HORMONE RECEPTOR-POSITIVE research hub
5 indexed studies · 3 currently recruiting
- ongoing, recruitingTherapeutic exploratory (Phase II)
C4391025_AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER, PHASE 2 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO LETROZOLE ALONE IN POSTMENOPAUSAL WOMEN 18 YEARS OR OLDER WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE BREAST CANCER IN THE NEOADJUVANT SETTING
This study is looking at a new medicine (PF-07220060) combined with a standard breast cancer drug (Letrozole). It's for women after menopause with a specific type of breast cancer, to see if the combination helps shrink the cancer before surgery. We want to know how well it works and if it's safe.
Italy · Spain · France - recruitingPHASE3
Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.
This study is for people with advanced ER+/HER2- breast cancer with an ESR1 gene change, whose cancer has grown despite previous treatments. It tests a new drug called elacestrant alongside an existing one, everolimus, to see if this combination works better at stopping the cancer from growing.
Austria · Brazil · Czechia - recruitingPHASE2
A Trial of Early Detection of Molecular Relapse With Circulating Tumour DNA Tracking and Treatment With Palbociclib Plus Fulvestrant Versus Standard Endocrine Therapy in Patients With ER Positive HER2 Negative Breast Cancer
This study looks for tiny traces of cancer DNA in the blood to find early signs of breast cancer coming back. If found, it tests if a new treatment combination (Palbociclib and Fulvestrant) works better than standard treatment for ER-positive, HER2-negative breast cancer.
France · United Kingdom - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - authorisedTherapeutic exploratory (Phase II)
Prevention of Ribociclib-related hepatotoxicity in breast cancer patients: a phase II, multicentre, open label, single arm trial of Silimarin.
This study looks at whether a natural product called Silymarin can help protect the liver of breast cancer patients taking a medicine called Ribociclib. It aims to see if Silymarin can reduce liver side effects, comparing it to what we know from past studies.
Italy