Gastro-Intestinal Disorder research hub

NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study

This study compares body markers linked to inflammation in people with Crohn's disease or ulcerative colitis (IBD) and healthy individuals. It aims to understand IBD better and find ways to predict treatment responses, ultimately leading to improved care.

FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis

The FARGO trial is investigating if a 'healthy gut bacteria transplant' (Faecal Microbiota Transplant, or FMT) can help people in the UK with the liver condition Primary Sclerosing Cholangitis (PSC) who also have Inflammatory Bowel Disease (IBD). Half of the participants will receive FMT, and the other half a dummy treatment, to see if it improves their condition.

PIBD-SETQuality: the Inception Cohort and Safety Registry

This study looks at how well current treatments work and their safety for children and teenagers with Inflammatory Bowel Disease (IBD). It wants to understand how individual factors might affect treatment outcomes and serious complications.

Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.

Trial of Mirtazapine for Depression in IBD

Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study

This study looks at using robotic surgery for inflammatory bowel disease (IBD) like Crohn's disease and ulcerative colitis. Researchers want to see if robots can help surgeons operate more effectively and how this new method compares to traditional keyhole surgery for IBD.

Nutrition and Clinical Outcomes in IBD

This study looks at how nutrition and body health affect people with Crohn's disease and ulcerative colitis. We want to find better ways to check for poor nutrition and understand how it impacts treatment, surgery, and overall well-being in IBD patients.

Mechanism of Chronic Pain in Patients With IBD

This study looks into why some people with Inflammatory Bowel Disease (IBD) still get tummy pain even when their IBD is settled. Researchers want to find out what factors, including body and mind, might contribute to this ongoing pain.

ACTIVE-IBD Study: Physical Activity and Sleep in Paediatric Inflammatory Bowel Disease

This study looks at how active children and teenagers with Inflammatory Bowel Disease (IBD) are. We're using questionnaires and special wrist trackers to understand their activity levels and how they might link to their health.

IBDminds - Mapping the Influence of aNxiety and DepreSsion on IBD

This study, IBDminds, explores how anxiety and depression affect treatment success for Inflammatory Bowel Disease (IBD). We're asking people with IBD taking advanced treatments to complete questionnaires to see if their mental health impacts how well their medication works over time.

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.

West Hertfordshire Inflammatory Bowel Disease Technology Study

This study looks at how we diagnose and monitor Inflammatory Bowel Disease (IBD). We're exploring new ways to measure IBD using information from existing tests. The goal is to improve how we track these conditions and help doctors make more accurate decisions for patients.

Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis