High grade glioma research hub

A Phase 1 Single Center Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy

This study is looking at a new treatment for a type of brain tumour called high-grade glioma. It combines a special light-sensitive medicine with ultrasound. Researchers want to see how safe this treatment is before surgery and standard care.

Study of Olutasidenib and Temozolomide in HGG

This study is for young people aged 12-39 with a type of brain tumour called high-grade glioma (HGG) that has a specific IDH1 gene change. It tests if a new drug, olutasidenib, combined with standard treatment, can help patients live longer after radiotherapy.

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

This study is looking at new drug combinations to treat certain types of brain tumours in children and young adults. It aims to see if combining ribociclib with either everolimus or temozolomide can help patients live longer and improve their health.

Targeted Pediatric High-Grade Glioma Therapy

This study aims to understand childhood brain tumours better by looking at their genes. For children, teenagers, and young adults with newly diagnosed high-grade gliomas, including DIPG, doctors will check their tumour's genetic makeup to see if they might be suitable for specific new treatments in future trials.

An open randomized phase II clinical trial evaluating the safety and efficacy of rapamycin in the treatment of gliomas high-grade malignant gliomas in children as part of the establishment management of rare and ultra rare diseases of the central nervous system associated with mTOR pathway activation: BraimTOR- ONKO

This study is testing a medicine called Rapamune for children with a serious type of brain tumour. Doctors want to see how safe the medicine is and if it helps children live longer or if their tumour gets smaller. It's a key step in finding better treatments for rare conditions.

Phase I/II multicenter study to assess efficacy and safety of ribociclib (LEE011) in combination with topotecan and temozolomide (TOTEM) in pediatric patients with relapsed or refractory neuroblastoma and other solid tumors