- not yet recruitingNA
MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO)
This study uses special MRI scans to understand how a medication called linaclotide affects digestion in adults with Cystic Fibrosis (CF). Many people with CF experience gut problems like bloating and constipation. Linaclotide helps the gut release more fluid, making things move easier. This research will check if MRI scans can reliably measure these changes.
United Kingdom - not yet recruitingNA
SPutum Induction and Nebuliser deviCEs for Patients With CF
This study looks at two different devices (nebulisers) to help people with cystic fibrosis (CF) produce sputum (phlegm) when they can't do it naturally. It checks if the devices work well, how easy they are to use, and how comfortable participants find them. This helps future research.
United Kingdom - not yet recruitingNA
Remote Exercise to Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis (RHH-CF)
This study looks at a home exercise program for adults with Cystic Fibrosis (CF). It aims to see if remote exercise can boost physical activity and improve heart health markers, as people with CF are now living longer with better treatments.
United Kingdom - not yet recruiting
Heart and Blood Vessels Health in People With Cystic Fibrosis
This study looks at the heart and blood vessels in people with Cystic Fibrosis (CF). We want to see how healthy they are and how new CF medicines might affect them over time. The goal is to understand heart risks better and find ways to prevent heart problems in people with CF.
United Kingdom - recruitingPHASE2
A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.
This study is testing a new capsule, NHS7108, for people with Exocrine Pancreatic Insufficiency (EPI). It compares the new medicine to a standard treatment (Zenpep®) to see how safe it is and how well it helps the body digest food.
United States · Bulgaria · Hungary - recruiting
MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis
This study looks at new ways to check lung health in people with cystic fibrosis, using special scans and breathing tests. It aims to understand how lungs change over time to help improve care. It's for people with CF aged 1 and up.
United Kingdom - recruiting
A Study of Females With CF Throughout Pregnancy and Post-partum, and Follow up of Their Offspring
This study looks at the health of women with cystic fibrosis (CF) before, during, and after pregnancy, and the health of their children. It aims to create better guidelines for families and doctors. This takes place at Royal Brompton Hospital.
United Kingdom - not yet recruiting
A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis
This study aims to improve how we diagnose Cystic Fibrosis (CF), especially for people with unclear results from standard tests. Researchers are developing new tests using 'mini-organs' grown from a small gut sample to get a more accurate diagnosis and find the best individual treatments.
United Kingdom - recruiting
Novel Sensors and Artificial Intelligence for Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis and Bronchiectasis
This study looks at new wearable sensors and AI to spot chest infections early in adults with cystic fibrosis or bronchiectasis. We'll track body changes like heart rate during antibiotic treatment. The goal is to see if these sensors can detect worsening conditions before they become obvious.
United Kingdom - recruiting
Understanding Inflammation, InFection and Interventions in Severe Exacerbations of Cystic Fibrosis
This study aims to understand how severe flare-ups (exacerbations) in people with cystic fibrosis are treated and why treatments work differently for some. Researchers will track symptoms, lung function, and collect samples to improve future care.
United Kingdom - recruitingEARLY_PHASE1
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis
This study is looking at how a medicine called linaclotide moves through the gut. It's already approved for constipation, and researchers want to see if it could help people with cystic fibrosis. They're using MRI scans in healthy volunteers to understand exactly how it works in the small and large bowel.
United Kingdom - recruiting
Identifying the Causes and Risk Factors of Pulmonary Exacerbations in Cystic Fibrosis
This study, called CF-Tracker, looks into what causes flare-ups for people with cystic fibrosis (CF). Researchers want to understand why these flare-ups happen and how to prevent them. It involves adults and some children with CF providing health information and samples over 12 months.
United Kingdom