Chronic myeloid leukemia research hub
6 indexed studies · 3 currently recruiting
- ongoing, recruitingTherapeutic exploratory (Phase II)
A phase II, single-arm study of de-escalation and treatment-free remission in patients with chronic myeloid leukemia treated with nilotinib in first-line therapy followed by a second attempt after nilotinib and asciminib combination: DANTE study
This study looks at stopping leukaemia medication (Tasigna, Scemblix) in two stages for people with chronic myeloid leukaemia (CML). It aims to see if patients can stay well without treatment after initial drug therapy, and what happens if they need to restart or switch medications.
Italy - ongoing, recruitingTherapeutic exploratory (Phase II)
Venetoclax after TKI to target persisting stem cells in CML
This study looks at a new way to treat Chronic Myeloid Leukaemia (CML). It's for people whose CML is well controlled with standard medicine. Researchers want to see if adding another drug, Venetoclax, can get rid of the remaining leukaemia cells that might be hiding in the bone marrow.
Germany - recruitingPHASE1
A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia
This study is looking at a new medicine called ELVN-001 for people with a type of blood cancer called Chronic Myeloid Leukaemia (CML). It aims to find the right dose and see how safe and effective it is, especially for those who haven't responded well to other treatments.
United States · Australia · Belgium - recruitingPHASE2
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
This study looks at restoring healthy gut bacteria in people with blood cancers before a stem cell transplant. We're testing special capsules (IMT) against a dummy capsule to see if they improve gut health and reduce common problems like infections after transplant.
United Kingdom - recruitingPHASE1, PHASE2
A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia (CARDINAL)
This study is testing a new medicine called TERN-701 for people with a type of blood cancer called Chronic Myeloid Leukemia (CML) that hasn't responded well to other treatments. It aims to check if the medicine is safe, what dose works best, and if it helps treat the cancer.
United States · Australia · France - authorisedTherapeutic exploratory (Phase II)
Safety and efficacy of treatment combination with ponatinib and asciminib in chronic myeloid leukemia patients resistant to ponatinib and/or asciminib
This study is looking at a new combination of two existing medicines, Scemblix and Iclusig, for people with chronic myeloid leukemia (CML). It aims to see how safe and effective this combination is when current treatments aren't working as well as they should.
Spain