- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase 1, randomized, double-blind, placebo-controlled study investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending doses of VNA-318 in healthy male subjects
This early-stage study is looking at a new medicine called VNA-318 for problems with thinking and memory. We want to see if it's safe for healthy men, how much of it stays in the body, and what it does. It's a first step in testing this new treatment.
France - active not recruitingPHASE2
METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia
This study looks at whether changing your lifestyle and taking a diabetes drug called metformin can help older adults at risk of memory problems stay healthy and independent, and reduce their risk of developing dementia.
Finland · Sweden · United Kingdom - recruitingNA
Stepcare Extended Follow-up Substudy
This study looks at how people recover for a long time after a serious cardiac arrest and how different treatments affect their memory and thinking. It also checks how caring for these survivors affects their family.
Australia · Belgium · Finland - not yet recruiting
Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk
This study looks at confusion and memory problems some older people experience after surgery. We're testing how best to study these issues and see if memory tests and blood samples can help us understand why they happen, aiming to make surgery safer for the brain.
United Kingdom - active not recruitingNA
Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders
This study looks at a new online programme called RC2S+ for people with schizophrenia and similar conditions. It aims to see if using this programme distantly is practical and helpful for improving social thinking skills.
Canada - active not recruiting
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study looks at how memory and thinking skills (cognition) change after hip or knee replacement surgery. Researchers want to understand these changes better, identify who might be at higher risk, and find ways to improve recovery. It focuses on changes that might last longer than a few months.
Canada - active not recruiting
Biomarkers Associated With Postoperative Cognitive Dysfunction
This study looks at ways to predict and understand problems with thinking and memory after surgery in people over 65. Researchers are measuring brain activity during surgery and checking blood for certain proteins to see if they can spot who might develop issues like confusion or memory troubles.
United Kingdom - recruitingNA
The Effect of Upper Limb Low-intensity Motor Control Training Program on Cognitive Function in Healthy Older Adults
This study looks at whether special arm exercises can improve how older adults move and think. It aims to see if these exercises can help people aged 65-85 stay sharp and active.
United Kingdom - not yet recruitingPHASE3
A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia
This study is looking at how a new medicine, Xanomeline/Trospium (XT), affects thinking and memory in adults with schizophrenia over one year. XT is already approved for treating other symptoms but this study focuses on cognitive benefits.
Austria · Belgium · Czechia - recruitingNA
The Role of Cognition in Motor Learning After Stroke
This study looks at how memory and attention affect arm recovery after a stroke. It uses a special virtual reality game with magnified feedback to help people improve their arm movement, hoping to find better ways to help stroke survivors regain arm function.
Canada - recruitingNA
Feasibility of Web-based Therapy Sessions
This study looks at using a special website, "Cognishine," for speech and thinking rehabilitation in adults after a brain injury or critical illness. It checks if this online approach is practical and helpful in NHS hospitals.
United Kingdom - recruiting
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
This study is developing a new, easy-to-use digital test (IC3) to better understand how stroke affects memory and thinking skills. It aims to help doctors give the right support to stroke survivors, using brain scans and blood tests alongside the new cognitive assessment.
United Kingdom - recruiting
Visual Frailty in Ageing
This study looks at 'visual frailty' in older people with a common eye condition called AMD. Researchers want to understand and measure how vision problems, general health, and mental well-being are linked, to help improve care for ageing eyes.
United Kingdom - recruiting
Leg Ischaemia Management Collaboration
This study looks at how many people with severe leg circulation problems need an amputation within a year. It compares care before and after a new special clinic was set up to help save limbs.
United Kingdom - enrolling by invitation
Estimating Premorbid Intellectual Functioning in Children and Measuring Change in Cognitive Functioning as Children Develop
This study aims to improve how we measure thinking skills in children. By testing healthy children twice, researchers hope to create better tools to track changes in brain function after injuries or illnesses, ensuring children get the right support to develop well.
United Kingdom