Cystic Fibrosis (CF) research hub

Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis

This study is looking at how a medicine called linaclotide moves through the gut. It's already approved for constipation, and researchers want to see if it could help people with cystic fibrosis. They're using MRI scans in healthy volunteers to understand exactly how it works in the small and large bowel.

Understanding Inflammation, InFection and Interventions in Severe Exacerbations of Cystic Fibrosis

This study aims to understand how severe flare-ups (exacerbations) in people with cystic fibrosis are treated and why treatments work differently for some. Researchers will track symptoms, lung function, and collect samples to improve future care.

Identifying the Causes and Risk Factors of Pulmonary Exacerbations in Cystic Fibrosis

This study, called CF-Tracker, looks into what causes flare-ups for people with cystic fibrosis (CF). Researchers want to understand why these flare-ups happen and how to prevent them. It involves adults and some children with CF providing health information and samples over 12 months.

Remote Exercise to Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis (RHH-CF)

MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis

This study looks at new ways to check lung health in people with cystic fibrosis, using special scans and breathing tests. It aims to understand how lungs change over time to help improve care. It's for people with CF aged 1 and up.

A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency.

This study is testing a new capsule, NHS7108, for people with Exocrine Pancreatic Insufficiency (EPI). It compares the new medicine to a standard treatment (Zenpep®) to see how safe it is and how well it helps the body digest food.

A Study of Females With CF Throughout Pregnancy and Post-partum, and Follow up of Their Offspring

This study looks at the health of women with cystic fibrosis (CF) before, during, and after pregnancy, and the health of their children. It aims to create better guidelines for families and doctors. This takes place at Royal Brompton Hospital.

A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis

This study aims to improve how we diagnose Cystic Fibrosis (CF), especially for people with unclear results from standard tests. Researchers are developing new tests using 'mini-organs' grown from a small gut sample to get a more accurate diagnosis and find the best individual treatments.

Novel Sensors and Artificial Intelligence for Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis and Bronchiectasis

This study looks at new wearable sensors and AI to spot chest infections early in adults with cystic fibrosis or bronchiectasis. We'll track body changes like heart rate during antibiotic treatment. The goal is to see if these sensors can detect worsening conditions before they become obvious.