- active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - active not recruitingPHASE1, PHASE2
A Trial of Ipatasertib in Combination With Atezolizumab
This study looks at combining two medicines, ipatasertib and atezolizumab, for advanced solid tumours and a type of brain tumour called glioblastoma. It aims to find the safest dose and see how well they work together. It's a early-stage study to understand more about these treatments.
United Kingdom - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - recruitingPHASE2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
This study is looking at new drug combinations to treat certain types of brain tumours in children and young adults. It aims to see if combining ribociclib with either everolimus or temozolomide can help patients live longer and improve their health.
United States · Australia · Canada - active not recruitingPHASE2, PHASE3
LAM561 With RT and TMZ for Adults With Glioblastoma
This study is testing a new drug, LAM561, for newly diagnosed glioblastoma (a type of brain cancer). It compares LAM561 to a dummy pill, both given with standard treatments (radiotherapy and chemotherapy), to see if it improves survival and slows cancer growth.
France · Israel · Italy - recruiting
Targeted Pediatric High-Grade Glioma Therapy
This study aims to understand childhood brain tumours better by looking at their genes. For children, teenagers, and young adults with newly diagnosed high-grade gliomas, including DIPG, doctors will check their tumour's genetic makeup to see if they might be suitable for specific new treatments in future trials.
United States · Australia · Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 0 lead-in trial of Pitavastatin in primary and recurrent Glioblastoma patients
Netherlands - authorisedTherapeutic use (Phase IV)
An open label, Phase IV study to assess immunological changes in patients with glioblastoma multiforme treated with bevacizumab infusion
Hungary