- recruiting
A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions
This study is testing a simple breath-test to find liver cancer earlier and check on other liver conditions. It looks for tiny chemicals in your breath. You could join if you have liver cancer, cirrhosis, or certain other liver issues, or tummy problems with a normal liver scan.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Multicenter Study to Determine the Dose, Safety, Efficacy and Pharmacokinetics of TRK-950 when Used in Combinations with Selected Anti-Cancer Treatment Regimens in Patients with Selected Advanced Solid Tumors
This study is testing a new medicine, TRK-950, in adults with advanced cancers like bladder, bowel, stomach, and ovarian cancer. Researchers want to find the right dose, understand if it's safe, and see how well it works when given alongside other cancer treatments.
France - recruiting
In-Depth Characterisation of Biliary Strictures and Hepato-Pancreato-Biliary Focal Lesions for Development of New Technologies to Tackle Hepato-Pancreato-Biliary Cancers
This study aims to better understand cancers in the liver, bile ducts, and pancreas to find new ways to diagnose and treat them. Researchers are collecting samples to develop new technologies for earlier detection and more effective treatments for these challenging cancers.
United Kingdom - recruitingPHASE3
Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma
This study is testing a new medicine, Tinengotinib, for people with a type of bile duct cancer called cholangiocarcinoma. It's for those whose cancer has specific genetic changes (FGFR-altered) and hasn't responded to previous treatments, including an FGFR inhibitor drug. Researchers want to see if Tinengotinib is safe and works better than other treatments.
United States · Austria · Belgium - active not recruitingPHASE3
Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer
This study looks into a new chemotherapy combination (gemcitabine and cisplatin) compared to the usual care (capecitabine or observation) for people with certain bile duct or gallbladder cancers after surgery. We want to see if the new combination works better.
Australia · Austria · Denmark - recruiting
Deep Liver Phenotyping and Immunology Study
This study aims to find better ways to spot liver cancers early, especially in people already at risk. Researchers are looking for clues in blood, urine, and liver samples that could show who might develop cancer, helping doctors treat it sooner.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, double-blind, placebo-controlled, multi-center, randomized study evaluating LSTA1 when added to standard of care (SoC) versus standard of care alone in subjects with advanced solid tumors (BOLSTER)
This study is looking at a new treatment called LSTA1 for people with advanced head and neck cancer or a type of bile duct cancer (cholangiocarcinoma). It aims to see if adding LSTA1 to standard treatments is safe and helps people live longer and feel better.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of SGN-B7H4V in Advanced Solid Tumors
Researchers are testing a new medicine called SGN-B7H4V for several advanced cancers, including certain breast, lung, and ovarian cancers. This early-stage study aims to find a safe dose and see what effects it has. It's for adults whose cancer has spread or come back.
France · Spain · Italy - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-Label, Randomized, Active-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Gemcitabine Plus Cisplatin Chemotherapy in First-Line Treatment of Participants With Unresectable or Metastatic Cholangiocarcinoma With FGFR2 Rearrangement (FIGHT-302)
This study is testing a new drug, pemigatinib, against standard chemotherapy for a type of bile duct cancer (cholangiocarcinoma) that has spread or can't be removed, and has a specific gene change. It wants to see which treatment works better and is safer as a first treatment.
Germany · Belgium · Italy - recruitingNA
The Dragon PLC Trial (DRAGON-PLC)
This study looks at a new way to prepare people with certain liver cancers for surgery. It compares a standard procedure (PVE) with a new one (PVE + HVE) to see if more people can have life-saving surgery and live longer.
United States · Australia · Austria - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - authorisedPhase II and Phase III (Integrated)
68Ga-FAPI-46 PET for imaging of gastrointestinal cancers: A prospective interventional single-arm clinical trial (FAPI-PET-GI)
This study is testing a new type of scan, called a 68Ga-FAPI-46 PET scan, to see how well it finds different types of gut cancers. It compares the new scan to standard methods to see if it improves detection.
Germany - authorisedTherapeutic use (Phase IV)
ETCABio - Evaluation of Skin Tests in Biotherapy Allergies
This study looks at how your skin reacts to certain advanced cancer medicines, called biotherapies. We're finding the strongest dose that doesn't cause a skin reaction in most people when tested on the skin, to make these treatments safer.
France - recruitingPHASE3
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
This study looks at a daily tablet called ivosidenib for adults with bile duct cancer that has come back or spread, and has been treated before. It aims to confirm if the treatment is safe and works well, and how it affects quality of life.
Armenia · Australia · Austria