Breast cancer research hub

DPDIMP#1-trial: Impact of DPYD gene test on the safety and efficacy of fluoropyrimidine therapy

This study looks at how a gene test can make common cancer medicines for breast and colon cancer safer and work better. We're testing different forms of these medicines and checking how they move through the body to find the best and safest ways to treat patients.

Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)

This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.

Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS

This study is testing a new injection, IP-001, after a heat treatment called thermal ablation for certain advanced cancers (bowel, lung, soft tissue sarcoma) that haven't responded to previous treatments. It aims to see if it's safe and effective, potentially offering a new treatment option.

Advanced Pelvic Surgical Oncology Database - Prospective Observational Study

This study looks at people in Glasgow having complex surgery for cancers in the tummy and pelvis, like bowel or gynaecological cancers. We're observing their recovery and health over time to understand common problems and improve future care.

Cancer Loyalty Card Study 2 (CLOCS-2)

This study looks at shopping habits using loyalty card data from Tesco or Boots to see if certain purchases might hint at cancer earlier. It aims to help doctors diagnose pancreatic, bowel, oesophageal, stomach, liver, bladder, womb, vulval, and ovarian cancers sooner.

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

This study looks at a new drug, selpercatinib, for advanced cancers, including certain lung, thyroid, and other solid tumours that have a specific genetic change called a RET alteration. Researchers want to check its safety, how it works in the body, and if it helps shrink tumours.

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.

EPA for Metastasis Trial 2

Effect of perioperative intravenous infusion of lidocaine on the postoperative course and the immune response in patients undergoing surgery for colon cancer - the PILDI study

This study is looking at whether giving a common pain medication called lidocaine through a drip during colon cancer surgery can help reduce strong painkiller use afterwards. Researchers want to see if lidocaine can help patients recover better and need less opioid medication.

LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy