- recruitingHuman Pharmacology (Phase I)- First administration to humans
A first-in-human, randomized, participant and investigator blinded, placebo-controlled single and multiple ascending dose study to assess the safety, tolerability and pharmacokinetics of HJB647 in healthy participants and otherwise healthy participants with elevated blood pressure, with an open-label CYP3A inhibitor drug-drug interaction part
This early-stage study is testing a new medicine called HJB647 for the first time in people. We want to see if it's safe and how the body handles it. Some people in the study will have slightly high blood pressure, and we're also checking how HJB647 works with another common medicine.
Netherlands - recruiting
Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
This study is testing new ultrasound methods to better understand heart failure in people with atrial fibrillation. It aims to improve how doctors measure pressure in the heart, leading to better diagnosis and treatment, and help predict who might be at higher risk.
United States · Belgium · France - not yet recruiting
Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care
This study looks for undiagnosed heart failure in people with leg swelling (lymphoedema). It uses a quick test at the clinic to find heart problems early, aiming to prevent serious complications and improve care without extra trips to the GP.
United Kingdom - recruitingNA
Early Detection and IntervenTion in Heart Failure
This study aims to find out if spotting and treating heart failure early can reduce hospital stays. Researchers will raise awareness, use a simple blood test, and start treatment quickly for people at risk, then check hospital admissions over 18 months.
Austria · Bulgaria · Germany