- active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - recruitingPHASE1
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
This study is testing a new drug, zanzalintinib, alone and with other medicines, for people with advanced cancers like kidney, prostate, and lung cancer. It's looking at safety and if the treatment shrinks tumours.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)
This study is looking at a new medicine called Pumitamig, by itself or with another medicine called Ipilimumab. It's for people in the UK with advanced liver cancer that can't be removed by surgery. The main goal is to see how safe and well these treatments are tolerated.
United States · Australia · Chile - recruitingNA
The Dragon PLC Trial (DRAGON-PLC)
This study looks at a new way to prepare people with certain liver cancers for surgery. It compares a standard procedure (PVE) with a new one (PVE + HVE) to see if more people can have life-saving surgery and live longer.
United States · Australia · Austria - recruiting
A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions
This study is testing a simple breath-test to find liver cancer earlier and check on other liver conditions. It looks for tiny chemicals in your breath. You could join if you have liver cancer, cirrhosis, or certain other liver issues, or tummy problems with a normal liver scan.
United Kingdom - not yet recruiting
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
This study is developing a simple breath test to help find common gut cancers earlier, like those in the food pipe, stomach, pancreas, liver, and bowel. Finding cancer early means better treatment options. We're testing if breathing into a special device can quickly spot these cancers by detecting tiny molecules in your breath.
United Kingdom - recruiting
Liver Cancer Registry Platform
This project is setting up a registry in Germany for people with liver cancers like HCC and cholangiocarcinoma. It will collect information on their health, treatments, and how they're feeling, to help doctors understand the diseases better and improve care in the future.
Germany - not yet recruiting
Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance
This study looks at how new imaging technology helps treat cancers in the liver, lung, and bone. It collects information from patients already receiving these treatments to see if the advanced scans can improve planning and results in the future.
France · Netherlands - recruiting
mSEPT9 Biomarker for Predicting Hepatocellular Carcinoma Occurrence in Patients With Cirrhosis
This study looks at a new blood test called mSEPT9 to predict liver cancer (HCC) in people with cirrhosis. We're hoping it can help doctors find liver cancer earlier and tailor treatment plans better for each person.
France - recruitingPHASE1, PHASE2
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
This study looks at combining special radiation treatments and new medicines for advanced liver cancer before a transplant. It aims to see how many people can have a successful transplant and how well they do afterwards.
Canada - not yet recruitingNA
Community Screening and Management of Hepatitis B, C and Delta in the Mongolian Population Living in France
This study aims to find and help people from Mongolia living in France who have hepatitis B, C, or Delta. These liver conditions are common in Mongolia and can lead to serious health problems like liver cancer if not treated. The study will offer screening and set up care for those who need it.
France - recruitingNA
Amplitude-modulated Radiofrequency Electromagnetic Field Treatment for Advanced Hepatocellular Carcinoma (Immune-RF)
This study is looking into a new way to treat advanced liver cancer by combining two established immune-boosting medications with a special type of low-energy radio wave treatment. It aims to see how well this combined approach works and if it's safe.
Germany - recruiting
Multiparametric MRI for Characterization of Hepatocellular Carcinoma
This study uses advanced MRI scans to get a better look at liver cancer (HCC). Researchers want to see if these detailed scans can help doctors understand the cancer more clearly and plan the best treatments, like TACE or SIRT, for people in Germany.
Germany - not yet recruitingNA
International Study on Treatment of Liver (HCC) Patients With IRE
This study looks at a new treatment called irreversible electroporation (IRE) for people with a common type of liver cancer, hepatocellular carcinoma (HCC). It aims to collect information on how well the treatment works and how safe it is for patients with liver tumours.
United Kingdom