Chronic Obstructive Pulmonary Disease research hub

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

This study looks at the long-term safety of a treatment called astegolimab for people with a lung condition called COPD. It's for people who have already taken part in previous studies of this drug.

A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD

This study is testing a new medicine, Verekitug, for people with moderate to severe COPD. It will check how well the medicine works and if it's safe. Participants will take Verekitug or a dummy pill alongside their usual COPD treatments.

Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD

This study is testing a new inhaled medicine, frespaciguat, for people with lung disease (COPD) and high blood pressure in their lungs (pulmonary hypertension). Researchers want to see if it helps people walk further.

A Pragmatic Real-world Multicentre Observational Research Study to Explore the Clinical and Health Economic Impact of myCOPD

This study looks at how a digital app called myCOPD can help people in the UK with a long-term lung condition called COPD. It aims to see if the app helps people recover faster after hospital stays and manage their condition better, especially in areas where healthcare support is harder to access.

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

This study is testing a new medicine, lunsekimig, for adults aged 40-80 with COPD that's not well-controlled. We want to see if it helps improve breathing, is safe, and has manageable side effects compared to a dummy medicine.

A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation

This study looks at a new inhaler (BGF MDI) for people with COPD and lung hyperinflation. We want to see how it affects heart and lung function compared to a dummy inhaler. It's for people aged 40-80 who smoke or used to smoke.

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

This study is testing a new medicine, lunsekimig, for people with COPD who still have symptoms even with current treatments. It aims to see if lunsekimig is safe and helps improve COPD, particularly for those with a specific type called an 'eosinophilic phenotype'.

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.

Innate Immunity in COPD

This study investigates why people with COPD have ongoing lung inflammation and difficulty fighting off bacteria. Researchers are looking at how immune cells in the lungs and blood get their energy, hoping to find new ways to treat COPD.

Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)

This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.

Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure

Eosinopenia in Severe COPD Exacerbation

This study looks at how a type of white blood cell, called eosinophils, changes in people with severe COPD flare-ups. We want to find out why some people have low levels of these cells when they're admitted to hospital, and how long it takes for these levels to return to normal.

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

This study looks at a new treatment called dupilumab for people aged 40-85 with a severe lung condition called COPD. It aims to see if the treatment reduces lung inflammation and improves breathing and quality of life.

Ryme Medical TLD Pilot Study

This study is looking at a new treatment called Targeted Lung Denervation (TLD) for people with a lung condition called COPD. It wants to see if the TLD treatment, using the Ryme Medical system, is safe and works well. This is a pilot study, meaning it's an early look at the treatment.

Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations

This study looks at how best to use azithromycin to prevent flare-ups in people with COPD. It compares continuing the medicine, stopping it completely, or stopping it only during summer months, to see which approach works best for patients.

A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD

This study looks at the long-term safety of a new medicine, itepekimab, for people with severe lung disease (COPD). It will also check if the medicine continues to help over time. Participants will have already been part of a previous study on this medicine.

Open-label, non-randomised, single-dose, one sequence, two-period, cross-over study to investigate the effect of inhibition of P-glycoprotein and breast cancer resistance protein transporters by cyclosporine on the pharmacokinetics of CHF6001 in healthy volunteers.

This study looks at how a drug called CHF6001 works in the body and if another medicine, cyclosporine, changes it. We want to understand how these drugs interact so we can use them safely and effectively, especially for people with breathing problems like COPD.

An Open Label Study to Assess the Effect of Patient Use and Robustness on Tiotropium Bromide Spray 2.5μg, Soft Mist Inhaler device

This study is looking at an inhaler used by people with a lung condition called COPD. Researchers want to see how well a specific inhaler works when people use it, and how sturdy the inhaler device is during normal use. It's an early-stage study to understand the inhaler better.

The impact of extra-fine inhalation corticosteroid particles on small-airway disease in Chronic Obstructive Pulmonary Disease (COPD): a randomized, prospective cross-over trial.

This study is looking at how a specific type of asthma and COPD spray (inhaler) with very tiny medicine particles might help people with Chronic Obstructive Pulmonary Disease (COPD). It wants to see if these small particles can reach the smaller airways in the lungs better and improve breathing.

PASS to Assess Cardiovascular and Cerebrovascular Events in COPD Patients Initiating Fixed Triple Therapy (DPI or pMDI)

This study looks at the safety of two types of inhalers (DPI and pMDI) for people with COPD who are starting a new 'triple therapy' medicine. It checks if there are differences in heart or stroke-related problems between the two inhaler types.

A Double Blind, Multicentre, Randomised Three-Period, Three-Treatment, Cross-Over Study To Evaluate The Effect of BGF MDI, BFF MDI and Placebo MDI on Exercise Parameters In Participants with Chronic Obstructive Pulmonary Disease (ATHLOS)

Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients (COPD-LIVE)

THE ANTES B+ STUDY: AN OPEN-LABEL, PRAGMATIC, RANDOMIZED, CONTROLLED TRIAL OF TRIPLE THERAPY VERSUS LABA-LAMA COMBINATION TO IMPROVE CLINICAL CONTROL IN HIGH-RISK GOLD B PATIENTS (B+)

A Phase 2a, open-label, two-part study to evaluate the mechanism of action of itepekimab (anti-IL-33 mAb) on airway inflammation in patients with chronic obstructive pulmonary disease (COPD)

Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE)

An Open-label, Single-group, Three-period, Fixed-sequence, Phase I Study to Assess the Pharmacokinetics of AZD6793 Tablets When Administered Alone and in Combination with Itraconazole Capsules in Healthy Adult Female and Male Participants

Randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/REGN3500/itepekimab (anti-IL-33 mAb) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) (AERIFY-1)

Randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/REGN3500/itepekimab (anti-IL-33 mAb) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)

Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa (MORPHEUS I/IIa)

Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels

This study looks at how a common COPD medication (budesonide) affects people, depending on their eosinophil levels and lung germs. It aims to understand why some patients respond better than others to this treatment.