- recruiting
Targeted Pediatric High-Grade Glioma Therapy
This study aims to understand childhood brain tumours better by looking at their genes. For children, teenagers, and young adults with newly diagnosed high-grade gliomas, including DIPG, doctors will check their tumour's genetic makeup to see if they might be suitable for specific new treatments in future trials.
United States · Australia · Canada - recruitingPHASE2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
This study is looking at new drug combinations to treat certain types of brain tumours in children and young adults. It aims to see if combining ribociclib with either everolimus or temozolomide can help patients live longer and improve their health.
United States · Australia · Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 0 lead-in trial of Pitavastatin in primary and recurrent Glioblastoma patients
This early-stage study is looking into a drug called Pitavastatin for people with a type of brain tumour called Glioblastoma, both new and returning cases. It's an early look to see how the drug works in the body.
Netherlands - recruitingPHASE1
First-in-human Trial of PhOx430, a First-in-class Acetylglucosaminyltransferase V Inhibitor, in Advanced Solid Tumours
This study tests an investigational drug called PhOx430 for advanced cancers that haven't responded to other treatments. It aims to find a safe dose and see how well it works, especially in certain types of solid tumours.
France · Italy - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - recruiting
The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
This study looks at the best way to care for people with a serious type of brain tumour called high-grade glioma. It compares palliative care, a small operation (biopsy), or a larger operation (resection) to see which approach offers the best quality of life and survival.
United States · Belgium · Germany - active not recruitingPHASE1
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
This study is testing a new cancer vaccine called SurVaxM for children and young adults with specific types of brain tumours. It aims to train the body's immune system to find and destroy cancer cells that have a special protein.
United States · Canada - recruitingPHASE2
Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma
This study is for adults with glioblastoma, a type of brain cancer, that has returned after initial treatment. It compares two different drug combinations, delivered directly into the brain's blood vessels, to see which works best at slowing the cancer's growth.
Canada - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A clinical gene therapy study with hematopoietic stem cells for the treatment of patients suffering from a malignant neoplasm of the central nervous system
This study is looking at a new gene therapy for a serious type of brain tumour called glioblastoma. It's the first time this treatment is being used in people, aiming to see if it's safe and how well it works to fight the cancer.
Italy - recruiting
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
This study compares two ways to treat serious brain tumours (high-grade gliomas) in older patients or those who are not very active: having surgery to remove the tumour (resection) or taking a small tissue sample (biopsy). It looks at survival, quality of life, and if patients can then have other treatments.
United States · Belgium · Germany - active not recruitingPHASE2
Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM
This study is looking at adding an existing diabetes drug, Metformin, to the usual treatment for a type of aggressive brain cancer called Glioblastoma (GBM). Researchers hope Metformin will make the standard treatments work better and help people live longer.
Canada - active not recruitingPHASE1, PHASE2
A Trial of Ipatasertib in Combination With Atezolizumab
This study looks at combining two medicines, ipatasertib and atezolizumab, for advanced solid tumours and a type of brain tumour called glioblastoma. It aims to find the safest dose and see how well they work together. It's a early-stage study to understand more about these treatments.
United Kingdom - authorisedTherapeutic use (Phase IV)
An open label, Phase IV study to assess immunological changes in patients with glioblastoma multiforme treated with bevacizumab infusion
This study is looking at how a treatment called bevacizumab (also known as Avastin) affects the body's defence system in people with a type of brain tumour called glioblastoma multiforme. The aim is to understand more about the disease and how well patients respond to treatment.
Hungary - active not recruitingPHASE2, PHASE3
LAM561 With RT and TMZ for Adults With Glioblastoma
This study is testing a new drug, LAM561, for newly diagnosed glioblastoma (a type of brain cancer). It compares LAM561 to a dummy pill, both given with standard treatments (radiotherapy and chemotherapy), to see if it improves survival and slows cancer growth.
France · Israel · Italy - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom