- recruitingPHASE4
Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
This study looks at a medicine called nirogacestat for women with desmoid tumours. It aims to understand how the medicine affects their ovaries and if it helps treat their tumour, while also checking for any side effects.
Belgium · Germany · Italy - recruitingNA
Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting
This study looks at two ways to treat desmoid tumours that grow after a 'wait and see' period: freezing them (cryoablation) or using medicine. It wants to see which works better for patients aged 13 and up.
France - active not recruitingPHASE2, PHASE3
A Study of AL102 in Patients With Progressing Desmoid Tumors
This study is looking at a new medication, AL102, for people with desmoid tumours that are growing. It aims to see how well it works and if it's safe, comparing it to a dummy treatment (placebo) in some parts of the study.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 Study to Determine the Effect of CYP Induction Following Administration of Nirogacestat in Healthy Men Participants
This early-stage study is looking at how a new medicine called Nirogacestat works in healthy men. It's not for people with desmoid tumours yet, but aims to understand how the body handles the medicine to help future research for this condition.
Netherlands