Chronic heart failure research hub

Randomized, controlled, double-blind trial to investigate the effect of colchicin on the endothelial function in patients with CHIP mutations and chronic heart failure with reduced left ventricular function (CHIP-HF)

This study looks at whether a medicine called colchicine can help people with a specific type of heart failure. It compares colchicine to a dummy pill to see impacts on blood vessel health, especially in those with certain genetic changes.

VItamiN D treatIng Chronic heArT Failure (the Effect of Vitamin D Supplementation in Patients With Heart Failure)

This study looks at whether a daily vitamin D supplement can help people with long-term heart failure and low vitamin D. Patients will receive either vitamin D or a dummy pill to see if it reduces hospital stays or improves their health over several years.

A trial to learn if itraconazole and carbamazepine affect how AZD5462 moves throughout the bodies of healthy adults

This study is looking at how a new medicine, AZD5462, moves through the body when healthy adults also take common medicines for fungal infections (itraconazole) or epilepsy/nerve pain (carbamazepine). It will help us understand how these medicines interact.

A Randomized Study in Healthy Participants to Identify the Optimal Subcutaneous Injection Strategy for COR-1167

This early-stage study is looking for healthy volunteers to help researchers figure out the best way to give a new medication, COR-1167, by injection under the skin. It's not for people with heart failure yet, but aims to make future treatments for chronic heart failure better.

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Preserved Ejection Fraction

A Phase IIb Two-cohort, Randomised, Placebo-controlled, Double-blind, Multi-centre, Dose-ranging Study of AZD5462 in Stable Patients with Chronic Heart Failure