Depression - Major Depressive Disorder research hub
15 indexed studies · 13 currently recruiting
- not yet recruitingNA
Dual Neuromodulation for Depression: Boosting TMS With tES
This study is looking at a new way to treat depression by combining two brain stimulation techniques: Transcranial Magnetic Stimulation (TMS) and Transcranial Alternating Current Stimulation (tACS). We want to see if combining them helps TMS work better for people with depression, especially by improving how their brain processes emotions.
United Kingdom - recruitingPHASE3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
This study is looking into a new medication called CYB003 for adults with major depression. It aims to see if CYB003 is safe and effective when added to their current antidepressant treatment, compared to a dummy pill.
United States · Australia · Czechia - not yet recruitingNA
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression
This study aims to understand if depression is linked to a lack of a brain chemical called serotonin. Researchers will use special scans to see how serotonin levels change in people with depression compared to healthy volunteers, hoping to find better ways to treat depression.
United Kingdom - not yet recruitingPHASE1
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
This study looks at a new way to treat depression and extreme tiredness (fatigue) in people with Multiple Sclerosis (MS). It uses magnetic pulses to gently stimulate the brain. Researchers want to see if it's safe and helps improve mood and energy levels.
Canada - recruitingPHASE2
Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression
This study looks at two types of dexamfetamine medication for adults aged 18-65 who have both ADHD and moderate to severe depression. We want to see if these medications are safe and help improve symptoms better than a dummy pill.
Germany - active not recruiting
Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and Anhedonia
This study looks at how a nasal spray called esketamine might help quickly reduce suicidal thoughts in people with severe depression. Researchers want to understand who benefits most and why, by looking at existing data from previous trials.
France - active not recruiting
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin
This study looks at whether psilocybin, a compound from certain mushrooms, can help people with depression that hasn't responded to usual treatments. It focuses on whether psilocybin affects inflammation in the body, as inflammation might play a role in depression.
United Kingdom - recruiting
Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups
This study looks at how mental health and diabetes are linked. Researchers want to find different groups of people with diabetes who share similar mental health challenges, so they can offer more personal and effective support.
Germany - recruiting
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories
This study, called BLOOM, looks at how young people's mental health develops between ages 9 and 25. It aims to understand early signs of mental health conditions like depression and ADHD, to help find ways to support young people before problems become serious.
Canada - not yet recruitingNA
Interest of Adaptated Physical Activity (APA) on the K Recovery Constant, Reflecting the Rate of Muscle Oxygenation Recovery in Menopausal Women Suffering From Depression
This study looks at how adapted physical activity might help menopausal women with depression. Researchers want to see if special exercises can improve how their muscles use oxygen, which could help reduce symptoms of depression. It's a randomised study comparing exercise to another type of support.
France - not yet recruitingNA
PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low Mood
This study looks at how a licensed constipation medicine, prucalopride, affects mood, sleep, and thinking in people with low mood. It aims to understand if boosting a specific brain chemical system (serotonin 4 receptor) could help develop new treatments for depression.
United Kingdom - enrolling by invitation
Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screening Using PHQ-9
This study is testing a new voice chatbot that uses advanced AI to screen for depression. It asks you questions about your mood and feelings and then gives you tailored advice. The aim is to see if this chatbot can help people check their mental health easily and accurately.
United Kingdom - not yet recruiting
Mental Health Mission Mood Disorder Cohort Study
This study aims to understand why some people with depression respond to treatment better than others. It looks at various factors like symptoms, genes, and body chemistry to find new ways to improve diagnosis and treatment for mood disorders.
United Kingdom - recruiting
Investigating the Impacts of Early Life Experience on the Brain & Behaviour
This study explores how early life experiences can affect your brain, behaviour, and immune system as an adult. We want to understand why some early experiences lead to mental health challenges later on, helping us identify and support young people who might need help in the future.
United Kingdom - recruitingNA
Fluoxetine on Emotional Experience (FLEX) Study
This study looks at how a common antidepressant, fluoxetine, affects anger in healthy young people. Researchers will compare fluoxetine to a dummy pill to see if it changes how participants react to anger-related situations and if this shows in their body.
United Kingdom