Large Vessel Vasculitis research hub

Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study.

This study aims to improve how we diagnose and monitor a condition called Large Vessel Vasculitis (LVV) using a new type of body scan. The goal is to make these scans clearer, faster, and potentially lead to better, more personalised treatment plans for patients with LVV.

Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA)

This study looks at a serious blood vessel condition called Giant Cell Arteritis (GCA). We're using a special scan to see tiny immune cells, called B cells, in the blood vessels. We want to find out if targeting B cells with new treatments could help people with GCA, reducing the need for strong steroid medications.

Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)

This study looks at how two medicines, Bosentan and dapagliflozin, might help people with a condition called Large Vessel Vasculitis (LVV). LVV damages blood vessels, increasing risks like heart attacks. We want to see if these medicines can improve blood vessel health.

Study to evaluate the pharmacokinetics, safety and tolerability of Secukinumab in patients with GCA or PMR

A randomized, parallel-group, double-blind, placebo-controlled, multicenter Phase III trial to investigate the efficacy and safety of secukinumab 300 mg and 150 mg administered subcutaneously versus placebo, in combination with a glucocorticoid taper regimen, in patients with giant cell arteritis (GCA) (GCAptAIN)