Cardiovascular Disease research hub
19 indexed studies · 10 currently recruiting
- recruitingTherapeutic confirmatory (Phase III)
A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with pelacarsen (TQJ230) on major cardiovascular events in patients with established cardiovascular disease
This study tests a new injection called pelacarsen for adults with heart disease. Researchers want to see if lowering a specific blood fat, called lipoprotein(a), helps prevent serious heart problems like heart attacks and strokes. Half the participants will receive the medicine and half will receive a dummy injection.
Hungary · Czechia · Sweden - recruitingHuman Pharmacology (Phase I)- First administration to humans
A trial in healthy volunteers to study safety, tolerability, CS014-levels and effects in the body, after single and repeated doses of CS014, for the first time in humans.
Researchers are testing a new medicine called CS014 for the first time in healthy people. They want to see if it's safe, how much the body can handle, and what it does inside the body. This study is an important first step in developing treatments for heart and blood vessel conditions.
Sweden - authorisedTherapeutic confirmatory (Phase III)
A Double-blind, Randomized,Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants with Elevated Lipoprotein(a)
This study is looking at a new medicine called Olpasiran. It aims to see if Olpasiran can help prevent serious heart problems like heart attacks in people who have high levels of a specific fat in their blood called lipoprotein(a).
Spain · Hungary · Portugal - active not recruitingPHASE3
A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
This study looks at a new drug, AZD0780, for people with heart disease or who are at risk of it, and who have high 'bad' cholesterol (LDL-C). We want to see if AZD0780 safely lowers this cholesterol.
United States · Argentina · Australia - recruitingPHASE3
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
This study is looking into a new medication called AZD0780. It aims to see if this medicine can lower the risk of serious heart problems like heart attacks or strokes in people who have already had them, or in those at high risk of having one for the first time.
United States · Argentina · Brazil - completed
The safety and efficacy of using shorter ablation times during pulmonary vein isolation using a multielectrode radiofrequency balloon catheter
This UK study tests whether delivering shorter bursts of heat during a heart procedure called catheter ablation works well for atrial fibrillation. Researchers want to see if reducing treatment time from 20 seconds to under 7 seconds helps protect the nearby food pipe from heat damage while still correcting irregular heartbeats.
United Kingdom · England · Belgium - completedPhase IV
Web-based investigation of statin side-effects
Statins lower your risk of heart attacks and strokes, but many people stop taking them due to muscle aches. This UK study helps you find out if your muscle pain is really caused by statins. Over one year, you will test real statin tablets against dummy pills to compare your symptoms.
United Kingdom · England · Wales - recruiting
The Fish and Meat study
This study looks at how different diets (meat, fish, or vegetarian) affect heart health in overweight adults. Researchers want to see if eating fish is truly good for your heart, especially compared to eating red meat.
United Kingdom · Scotland - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - recruiting
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
This study in Germany looks at how well hospitals apply the latest guidelines for treating heart failure. It checks if specialist training helps doctors start and adjust heart medications quickly for patients with a specific type of heart failure before they leave the hospital.
Germany - active not recruitingNA
Pharmacist Case Finding and Intervention for Vascular Prevention Trial
This study looks at how pharmacists can help people lower their risk of heart disease. Heart disease is very common, and pharmacists often see patients. They might be able to help you understand and reduce your personal risk factors for heart problems.
Canada - not yet recruitingNA
HEARTS in Sync + CardioWatch 287-2
This study looks at how a wrist-worn device, the CardioWatch 287-2, helps people in a virtual heart rehabilitation program called HEARTS in Sync. It compares health improvements in those who use the device with those who don't, aiming for better care at home.
Canada - recruitingNA
Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty in Older Nova Scotians
This study looks at how a mix of protein, blueberries, and exercise can help older people in Nova Scotia reduce weakness and improve their heart health. It aims to see if these lifestyle changes can make a real difference.
Canada - not yet recruitingNA
Investigating the Effects of Green Tea on Blood Viscosity
This study looks at how green tea affects blood thickness in healthy people aged 65 and over. Researchers want to see if green tea can improve blood flow, which might help reduce the risk of heart and blood vessel problems. They will measure blood thickness before and after drinking green tea.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
Prognostic Performance of Quantitative Myocardial Perfusion Imaging Using H2[15O] Positron Emission Tomography in Coronary Artery Disease - The AQUA COR trial
This study is looking at a special heart scan called quantitative myocardial perfusion imaging using H2[15O] PET. It aims to see how well this scan can predict future heart problems like heart attacks or death in people with heart disease over up to 10 years. It will help doctors understand who is most at risk.
Sweden - not yet recruitingNA
Effectiveness of Pollution Monitoring in Clinical Exercise Rehabilitation
This study looks at whether real-time air pollution warnings can help people with heart and lung conditions exercise outdoors more safely. Participants will use an app that gives exercise tips and, for some, also shows local air quality to help them choose better times or places to walk.
United Kingdom - active not recruitingPHASE3
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
This study, called REDEFINE 3, investigates a new medicine, CagriSema, for people with heart and blood vessel diseases. It aims to see if CagriSema can reduce the risk of serious events like heart attacks and strokes.
United States · Argentina · Australia - active not recruiting
Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Patients
This study looks at how well a special new heart stent, called Ultimaster Nagomi™, works in people with complex heart problems. It aims to see if it helps reduce serious issues like heart attacks or needing another procedure after one year.
Austria · Belgium · Estonia - enrolling by invitationNA
Free Fatty Acid Effects In Type 2 Diabetes
This study looks at how omega-3 fatty acids, found in oily fish, might help people with type 2 diabetes and heart problems. Researchers want to see if omega-3s can improve blood sugar and reduce the risk of heart disease, as they are a natural and potentially safe option.
United Kingdom