Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) research hub
16 indexed studies · 9 currently recruiting
- recruiting
One-Time DNA Study for Vasculitis
This study aims to understand why some people get vasculitis, a group of conditions causing inflamed blood vessels. Researchers will look at DNA to find genes that increase the risk, hoping to improve diagnosis and treatments for different types of vasculitis.
United States · Canada · Turkey (Türkiye) - recruiting
VCRC Tissue Repository
This study collects leftover tissue samples from people already part of other vasculitis research. These samples help scientists understand different types of vasculitis better, aiming to find new ways to test for and treat these conditions.
United States · Canada - recruiting
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
This study aims to better understand, diagnose, and manage Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR). Researchers are looking at various body markers and using advanced imaging to improve how these conditions are found and treated.
Germany - recruiting
Impact of the Spatial Resolution of Several Contrast-enhanced 3D T1-WI Sequences When Diagnosing Giant Cell Arteritis (GCA)
This study is looking into better ways to diagnose Giant Cell Arteritis (GCA), a condition causing inflammation in blood vessels. Researchers are testing different types of MRI scans to see which ones are best at spotting GCA, especially in local hospitals. The goal is to make it easier to diagnose GCA quickly and accurately, which is very important for treatment.
France - recruiting
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
This study aims to understand Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) better. Researchers are looking for genetic links to these conditions to learn more about how they develop. It includes people with a diagnosis of GCA or PMR, aged 50 or over.
United Kingdom - active not recruitingPHASE3
MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter, Randomized, Controlled Trial
This study compares two treatments, methotrexate and tocilizumab, for Giant Cell Arteritis (GCA). GCA causes inflammation in blood vessels, often affecting older adults. The aim is to find out if methotrexate is as effective as tocilizumab in preventing GCA flare-ups, but potentially with fewer side effects and lower cost.
France - recruiting
Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients With Giant Cell Arteritis
This study looks at whether changes in blood vessels seen on ultrasound scans of people with Giant Cell Arteritis (GCA) can predict if their condition will flare up. It uses routine check-ups to understand how GCA develops over time.
France - recruitingPHASE3
Abatacept for the Treatment of Giant Cell Arteritis
This study is looking into a new treatment called abatacept for a condition called Giant Cell Arteritis (GCA). We want to see if abatacept can help people with newly diagnosed or returning GCA stay well. The treatment is given by injection, and some people will get a dummy treatment instead.
United States · Canada - active not recruiting
PET Imaging of Giant Cell and Takayasu Arteritis
This study is looking for better ways to spot and track types of blood vessel inflammation called Giant Cell Arteritis and Takayasu Arteritis. We're using new scanning methods called PET-MRI to see if they can show inflammation more clearly than current tests, especially after treatment.
United Kingdom - recruiting
Optic Nerve Sheath Ultrasound in Giant Cell Arteritis
This study looks at using a simple ultrasound scan of the eye's nerve to help diagnose and keep an eye on a condition called Giant Cell Arteritis (GCA). We want to see if this scan can spot new GCA and check how patients are doing over time.
Canada - recruiting
Giant Cell Arteritis - Ways to Precision Medicine
This study looks at people with Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) over many years. It aims to understand how their illness affects blood vessels like the aorta, side effects from common medications, and how we might offer more personalised treatments for these conditions.
Germany - active not recruiting
The Applanation Tonometry in GCA Pilot
This study, called ATOM-GCA, looks at how a special type of measurement from the blood vessels in your temples can help doctors diagnose a condition called Giant Cell Arteritis (GCA). It also checks how easy it is for people to have these measurements taken repeatedly.
Canada - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Giant Cell Arteritis
This study is testing a new medicine, upadacitinib, for giant cell arteritis (GCA). Researchers want to see if it can help people stay well and reduce the need for steroid medicines, comparing it to a dummy medicine.
Denmark · Belgium · Germany - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy of Methotrexate as Remission Maintenance Therapy after Remission-Induction Therapy with Tocilizumab and Glucocorticoids in Subjects with Giant Cell Arteritis
This study looks at whether a medicine called methotrexate can help people with giant cell arteritis stay well after their first treatment. It compares methotrexate to a dummy treatment (placebo) to see if it stops the illness from coming back.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, parallel-group, double-blind, placebo-controlled, multicenter trial to investigate the efficacy and safety of subcutaneously administered secukinumab in patients with new-onset of giant cell arteritis (GCA) who are in clinical remission and eligible for treatment with glucocorticoidmonotherapy (GigAINt)
This study is testing a new medicine, Cosentyx, for people with Giant Cell Arteritis (GCA) who are already feeling better. We want to see if it can help stop GCA from coming back and allow people to take less steroid medicine, compared to a dummy drug.
Germany - authorisedTherapeutic confirmatory (Phase III)
A Randomized Double-Blind, Placebo Controlled Trial of Abatacept (CTLA4-Ig) in Giant Cell Arteritis (ABAGART)
This study is looking into a new medicine called abatacept for a condition called Giant Cell Arteritis (GCA). We want to see if abatacept can help people stay well without symptoms compared to a dummy medicine, focusing on how patients feel and their safety over 12 months.
Italy · Germany