- recruiting
Parallel transmit for 7T MRI imaging in epilepsy
This UK study tests a powerful new brain scan called a 7T MRI for adults with focal epilepsy. Standard scans often miss the tiny brain areas causing seizures. Researchers are testing special scanning techniques to get clearer pictures, helping doctors decide if brain surgery could safely stop a patient's seizures.
United Kingdom · England - recruitingNot Applicable
An early feasibility study evaluating a novel device for identifying seizure activity in a sample of 15 children
This study tests a new wireless brain monitor called Clic EEG in children with epilepsy. Doctors at Bristol Children's Hospital want to see if this wearable sensor detects seizures as well as standard hospital equipment. The goal is to make epilepsy testing faster, easier, and more comfortable for young people.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Open-Label Study to Investigate the TARP-ɣ8 Receptor Occupancy of RAP-219 Using a TARP-γ8 PET Tracer in Healthy Adult Participants
This study is looking at a new medicine called RAP-219. It's a very early-stage trial in healthy adults to see how the medicine works in the body, specifically how it attaches to a certain target in the brain, which might help with conditions like epilepsy. This helps researchers understand if it could be a good treatment.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
Evaluation of safety and pharmacokinetic parameters of the PTI5803 product
This study is testing a new medicine, PTI5803, for epilepsy. It's a very early stage trial to check if the medicine is safe and how it moves through the body in healthy adults. This helps scientists understand if it could be a good treatment for epilepsy in the future.
France - recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Open-Label, Multiple-Part Trial to Evaluate the Drug-Drug Interaction Potential of PRAX-628 in Healthy Participants
This study is looking at a new medicine called PRAX-628 for epilepsy. It's a very early-stage trial in healthy volunteers to see how this new medicine interacts with other common medications. We want to make sure it's safe to take with other drugs.
Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Brivaracetam Tablets Ph. Eur. 100 mg, manufactured by Sun Pharmaceutical Industries Limited, India with Briviact (brivaracetam) 100 mg film-coated tablets, Marketing Authorisation Holder: UCB Pharma S.A., Allée de la Recherche 60, B-1070 Bruxelles, Belgium; Manufactured by UCB Pharma S.A., Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium, in healthy adult, human subjects under fasting condition.
This study compares a new epilepsy drug (Brivaracetam) from Sun Pharma with an existing one (Briviact) to see if they work the same way in the body. It involves healthy adults taking both drugs to check their similarity.
Romania - recruiting
Optimizing epilepsy surgery
This study looks at ways to make brain surgery for epilepsy safer and more effective. By using advanced 3D brain scans and computer tools, surgeons aim to pinpoint and remove the exact areas causing seizures, while protecting healthy tissue that controls memory, speech, and eyesight.
United Kingdom · England - recruitingNot Applicable
Vagus nerve stimulation for epilepsy in children and adults: assessment of longer term clinical and cost effectiveness in a randomised controlled trial
This study looks at how well a treatment called Vagus Nerve Stimulation (VNS) works for children and adults with epilepsy that hasn't responded to other medicines. We want to understand its long-term benefits and if it helps people with learning difficulties.
United Kingdom · England · Scotland - recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Open-Label, Follow-Up Study to Assess the Long-Term Use of Oral Lacosamide in Study Participants Who Completed EP0034 or SP848 and Received Lacosamide Treatment
This study is looking at the long-term safety and how well a medicine called lacosamide works for people with epilepsy. It's for those who have already taken lacosamide in previous studies and want to continue their treatment.
Hungary · Romania - recruitingHuman Pharmacology (Phase I)- Other
A phase I, randomized, double-blind, placebo-controlled, two-way cross-over, multiple dose study to evaluate the pharmacodynamic effects of TRV045 on the cortical excitability in healthy male adults
This early-stage study looks at a new drug called TRV045 for epilepsy. It's testing how the drug affects brain activity in healthy men to see if it could be a useful treatment in the future. Participants will receive either the drug or a dummy pill.
Netherlands - recruitingTherapeutic exploratory (Phase II)
A Randomized Phase 2 Study of Adjunctive EQU-001 for Uncontrolled Focal Onset Seizures
This study is testing a new medicine, EQU-001, for people with epilepsy whose seizures aren't fully controlled by their current treatment. It aims to see if the new medicine can reduce the number of seizures compared to a dummy medicine.
Sweden · Italy · France - active not recruitingNA
AI-enhanced LF-MRI in Epilepsy
This study is looking at a new, more affordable MRI scan for people with epilepsy. It uses a lower-strength MRI machine and artificial intelligence to see if it can diagnose epilepsy as well as the standard, more expensive scans. We want to help more people get the right diagnosis, especially in areas where advanced scans are hard to find.
United Kingdom - recruiting
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This study looks at how medical cannabis helps people in the UK with pain, sleep problems, anxiety, depression, or epilepsy. We want to see how well it works over time using patient feedback.
Canada - recruiting
Seizure Recurrence After Unprovoked First Seizure
This study aims to understand why some people have another seizure after their first one. Researchers will use special brain scans and tests to predict who is most likely to have more seizures, helping doctors decide if treatment is needed sooner.
Canada - recruitingPHASE3
Lemborexant Treatment of Insomnia Linked to Epilepsy
This study is looking at a new medication, Lemborexant, to see if it can help people with epilepsy sleep better. Researchers want to know if it improves sleep without causing problems, compared to a dummy pill.
