Atherosclerotic Cardiovascular Disease research hub
14 indexed studies · 5 currently recruiting
- enrolling by invitation
Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular Disease
This study is following people who've had an experimental gene therapy for certain heart conditions. It checks how the treatment affects them over a long time, up to 15 years, looking for any lasting benefits or side effects to make sure it's safe and works well.
New Zealand · United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of rosuvastatin.
This study is looking at two versions of a common cholesterol-lowering medicine called rosuvastatin to see if they work the same way in the body. If you have high cholesterol, you might be able to take part if you're an adult. It's a medical study to help ensure medicines are effective and safe.
Spain - recruitingNA
PET Imaging of Inflammation and Lipid Lowering Study
This study looks at new ways to scan and treat high cholesterol and hardened arteries. It uses special scans and medications like Inclisiran or Colchicine to see how they affect swelling in the arteries. We hope to find better ways to understand and treat these conditions.
United Kingdom - recruitingPHASE1
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
This study is testing a new treatment, VERVE-201, for people with very high cholesterol and fats in their blood that haven't responded to other medicines. Scientists want to see if it's safe and how it affects these blood fats by altering a specific gene in the liver.
United States · Australia · Canada - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of MK-0616 Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia
This study is testing a new medicine, MK-0616, to see if it can help lower high cholesterol as well as or better than existing treatments. We're looking at how much 'bad' cholesterol (LDL-C) goes down and if the new medicine is safe for people with high cholesterol.
Spain · France - active not recruitingPHASE3
Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension
This study is looking into the long-term safety and effectiveness of a new medication called Enlicitide Decanoate. It's for adults with high cholesterol who have already taken part in previous studies of this drug. The aim is to see how well it works and if it's safe over a longer period.
United States · Argentina · Australia - recruitingNA
Effects of a Digital Health Application (Lipodia) on LDL-cholesterol Levels
This study looks at whether a digital health app called Lipodia can help adults with high cholesterol lower their "bad" cholesterol levels. Researchers will compare people using the app with those who only have their usual care.
Germany - recruitingNA
Role of A2A Receptor in Hypercholesterolemic Patients
This study looks at how high cholesterol affects the body's natural defences and blood vessel health. Researchers want to understand if a specific molecule, the A2A receptor, changes in people with high cholesterol and if current treatments help. It could lead to better ways to prevent heart problems.
France - active not recruiting
Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia
This study looks at how a medicine called bempedoic acid (alone or with ezetimibe) works in real life for people with high cholesterol. It checks its effects on cholesterol levels, heart health, and any side effects over time.
Austria · Belgium · Germany - active not recruitingNA
WB-EMS Effects on Cardiometabolic Risk Factors
This study looks at how a type of exercise called whole-body electrical stimulation (WB-EMS) affects blood pressure and other health factors in men over 50. It wants to see if this quick, joint-friendly exercise can help people with slightly high blood pressure.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-0616 in Adults With Hypercholesterolemia
This study is looking at a new medicine, MK-0616, for adults with high cholesterol. It compares the new medicine to a dummy pill to see if it lowers 'bad' cholesterol and how safe it is over 24 weeks. This helps us understand if MK-0616 could be a new treatment option.
Italy · Spain · Germany - ongoing, recruitingTherapeutic use (Phase IV)
A randomized, multicenter, open-label trial comparing the effectiveness of Inclisiran to bempedoic acid on LDL cholesterol (LDL-C) lowering in participants with atherosclerotic cardiovascular disease (VICTORION-CHALLENGE)
This study, called VICTORION-CHALLENGE, is comparing two medicines, Inclisiran and Bempedoic acid, to see which one is better at lowering 'bad' cholesterol (LDL-C) in people who have had heart or circulation problems. We want to find out how much they can reduce cholesterol after about five months.
Germany - ongoing, recruitingTherapeutic use (Phase IV)
Efficacy, safety, tolerability and quality of life of ongoing individually optimized lipid-lowering therapy with or without inclisiran (KJX839) – a randomized, placebo-controlled, double-blind multicenter phase IV study in participants with hypercholesterolemia
This study is looking at a new way to lower 'bad' cholesterol (hypercholesterolemia). It compares a new medicine called Inclisiran with usual treatments, to see if it's safe and helps people feel better and reach their cholesterol goals.
Bulgaria · Poland · France - ongoing, recruitingHuman Pharmacology (Phase I)- Other
MK-7091 Formulations Study in Healthy Adult Participants
This study is testing different versions of a new medicine, MK-7091, in healthy adults. It's looking at how the body handles this medicine, which might eventually help people with high cholesterol. It's an early-stage study.
Belgium