- active not recruitingPHASE4
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.
This study looks at whether a blood pressure medicine called a beta-blocker can prevent bleeding from small swollen veins (varices) in the food pipe for people with liver scarring (cirrhosis). Currently, we only know beta-blockers work for large varices. This research aims to find out if they help with small ones too.
United Kingdom - active not recruitingPHASE1, PHASE2
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
This study looks into a new treatment called RTX001 for severe liver disease like cirrhosis. It's made from your own cells and aims to reduce inflammation and scarring in the liver. This is the first time it will be tested in people to see if it's safe and effective.
Spain · United Kingdom - recruiting
CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome
This study looks at how liver diseases are linked to alcohol or unhealthy eating habits. Researchers want to understand why some people develop liver cancer, even in early stages, by studying health factors, body scans, and liver samples.
France - recruiting
DELIVER Study in a Population With Clinical Suspicion of Liver Cirrhosis
This study, called DELIVER, is looking for a new breath test to find liver scarring (cirrhosis) earlier. It involves taking a special drink and then breathing into a machine to see how your body processes it. This could help doctors spot liver problems sooner.
United States · Chile · United Kingdom - recruiting
Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation
This study looks at how high pressure in the tummy area (intra-abdominal hypertension) might lead to tiny bits of stomach contents going into the lungs (microaspiration) in very sick patients with liver scarring (cirrhosis) who are on a breathing machine.
France - active not recruitingPHASE3
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
This study is looking at a new medicine called resmetirom for people with a type of liver scarring called NASH cirrhosis. It aims to see if the medicine can prevent serious liver problems or death over about three years, compared to a dummy pill.
United States · Belgium · Canada