Neurodegenerative disease research hub
13 indexed studies · 5 currently recruiting
- authorisedTherapeutic exploratory (Phase II)
Influence of Dexmedetomidine on the Human Glymphatic Cerebrospinal Fluid Flow, Neural Activity and Cerebral Blood Flow in Functional Magnetic Resonance Imaging (GlymphDex)
This study looks at how a medicine called Dexdor affects brain activity, blood flow, and how fluid moves in the brain, especially when people are more or less conscious. We want to understand how this medicine works in different brain conditions like dementia.
Finland - recruiting
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
This study, called VESPAR, looks at how blood flow in the brain affects thinking problems like dementia, depression, and stroke. Researchers want to find better ways to measure brain blood flow and understand how it changes in different conditions to help plan future research.
United Kingdom - recruiting
DElirium and LIGHT: Exploring Modifiable Risk Factors of Delirium - a Pilot Study
This study, called DELIGHT-P, looks into why some critically ill patients become confused and have trouble thinking, a condition called delirium. We believe changes in a person's natural body clock, possibly due to light exposure, play a role. We're testing if light levels and body clock markers are linked to delirium, hoping to find better ways to help patients.
United Kingdom - active not recruitingNA
Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium
This study looks at whether changing how a common calming medicine is given during heart surgery can reduce confusion and memory problems afterwards. It compares using less of this medicine (benzodiazepine) with using it as usual, to see if it helps patients recover better.
United States · Canada - active not recruitingNA
Pilot Clinical Trial of an Integrative Intervention to Improve Critically Ill Patients' Delirium and Related Outcomes
This study looks into whether a combination of relaxation, guided imagination, and gentle massage can help critically ill patients reduce confusion (delirium) and improve how they feel. It's a small study to see if these methods are helpful and practical.
Canada - active not recruiting
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study looks at how memory and thinking skills (cognition) change after hip or knee replacement surgery. Researchers want to understand these changes better, identify who might be at higher risk, and find ways to improve recovery. It focuses on changes that might last longer than a few months.
Canada - recruiting
Electroencephalography and Sleep Quality With Lormetazepam in the Intensive Care Unit
This study looks at how a medicine called lormetazepam affects brainwave patterns (EEG) in very unwell patients in intensive care. Researchers want to see if it improves sleep and how deeply sedated patients are.
Germany - active not recruiting
Biomarkers Associated With Postoperative Cognitive Dysfunction
This study looks at ways to predict and understand problems with thinking and memory after surgery in people over 65. Researchers are measuring brain activity during surgery and checking blood for certain proteins to see if they can spot who might develop issues like confusion or memory troubles.
United Kingdom - recruiting
Retrospective Evaluation of Delirium Data From Previous Study Patients for Studies at the Clinic for Anesthesiology and Intensive Care Medicine CCM/CVK/CBF
This study looks back at patient records from previous studies at a specific anaesthesia clinic. Researchers are gathering information about delirium in patients aged 18-100 to understand what causes it. They're particularly interested in how delirium after surgery affects older men and women differently.
Germany - active not recruiting
PupillOmetry for Prediction of DelirIUM
This study looks at whether a new eye scanner can help doctors predict delirium (severe confusion) in seriously ill patients in intensive care. If successful, it could help identify patients at risk early, leading to better care.
France - recruiting
Enhancing care for delirium in palliative care units
This study aims to improve care for acute confusion (delirium) in hospices across the UK. We're testing new ways to help hospices follow guidelines better, hoping to reduce delirium and improve life quality for patients and their families.
United Kingdom · England · Wales - recruitingPHASE4
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
This study looks at whether a medicine called Dexmedetomidine can help prevent memory problems and confusion after heart surgery. Researchers want to see if it improves recovery and reduces how long people stay in hospital.
Canada - active not recruiting
Delirium in Children Undergoing Stem Cell Transplantation
This study looks at a temporary change in thinking called delirium in children having stem cell transplants. We want to find out how often it happens, why it happens, and how it affects children, aiming to reduce it. It's for children aged up to 21 undergoing this treatment.
United States · Canada