- recruitingPHASE3
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients
This study looks at whether high doses of vitamin D3 can help seriously ill adults in intensive care, especially those with very low vitamin D. Previous research hinted it might reduce deaths in this specific group, and this new study aims to confirm if it’s a safe and effective treatment.
Austria · Belgium · Germany - recruiting
Using sEMG of the Diaphragm to Assess Readiness for Extubation
This study looks at a new way to see if critically ill patients are ready to have their breathing tube removed. It uses a special sensor on the skin to check how well a muscle called the diaphragm is working, hoping to make this important step safer and more successful.
United Kingdom - recruiting
Intensive Care Decision-making, Survival and Dying Well
This study explores intensive care survivors' experiences to understand how their past treatment and wishes about end-of-life care would influence their decision to have intensive care again, considering different chances of survival and quality of life.
United Kingdom - active not recruiting
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This study looks at the health of people in England and Wales one year after they left intensive care for COVID-19. Researchers will compare their health to people who were in intensive care for other reasons. The aim is to understand long-term health effects.
United Kingdom - recruiting
MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)
This study looks at how muscle weakness in the mouth and throat affects swallowing in very unwell adults in intensive care. It aims to understand why this happens and find better ways to help them eat and drink safely.
United Kingdom - not yet recruiting
Mitochondrial Assessment in Critical Ill Patients in Intensive Care
This study looks at how critical illness affects tiny parts of our cells called mitochondria, which produce energy. We're trying to find a simple breath test to check their function in very sick patients on breathing machines in intensive care, which could help guide future treatments.
United Kingdom - authorisedTherapeutic use (Phase IV)
A single-centre, partially blind, randomised, parallel-group, two-arms, superiority study to compare the efficacy and safety of extended (3 h) and intermittent infusion (0.5 h) of β-lactams (cefepime, ceftriaxone, meropenem, piperacillin/tazobactam) in critically ill paediatric patients (PEBBLE)
This study looks at how best to give antibiotics (like cefepime or meropenem) to very sick children with infections. Researchers compare giving these medicines slowly over a longer time versus quickly over a short time, to see which way works better and is safer for children.
Hungary