- recruiting
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
This study aims to understand Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) better. Researchers are looking for genetic links to these conditions to learn more about how they develop. It includes people with a diagnosis of GCA or PMR, aged 50 or over.
United Kingdom - active not recruiting
PET Imaging of Giant Cell and Takayasu Arteritis
This study is looking for better ways to spot and track types of blood vessel inflammation called Giant Cell Arteritis and Takayasu Arteritis. We're using new scanning methods called PET-MRI to see if they can show inflammation more clearly than current tests, especially after treatment.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy of Methotrexate as Remission Maintenance Therapy after Remission-Induction Therapy with Tocilizumab and Glucocorticoids in Subjects with Giant Cell Arteritis
This study looks at whether a medicine called methotrexate can help people with giant cell arteritis stay well after their first treatment. It compares methotrexate to a dummy treatment (placebo) to see if it stops the illness from coming back.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Giant Cell Arteritis
This study is testing a new medicine, upadacitinib, for giant cell arteritis (GCA). Researchers want to see if it can help people stay well and reduce the need for steroid medicines, comparing it to a dummy medicine.
Denmark · Belgium · Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, parallel-group, double-blind, placebo-controlled, multicenter trial to investigate the efficacy and safety of subcutaneously administered secukinumab in patients with new-onset of giant cell arteritis (GCA) who are in clinical remission and eligible for treatment with glucocorticoidmonotherapy (GigAINt)
This study is testing a new medicine, Cosentyx, for people with Giant Cell Arteritis (GCA) who are already feeling better. We want to see if it can help stop GCA from coming back and allow people to take less steroid medicine, compared to a dummy drug.
Germany - authorisedTherapeutic confirmatory (Phase III)
A Randomized Double-Blind, Placebo Controlled Trial of Abatacept (CTLA4-Ig) in Giant Cell Arteritis (ABAGART)
This study is looking into a new medicine called abatacept for a condition called Giant Cell Arteritis (GCA). We want to see if abatacept can help people stay well without symptoms compared to a dummy medicine, focusing on how patients feel and their safety over 12 months.
Italy · Germany