- authorisedHuman Pharmacology (Phase I)- First administration to humans
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors (FiREBOLT)
The FiREBOLT study is testing a new cancer medicine, LY4337713, for the first time in humans. It is for adults with certain solid tumours—such as breast, bowel, or stomach cancer—that carry a protein called FAP. The main goal is to check its safety and find the right dose.
Germany · Netherlands - recruitingPHASE3
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
This study compares two treatments for advanced left-sided bowel cancer that hasn't spread. It looks at how long people stay disease-free when given a new drug called amivantamab with chemotherapy, versus a standard drug called cetuximab with chemotherapy.
United States · Belgium · Brazil - recruitingPHASE3
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
This study is for people with advanced bowel cancer where previous chemotherapy hasn't worked. It compares a new drug called amivantamab, plus standard FOLFIRI chemotherapy, against other established treatments (cetuximab or bevacizumab) with FOLFIRI, to see which works best.
United States · Australia · Belgium - recruitingPHASE3
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
This study is testing if a new combination of medicines, including tucatinib, works better than current treatments for people with advanced HER2-positive bowel cancer. It also looks at side effects. Participants will be randomly assigned to receive either the new combination or standard care.
United States · Argentina · Australia - active not recruitingPHASE2
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors
This study is testing a new cancer medicine called tisotumab vedotin for different solid tumours, including bowel, lung, pancreas, and head and neck cancers. It's looking to see how well it works alone or with other treatments, and what side effects might happen. The study has now moved into a longer-term phase.
United States · Canada · France - recruitingNA
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
This study compares two ways to check for colon polyps in people aged 65-82: a bowel scope (colonoscopy) or a simple stool test. We want to see which method works best and is safest for older adults who've had polyps before.
United States · Canada - recruitingPHASE4
TES RCT Fleet Enema vs Oral Mechanical Bowel Prep
This study compares two ways to clean the bowel before a special type of surgery called Transanal Endoscopic Surgery (TES). Researchers want to see if a liquid given into the bottom (enema) works better or worse than a drink (oral preparation) for cleaning the bowel, making surgery safer.
Canada - recruiting
Establishment of a Tumor Bank for Blood Samples
This study is setting up a collection of blood samples from people with cancer and healthy volunteers. This collection, called a tumour bank, will help scientists understand cancer better and develop new treatments in the future.
Austria · Belgium · Germany - recruitingPHASE3
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
This study is testing a new way to help surgeons see bowel cancer more clearly during operations. It compares a special dye, SGM-101, with standard viewing methods to find cancer cells in and around the bowel.
United States · Germany · Italy - recruitingPHASE1, PHASE2
HTL0039732 in Participants With Advanced Solid Tumours
This study is testing a new drug, HTL0039732, alone and with another cancer medicine, atezolizumab. It's for people with advanced solid tumours, aiming to see if blocking certain signals can help the immune system fight cancer. The goal is to find the right dose and see how well it works.
United Kingdom - recruitingNA
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers
This study looks at using MRI scans for sigmoid colon cancer to see if it helps doctors plan better treatment. Half of patients get standard care (CT scan), and the other half get an additional MRI. We compare how plans change and follow up for improved care.
United Kingdom - recruitingPHASE3
Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver
This study is looking at a new way to treat bowel cancer that has spread only to the liver. It combines standard chemotherapy with newer targeted drugs, and a special way of delivering chemotherapy directly to the liver, to see if it works better.
Belgium · France - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This study looks at two drugs called dabrafenib and trametinib for various cancers with a specific gene change (BRAF V600). These drugs are already approved for some cancers and researchers want to see if they can help people with other rare cancers or cancers with this same change.
United Kingdom - recruitingNA
Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.
This study looks at whether using a computer during a colonoscopy can help to find and remove growths in your bowel. This might lower your chance of getting cancer later, by making sure any worrying growths are caught early.
France - active not recruitingPHASE1
A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors
This study is testing a new drug, PF-08046049/SGN-BB228, for advanced melanoma and other difficult-to-treat solid cancers. It aims to find a safe dose and see how well it works, as well as checking for side effects.
United States · Canada · France - recruitingPHASE1, PHASE2
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
This study is testing a new drug, UCB4594, for advanced cancers. It's the first time it’s being used in people. Researchers want to find the safest dose, understand side effects, and see if it can shrink certain tumours by helping the body's immune system.
United Kingdom - recruitingPHASE3
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
This study is testing a new medicine, PF-08634404, alongside standard chemotherapy for adults with colorectal cancer that has spread. We want to see if this new combination helps more than an existing treatment with chemotherapy for people whose cancer has returned or spread.
United States · Argentina · Australia - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
This study is for adults with specific cancers that have a change called BRAF V600. It's testing if two drugs, vemurafenib and cobimetinib, already used for a type of skin cancer, can help treat these other cancers. The goal is to find new treatments for patients.
United Kingdom - active not recruitingPHASE1, PHASE2
A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
This study is testing a new drug, E7386, alongside other cancer medicines. It aims to find the safest and most effective dose for people with various solid tumours, especially endometrial cancer, and to understand how these combinations work.
United States · Canada · China - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
This study is testing a cancer drug called atezolizumab in people with certain cancers that have specific genetic changes. Atezolizumab is already used for some cancers, and this study wants to see if it can help other types of cancer that share these same genetic features.
United Kingdom - recruitingNA
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
This study looks at using special MRI scans to find bowel cancer that has spread to the liver early. It's for people with a high-risk type of bowel cancer who don't already have liver spread showing on CT scans. The aim is to see if these extra MRI scans help find hidden spread sooner.
United Kingdom - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations
This study is testing if two drugs, trastuzumab and pertuzumab, can treat different types of cancer beyond breast cancer. These drugs work by targeting a specific change in cancer cells called HER2. It's for people aged 12 and over with HER2-positive cancers.
United Kingdom - authorisedHuman Pharmacology (Phase I)- First administration to humans
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
This study is testing a new medicine called LY4257496 for people with certain types of cancer, including breast, bowel, prostate, and womb cancer, especially if it has spread. It's the first time this medicine is being given to people, to check if it's safe and how it works in the body.
Germany - recruitingPHASE1
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
This study is for adults with advanced cancers in places like the lungs or stomach that are hard to treat or have spread. It's testing a new drug, PF-08046050, to see if it's safe and helps shrink these cancers, sometimes with other medicines.
United States · Canada · China