Fibrostenotic Crohn’s disease research hub
7 indexed studies · 4 currently recruiting
- recruitingHuman Pharmacology (Phase I)- Other
A study to Learn How Safe AGMB-129 is in Healthy Adults Taking Multiple Doses of AGMB-129 That Are Increased a Little at a Time
This study is looking into a new medication called AGMB-129 for Crohn's disease. It's a very early-stage trial checking if the medication is safe for healthy adults when given in small, increasing doses.
Belgium - completedPhase I
Human mass balance study of [14C]ontunisertib in healthy volunteers
Researchers are studying an experimental medicine called ontunisertib, being developed for Crohn's disease. This early-stage study in healthy men looks at how the body absorbs, breaks down, and removes the medicine. Volunteers stay in a specialist clinic for up to 10 days and provide blood, urine, and stool samples.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- Other
An Open-Label, Fixed-Sequence, Drug-Drug Interaction Study in Healthy Participants to Evaluate the Effect of AGMB-129 on the Pharmacokinetics of Midazolam, a Sensitive Index Substrate of CYP3A4
This study is looking at how a new medicine, AGMB-129, interacts with another common medicine called midazolam in healthy volunteers. The goal is to understand how their bodies process these medicines when taken together.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
Relative Bioavailability and Effect of Food Study With AGMB-129 in Healthy Participants
This study is testing a new medicine, AGMB-129, for Crohn's disease. Researchers want to see how well the body absorbs the medicine and if food affects it. It's a very early study in healthy people to understand the medicine better before trying it in patients.
Belgium - active not recruitingPHASE1
A Study of PALI-2108 in Healthy Volunteers, Patients With Ulcerative Colitis, and Patients With Fibrostenosing Crohn's Disease
This study looks at a new drug, PALI-2108, for people with a type of Crohn's disease that causes narrowing (fibrostenotic Crohn's). We want to understand how it works in the body to help with inflammation and scarring.
Canada - active not recruitingPHASE2
STENOVA - A Study to Evaluate Safety, Tolerability, PK and PD of AGMB-129 in Patients With Fibrostenotic Crohn's Disease
This study looks at a new drug, AGMB-129, for people with Crohn's disease who have narrowing in their bowel. It aims to see if the drug is safe, how the body handles it, and if it can help improve these narrowed areas.
United States · Austria · Canada - recruitingPHASE1
Human Mass Balance Study of [14C] Ontunisertib in Healthy Volunteers
This study in healthy men aged 30-65 is looking at a new medicine called Ontunisertib, which might help people with a gut condition called Crohn's disease. Researchers want to understand how the body takes in, uses, and gets rid of this medicine, including how quickly and through what routes it leaves the body.
United Kingdom