Functional hypogonadism research hub

SEMAGONA: A randomized four-arm parallel group double-blind double dummy 52-week clinical trial comparing the effects of s.c. Semaglutide 2.4 mg once-weekly, i.m. testosterone undecanoate 1,000 mg every 13th week, combination of s.c. Semaglutide 2.4 mg once-weekly and i.m. testosterone undecanoate 1,000 mg every 13th week, and placebo on body composition and hypogonadal symptoms in men with obesity-associated functional hypogonadism

This study tests whether combining a weekly weight-loss injection (semaglutide) with testosterone injections helps men with low testosterone linked to obesity. Researchers want to see if using both medicines together improves muscle mass, reduces body fat, and relieves symptoms better than using either treatment alone or a dummy drug.