- recruitingNA
TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety
This study is looking at a mobile phone app called TrueBlue. It aims to see if the app can safely and helpfully monitor feelings of depression and anxiety in pregnant women and new mothers in Nottinghamshire. We want to find out how easy it is to use and if it works well.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingNA
Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.
This study looks at whether a special nutritional drink, 'Think Tank', can help middle-aged women aged 40-60 think more clearly after stressful experiences. Researchers will compare it to a dummy drink to see if it improves memory, attention, and overall well-being.
United Kingdom - recruitingNA
Nitrous Oxide and EMOtional Cognition
This study investigates how nitrous oxide (like 'laughing gas') affects how healthy people aged 18-40 remember difficult memories and process emotions. Researchers hope to understand if it could help with depression by altering emotional responses.
United Kingdom - recruiting
Who Fares Best With Mindfulness Meditation
This study looks at how mindfulness meditation affects different people. It aims to find out who benefits most and who might experience problems. Researchers want to understand why mindfulness works for some and not for others, especially those with past trauma or negative thinking.
Belgium · United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A randomized, double-blind, single-center, 2-period cross-over Phase I study to assess the tolerability, safety and pharmacokinetics of antidepressant doses of oral ketamine hydrochloride prolonged release tablets (KET01) compared to intranasal esketamine in healthy male subjects
This study is looking at a new tablet treatment for depression called KET01, comparing it to an existing nasal spray called Spravato. It's an early study to see if KET01 is safe, how the body handles it, and if it causes any unwanted effects in healthy men.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase I, first-in-man, randomised, placebo-controlled, single dose escalation study to investigate the effects of LPH-5 on safety, tolerability, pharmacokinetic and pharmacodynamic parameters in healthy participants
This study is looking at a new medicine called LPH-5 for depression. It's the first time we're testing it in people to see if it's safe, how much the body absorbs, and what it does. Healthy adults will be involved.
France - ongoing, recruitingTherapeutic exploratory (Phase II)
Effect of psilocybin on the positive valence system in treatment-resistant depression: a pilot clinical neuroimaging study
This study looks at how a special substance called psilocybin might affect the brain in people with severe depression that hasn't responded to other treatments. Researchers are using brain scans to see changes and checking if it helps improve mood.
France - authorisedTherapeutic exploratory (Phase II)
OSU6162 as add-on in SSRI/SNRI-resistant depression (ODEN): a double-blind, placebo-controlled evaluation of efficacy and safety
This study is looking into a new treatment called OSU6162 for people with depression that hasn't improved with usual medications like SSRIs or SNRIs. It compares OSU6162 to a dummy pill (placebo) to see if it helps reduce depression symptoms and if it's safe.
Sweden - authorisedHuman Pharmacology (Phase I)- Other
Unraveling the aesthetic mind in anhedonia, insights from pharmacological imaging of the human brain: A single-blind, randomized, placebo-controlled cross-over study
This study looks at how people with depression experience beauty and art, and how a new treatment might affect these feelings. It’s a very early-stage trial, comparing the treatment to a dummy pill in adults.
Austria - recruitingNA
The Taste-Mood Diagnostic Study
This study is investigating if a simple taste test can help diagnose depression and predict how well antidepressants might work. Participants will do taste tests before and after starting a new antidepressant for their depression.
United Kingdom - recruitingNA
Mechanisms Underlying Antidepressant Effects of Physical Activity
This study looks at how exercise helps people with depression. We want to understand what goes on in the body and brain when people exercise, to make exercise plans even better. Participants will do either aerobic exercise or stretching for 8 weeks.
United Kingdom - recruiting
Visual Frailty in Ageing
This study looks at 'visual frailty' in older people with a common eye condition called AMD. Researchers want to understand and measure how vision problems, general health, and mental well-being are linked, to help improve care for ageing eyes.
United Kingdom - recruiting
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
This study, called VESPAR, looks at how blood flow in the brain affects thinking problems like dementia, depression, and stroke. Researchers want to find better ways to measure brain blood flow and understand how it changes in different conditions to help plan future research.
United Kingdom - recruitingNA
The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms
This study looks at whether high doses of Vitamin B6 can help reduce feelings of anxiety and depression. Researchers want to see if it changes brain activity and improves symptoms in people aged 18-41.
