- active not recruitingPHASE1, PHASE2
A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines
This study is testing two new vaccines for malaria, RH5.1 and RH5.2-VLP, to see if they are safe and effective. Researchers will give healthy volunteers the vaccines and then expose some to malaria to see if the vaccines protect them. This is a crucial step towards preventing this serious disease.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A single-dose, open-label, randomized, two-period, two-sequence, crossover pivotal bioequivalence study on Taromentin® 500 mg + 125 mg film-coated tablets versus Augmentin® 500 mg + 125 mg film-coated tablets in healthy volunteers under fed conditions.
This study compares two very similar medicines, Taromentin and Augmentin, which are both used for infections. We want to see if they work the same way in healthy adults after they’ve eaten. It’s a small study to make sure the new medicine, Taromentin, is just as good.
Czechia - recruiting
Collection of Blood Samples for New Diagnostic Devices 2
This study helps develop new tests for conditions like blood clots, heart problems, kidney issues, and infections. It involves giving blood samples (from a vein or finger-prick) to help create quick, accurate tests that can be used at clinics, offering faster results to improve patient care.
United Kingdom - recruitingNA
Description of the Immune Response to Yellow Fever Vaccination
This study looks at how the yellow fever vaccine makes our immune system stronger. It explores a new idea called 'trained immunity' where some vaccines might protect us from other infections, not just the one they’re designed for. We're studying how people respond to these vaccines.
France - recruitingPHASE2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
This study is testing a new medicine, Rhu-pGSN, for people with severe breathing problems (ARDS) caused by infections. It will compare the new medicine to a dummy treatment (placebo) to see if it's safe and helps people recover better.
United States · Belgium · Bulgaria - not yet recruitingNA
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
This study looks at how certain antibiotics, called beta-lactams, work in very sick patients on a special life support machine called VA-ECMO. Doctors want to find the best way to give these antibiotics to help fight infections effectively.
France - recruiting
X-linked Moesin Associated Immunodeficiency
This study looks at X-linked Moesin Associated Immunodeficiency (X-MAID), a rare condition affecting the immune system. Researchers are gathering information from patients worldwide to better understand how to diagnose and treat this illness, aiming to create clearer guidelines for doctors.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A single-dose, open-label, randomized, two-period, two-sequence, crossover pivotal bioequivalence study on two amoxicillin-clavulanic acid film-coated tablet formulations in healthy volunteers under fed conditions.
This study looks at a new version of an antibiotic called amoxicillin-clavulanic acid, usually used for infections. We want to see if the new tablet works in the same way as the original when taken with food. Healthy adults are taking part.
Czechia - active not recruitingPHASE1
A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
This study is testing a new malaria vaccine called RH5.1. We want to see how safe it is and how well it helps the body fight malaria. Two different ways of giving the vaccine are being compared to find the best way.
United Kingdom - recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
This study is looking at how well Exactech shoulder replacements work over a long time. It will follow people who have had this surgery to understand its safety and effectiveness for conditions like arthritis and rotator cuff tears, for at least 10 years.
United States · Canada · France