Heart Failure With Reduced Ejection Fraction research hub

VITAL - the Heart Failure With Reduced Ejection Fraction Sub-study

This study looks at how we can better predict who will benefit from a heart device called a CRT. It uses special computer models, like a 'digital twin' of your heart, to help doctors decide if the device is right for you, avoiding unnecessary procedures.

Improving CRT Outcome With Non-Invasive Cardiac Mapping

This study looks at a new way to place a special device (CRT) for people with heart failure. It compares standard placement with a new method using a special mapping system to see if it improves how well the treatment works.

The Sarcopenia Study

This study looks at muscle weakness, called sarcopenia, in people with heart failure. Researchers want to see if different types of heart failure affect how common sarcopenia is, comparing heart failure patients to healthy people and those with type 2 diabetes.

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.

Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF

This study tests a new pacemaker designed to restore a natural heart rhythm called Respiratory Sinus Arrhythmia (RSA) in heart failure patients after bypass surgery. Researchers want to know if it's safe and improves heart function compared to standard treatment.

Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope

This study is testing a new AI-powered stethoscope to see if it can help doctors in local clinics find heart problems like heart failure earlier. The aim is to improve heart health and reduce emergency hospital visits for these conditions.

The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.

This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.

Pulmonary REsistance modification under treatment with Sacubitil/valsartaN in paTients with HeartFailure with reduced ejection fraction

This study looks at how a drug called Entresto affects blood pressure in the lungs and how easily blood flows through them, in people with a type of heart failure where the heart struggles to pump blood.

Initiation of angiotensin receptor-neprilysin inhibitor (ARNi) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with heart failure with reduced ejection fraction (HFrEF): the INITIATE-HFrEF randomized open-label trial

A Phase 1b, Double-blind, Placebo-controlled, Randomised Trial Investigating the Effect of AZD3427 on Renal Perfusion in HFrEF Patients With Renal Impairment Using Positron Emission Tomography (PET)