United Kingdom - recruitingNA
Effectiveness of CAT-GSH for Returning Patients
This study looks at two types of guided self-help therapy for people who have had anxiety or low mood before and are returning to NHS Talking Therapies. It compares CAT-GSH with CBT-GSH to see which works best and is preferred for those coming back for more support.
United Kingdom - not yet recruitingNA
StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression
This study looks at whether an AI tool called ‘StratCare’ can help people with depression get the right treatment faster in the NHS. It compares this new approach to the usual way of offering therapy.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
PRECISER; Prediction of ECT treatment response and reduction of Cognitive Side-effects using EEG and Rivastigmine
This study looks at ways to improve depression treatment using ECT (electroconvulsive therapy). Researchers are testing a medication called rivastigmine to see if it can help reduce memory problems from ECT and predict who will respond best to the treatment.
Netherlands - recruitingPHASE3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
This study is looking into a new medication called CYB003 for adults with major depression. It aims to see if CYB003 is safe and effective when added to their current antidepressant treatment, compared to a dummy pill.
United States · Australia · Czechia - recruitingNA
Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work
This study looks at whether an AI avatar called Remi can help employees with depression symptoms. It's an online program offering short, guided sessions. We want to see if it improves mood and work life, and if people find it helpful and safe.
United Kingdom - recruitingNA
Fluoxetine on Emotional Experience (FLEX) Study
This study looks at how a common antidepressant, fluoxetine, affects anger in healthy young people. Researchers will compare fluoxetine to a dummy pill to see if it changes how participants react to anger-related situations and if this shows in their body.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Targeting inflammation in depression using Minocycline: a patient stratification approach using peripheral inflammatory biomarkers and MRI
This study is looking at how a common antibiotic, Minocycline, might help people with depression. Researchers will see if it reduces inflammation in the body and if that helps improve mood. They'll also use brain scans to understand the changes.
Italy - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A randomised, double-blind, placebo-controlled phase Ib trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of ACD856 in healthy participants
This study is testing a new medicine, ACD856, in healthy people. We want to see if it's safe, how well the body handles it, and what it does. This research could help us learn more about treating conditions like depression or Alzheimer's disease.
Sweden - authorisedTherapeutic exploratory (Phase II)
Etude de phase II évaluant la capacité d'un agoniste des récepteurs 5-HT4, le prucalopride (Resolor©), à accélérer l'efficacité thérapeutique d'un antidépresseur de type ISRS: preuve de concept clinique.
This study looks at whether adding a drug called prucalopride to a common antidepressant (escitalopram) can help people with depression feel better faster. Researchers will compare how well people feel over six weeks when taking either prucalopride or a dummy pill alongside their antidepressant.
France - recruiting
Serotonin effects on brain function and their relationship to relapse when stopping antidepressants
This study looks at why depression sometimes comes back when people stop taking antidepressants. Researchers will study brain activity in people who have recovered from depression and plan to stop their medication. The aim is to understand how changes in brain chemicals contribute to relapse.
United Kingdom · England - active not recruitingPHASE1, PHASE2
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
This study is looking at a new drug called ELE-101 for depression. It checks how safe it is and how it works in healthy people first, then in people with depression, to see if it could be a helpful new treatment.
United Kingdom - recruitingNA
7T Amygdala and Citalopram Study
This study looks at how a common antidepressant, citalopram, affects a brain area called the amygdala when people see emotional faces. It aims to understand how this medicine works on different parts of the amygdala.
United Kingdom - recruiting
Evaluating the Role of IL-17 as an Orchestrator of Peripheral-central Cross Talk in Depressive Symptoms
This study investigates how inflammation, particularly involving a protein called IL-17, might link certain skin and joint conditions like psoriasis and psoriatic arthritis with depression. Researchers will use special brain scans and different anti-inflammatory medicines to understand and potentially improve depression symptoms.
United Kingdom - recruitingNot Applicable
Sleep Blinding Psilocybin, a feasibility study: Examining if participants can tell if they received psilocybin or a placebo when medication is given to act in sleep
This study explores a new way to test psilocybin (from 'magic mushrooms') for depression by giving it to people while they sleep. This helps researchers understand how it works without participants knowing if they received the drug or a dummy pill.
United Kingdom · England