a previous trial with the medicine BI 1291583. It aims to see if this medicine helps long-term and how well people tolerate it. Participants take tablets daily and visit the clinic regularly.
United States · Australia · Belgium - recruitingPHASE3
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is looking into a new medicine, BI 1291583, for people with bronchiectasis. It aims to see if this medicine can help reduce flare-ups, which are common with the condition. Participants will take a tablet daily and be monitored for up to 1 year and 8 months.
United States · Argentina · Australia - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - recruitingPHASE1, PHASE2
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis
This study is looking at a new inhaler medicine, CHF6333, for people with bronchiectasis. It checks how safe it is and how the body handles it, in healthy people and those with the condition, both after single and repeated doses.
United Kingdom - recruiting
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
This study looks at breathing problems during sleep in people with long-term lung conditions like asthma or COPD. Researchers are using a new way to analyse sleep study data to better understand how these conditions affect sleep and breathing.
United Kingdom - authorisedTherapeutic use (Phase IV)
Enhancing Lung Health in Kids with structural Lung Damage and Malformations: a randomized controlled trial on Azithromycin (AZI) for Airway Infection Prevention
This study looks at whether a medicine called azithromycin can help children with certain lung problems get fewer chest infections. It compares azithromycin to a dummy medicine (placebo) to see if it makes a difference.
Denmark - recruiting
Health Impact of Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD)
This study explores how Non-Tuberculous Mycobacteria Pulmonary Disease (NTM-PD) affects people's health. It aims to understand their main symptoms and care preferences, comparing them to people with bronchiectasis to improve support and future research.
United Kingdom