United States · Canada - recruitingNA
Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
This study looks at new ways to find the source of epilepsy in people whose seizures don't respond to medication. It compares standard brain recordings with a newer method using special electrodes to see if it helps doctors plan better surgery to stop seizures.
France - active not recruiting
Electrical Impedance Tomography of Epilepsy
This study is looking at a new, safe imaging method called Electrical Impedance Tomography (EIT) for people with epilepsy. It aims to see if EIT can show accurate images of brain activity during seizures, similar to existing scans like MRI, but in a simpler way.
United Kingdom - recruiting
SCN1A Horizons A Natural History Study of SCN1A-related Epilepsies in the United Kingdom
This study looks at how Dravet Syndrome and other epilepsy linked to the SCN1A gene affect people over three years. Researchers want to understand seizures, development, and behaviour, and how different gene changes might lead to different experiences.
United Kingdom - recruiting
Identification of Volatile Organic Compounds (VOCs) as Biopredictors of Epileptic Seizures
This study looks for smells linked to epileptic seizures. We know some dogs can sniff out seizures. Researchers hope to find these unique smells, called 'volatile organic compounds,' to create a device that can predict seizures before they happen, helping people with epilepsy live better lives.
France - recruiting
Neuropsychiatric Research Databases for People With Intellectual Disabilities and Epilepsy (REFINE)
This study aims to build a research database and register for people in the UK with intellectual disabilities and epilepsy. It will help researchers understand these conditions better and find people who might want to join future studies, with all personal details kept private where possible.
United Kingdom - not yet recruitingNA
Compassion Focussed Therapy Informed Psychoeducation and Loving Kindness Meditation for Young People With Epilepsy
This study looks at a new way to help young people with epilepsy feel better mentally. It explores if special talking sessions and calming meditation can help reduce stress and improve their feelings about themselves, as living with epilepsy can sometimes make people feel down.
United Kingdom - recruiting
Epilepsy and Driving
This study looks into how epilepsy might affect driving. It aims to find better ways to check if people with epilepsy are safe to drive, using tools like driving simulators and brain scans (EEGs). The goal is to help people with epilepsy keep their independence safely.
France - recruiting
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome
This study looks at how a diabetes medicine, sulphonylurea, affects brain development in children and adults with a specific genetic condition called iDEND syndrome. We want to see if starting this medicine early in life leads to better developmental outcomes.
United States · Italy · Norway - recruiting
Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents
This study looks at how children and teenagers with rare types of epilepsy respond to treatments and how their learning and behaviour change over time. It aims to gather real-life information to help doctors better understand and manage these conditions, as there isn't much information available right now.
France - not yet recruiting
S100B Protein: a Diagnostic Aid in Episodes of Transient Loss of Consciousness?
Doctors are studying a blood test to help quickly figure out why someone fainted or passed out. They want to see if measuring a protein called S100B can help tell the difference between epileptic seizures and other causes, making diagnosis faster and potentially reducing hospital stays.
France - recruitingNA
Cartography of Social Cognition Network and Their Alterations in Patients With Epilepsy
This study looks at how epilepsy affects social skills, like understanding people's feelings. We're using special MRI scans to map brain networks in people with epilepsy before and after surgery, and in healthy volunteers, to understand these changes better.
France - recruitingNA
The Clinical Utility of BioEP in Diagnostic Decision Making in Epilepsy
This study looks at how a new tool called BioEP helps doctors diagnose epilepsy after a first seizure. It compares usual care with usual care plus BioEP to see if it makes diagnosis clearer and faster for adult patients.
United Kingdom - active not recruiting
Ultra-long-term EEG Monitoring in PwID
This study is testing a tiny device placed under the skin to track brain activity in people with intellectual disabilities who have seizures. It aims to see how well it works, if it's safe, and how it affects their daily lives, as well as the experiences of carers and doctors.
United Kingdom - recruiting
An Observational Study of Epilepsy: Biology and Outcomes Using Real-world Data
This study aims to understand epilepsy better by looking at health records and blood samples from people in South Wales. We want to find out why epilepsy affects people differently and how it progresses over time, without changing their usual care.
United Kingdom - recruiting
Volatile Non-Invasive Biomarkers of Epileptic Seizures
This study looks for tiny molecules in breath and sweat after someone has a suspected seizure. The aim is to find a unique pattern that can help doctors tell the difference between epileptic seizures and other events, and potentially understand how severe a seizure was.
United Kingdom - recruitingNA
Electrical Impedance Tomography & Selective Stimulation of Vagus Nerve
This study is looking at new ways to stimulate a nerve called the vagus nerve more precisely during standard epilepsy surgery. The goal is to better understand how this nerve works in humans to treat conditions like epilepsy more effectively, while reducing unwanted side effects.
United Kingdom - recruitingNA
Mos-FED (Mosaicism in Focal Epilepsy Cortical Dysplasia Tissue)
This study looks into why some children and adults with a brain condition called Focal Cortical Dysplasia (FCD) get severe epilepsy. By studying brain tissue, blood, and nasal samples, researchers hope to find new causes and develop better ways to detect and treat this type of epilepsy.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - active not recruitingNA
Music as an Adjunctive Epileptic Seizure Treatment Option
This study is looking at whether listening to a specific piece of Mozart music (K448) can help children aged 2-16 with epilepsy that hasn't responded well to medicines. It aims to see if the music can reduce seizures and improve thinking skills, and help plan bigger studies in the future.
United Kingdom