colorectal cancer research hub

A phase 2, single arm, open label, study on the safety and feasibility of Liver Isolated Oxaliplatin (LIOX) delivered via arterial access device for treatment of liver metastasis in colorectal cancer patients

This study looks at a new way to treat colorectal cancer that has spread to the liver. It's testing a chemotherapy drug called oxaliplatin delivered directly to the liver to see how safe and effective it is.

Triple Assay of Rectal Mucus in the Diagnosis of Colorectal Cancer

This study is testing a new Oricol Test for bowel cancer. It looks at a mucus sample from your bottom to find signs of cancer or pre-cancerous growths (polyps) in people referred for urgent checks. The aim is to find a faster, easier way to detect these conditions.

First CORRECT Study of Minimal Residual Disease (MRD) Detection in Colorectal Cancer

This study looks at a new way to check if bowel cancer has completely gone after surgery. It involves regular blood tests for up to five years for people who have had their stage 2 or 3 bowel cancer removed. Doctors hope to find very small amounts of cancer cells to help improve treatment.

Tracking Mutations in Cell Free Tumour DNA to Predict Relapse in Early Colorectal Cancer

This study looks at new ways to predict if bowel cancer might come back after surgery using blood tests. It also explores if these blood tests can safely guide chemotherapy decisions, helping some patients avoid unnecessary treatment while keeping it effective for others.

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

This study looks at a new drug, Dato-DXd, by itself and with other treatments for different advanced cancers like those affecting the stomach, ovaries, and prostate. It checks if the treatment is safe and effective.

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

This study looks at a new drug, zongertinib, for different HER2+ cancers that have spread. Researchers want to find the best dose, alone and with other treatments, to see if it can shrink tumours.

Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.

This study looks at whether we can find signs of non-bowel cancers, like lung or pancreatic cancer, in a small sample of mucus taken from a person's bottom. We're testing a new, simple device to see if it can help detect these cancers earlier.

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

This study is testing a new medicine, GDC-6036, for people with advanced cancers that have a specific genetic change called KRAS G12C. It will look at how safe the medicine is and if it helps shrink tumors, sometimes combined with other treatments.

COLO-COHORT (Colorectal Cancer Cohort) Study

This study aims to find better ways to predict who is at high risk of bowel cancer or pre-cancerous growths. Researchers will look at health factors, new stool tests, and gut bacteria to create a more accurate risk prediction tool, helping to detect problems earlier.

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

This study is testing a new drug, VVD-133214, for advanced solid tumours, including a type of bowel cancer. It looks at safety, how the body handles the drug, and if it can help shrink tumours. It's an early-stage study, sometimes testing the new drug with other standard treatments.

Chemo Brain Prehab Project

This study looks at whether a special exercise programme can help older people with colorectal cancer who are having chemotherapy. It aims to reduce 'chemo-brain' – problems with memory and thinking – and improve how well people feel overall during and after treatment.

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.

Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer

This study compares two treatments, XL092 (plus atezolizumab) and regorafenib, for advanced bowel cancer that has spread. It's for people whose cancer hasn't responded well to previous common treatments. We want to see which treatment works better to control the cancer.

A Study of MGC026 in Participants With Advanced Solid Tumors

This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.

Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours

This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.

REVOLUTION Surgery (REVOLUTION Surgery)

This study looks into why some cancer patients lose weight and muscle, a condition called cachexia. It aims to understand this problem better by gathering information from patients undergoing surgery for certain cancers and comparing it with people having surgery for non-cancer conditions.

Cancer Surveillance and Support

This study helps people who have had breast or bowel cancer after their treatment. It looks at using an online system for survivors to report health changes from home and get quick advice. The goal is better support and faster help when needed.

Calcium electroporation in combination with irreversible electroporation and immunotherapy in patients with pMMR metastatic colorectal cancer - A prospective, phase 2 study

A Phase I study to evaluate the safety and dosimetry of 68Ga-labelled OncoFAP derivatives in patients with solid tumors

Randomized Phase 2 Study of DKN-01 Plus FOLFIRI/FOLFOX and Bevacizumab Versus FOLFIRI/FOLFOX and Bevacizumab as Second-line Treatment of Advanced Colorectal Cancer (DeFianCe)

CA209-8KX Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy

AN OPEN-LABEL, MULTICENTER, PHASE 1a/1b STUDY OF IGM-8444 AS A SINGLE AGENT AND IN COMBINATION IN SUBJECTS WITH RELAPSED, REFRACTORY, OR NEWLY DIAGNOSED CANCERS

An open-label, multicenter, phase 1b/2 study of E7386 in combination with pembrolizumab in previously treated subjects with selected solid tumors

A Phase 3 study of MK-4280A (coformulated favezelimab [MK-4280] plus pembrolizumab [MK-3475]) Versus Standard of Care in Previously Treated Metastatic PD-L1 positive Colorectal Cancer (KEYFORM-007)

Phase II trial of Pembrolizumab and Olaparib in homologous-recombination deficient (HRD) advanced colorectal cancer (CRC).

Transversus Abdominis Plane (TAP) Block vs. Laparoscopic Port Site Wound Infiltration in Patients with Colorectal Cancer Undergoing Scheduled Laparoscopic Surgery Included in the Enhanced Recovery After Surgery (ERAS) Program

A Phase 1b, Multicenter Study to Determine the Dose, Safety, Efficacy and Pharmacokinetics of TRK-950 when Used in Combinations with Selected Anti-Cancer Treatment Regimens in Patients with Selected Advanced Solid Tumors

ORGAN SPARING FOR LOCALLY ADVANCED RECTAL CANCER AFTER NEOADJUVANT TREATMENT FOLLOWED BY ELECTROCHEMOTHERAPY - LARC_ DEEP_CANCERS

Ipilimumab and nivolumab plus temozolomide and capecitabine for patients with chemo-refractory pMMR, MGMT silenced metastatic colorectal cancer: The MAYA2 trial

SPECT/CT imaging of FPI-2505 in patients with solid tumours; a phase 0 molecular imaging basket trial (SCOPE-study).

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.

Optimising Colorectal Cancer Patient Pathways

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.

The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling

This study is developing new blood tests for early cancer detection and to monitor how well treatment is working. It uses artificial intelligence to look at tiny particles in blood samples from people with various cancers and healthy volunteers.

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)

This study looks at new drug combinations for advanced bowel cancer that has specific genetic markers (MSI-H or dMMR). It compares these combinations with existing treatments to see if they are more effective and safe for patients.

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.

A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors

COlorectal BReath Analysis (COBRA2)

This study is developing a new breath test for bowel cancer. It aims to help doctors find bowel cancer earlier, especially in people with unclear symptoms. Detecting it early means treatment can start sooner, improving chances of recovery.

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

This study looks at a new drug, sacituzumab tirumotecan, alone or with other common treatments for advanced bowel, pancreatic, and bile duct cancers. Researchers want to see if it's safe, tolerable, and can shrink these cancers.