Knee osteoarthritis research hub

A Phase 1/2a Randomized, Double-Blind Placebo-controlled Study of Intra-articular Allocetra in Knee Osteoarthritis

This study is looking at a new treatment called Allocetra for knee osteoarthritis. We want to see how safe it is and if it helps reduce knee pain and improve daily activities for people with this condition.

A randomized, two-arm, placebo-controlled, participant, investigator and sponsor-blinded, proof-of-concept study investigating the efficacy, safety and tolerability of QUC398 in patients with symptomatic knee osteoarthritis

This study is testing a new medicine, QUC398, for people with knee osteoarthritis. We want to see if it helps reduce pain and is safe to use. Patients will receive either QUC398 or a dummy treatment, along with standard pain relief.

A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis

This study is testing a new combination medicine (APPA) for knee osteoarthritis. Researchers want to see if APPA can reduce knee pain better than a dummy treatment or a common painkiller like Panodil. They will mostly look at how much pain changes over 12 weeks.

Randomized control trial comparison between intra-articular infiltrations of PRP, MFAT, and PRP-MFAT in the treatment of symptomatic knee osteoarthritis.

This study is looking into new ways to treat knee osteoarthritis. Researchers are comparing injections of different natural substances, like PRP and MFAT, to see which works best to reduce pain and improve movement in people with knee problems.

A randomized, two-arm, placebo-controlled, participant and investigator-blinded study investigating the efficacy, safety and tolerability of DFV890 in patients with symptomatic knee osteoarthritis

This study is looking into a new medicine, DFV890, for people with knee osteoarthritis. It compares DFV890 to a dummy treatment (placebo) to see if it helps with pain and is safe to use.

A prospective, double-blinded, randomized, placebo-controlled phase 1/2a study to assess safety, tolerability, systemic exposure and preliminary efficacy of single intraarticular injections of three dose levels of SYN321 and placebo in patients with symptomatic knee osteoarthritis

This study is testing a new medicine, SYN321, for knee osteoarthritis. It's looking at how safe it is, how well people tolerate it, and if it helps with pain, compared to a dummy treatment. We hope to find out if it's a good option for future treatments.

The effects of 2-week long treatment with naproxen sodium (Nalgesin® Forte) on synovial fluid cytokine and naproxen concentration and clinical outcomes in patients with knee osteoarthritis – ZOOM-IN: A randomized, double-blind, placebo-controlled, parallel, multicenter clinical trial

This study is looking at how a pain relief medicine called naproxen (Nalgesin Forte) affects knee osteoarthritis over two weeks. Researchers are checking how it reduces inflammation and improves symptoms compared to a dummy pill (placebo).

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of PPV-06 Active Immunotherapy in Patients with Inflammatory Knee Osteoarthritis (KOA).

This study is testing a new treatment, PPV-06, for knee osteoarthritis. It aims to see if this treatment can reduce pain and improve movement compared to a dummy treatment, called a placebo, over 54 weeks.

GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)

This study compares two treatments for knee pain caused by osteoarthritis: a new procedure (GAE using tiny spheres) and standard steroid injections. Researchers want to see which works best over two years for people with ongoing knee pain.

Return to Golf After Orthopaedic Surgery

This study looks at how many golfers return to playing golf after having hip, knee, or shoulder replacement surgery. Researchers will follow their progress for a year to understand this process better.

Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis

This study compares standard knee replacement surgery with a new robotic-assisted method for knee arthritis. It aims to see if the robotic approach leads to better pain relief, function, and patient satisfaction, and if it's safer and more efficient.

Observational Clinical Investigation of Arthrosamid in Knee Osteoarthritis

This study looks at how a treatment called Arthrosamid® works for people with knee osteoarthritis over five years. It's for adults already receiving this treatment, checking their progress with calls and occasional visits to understand its long-term effects.

Genicular Artery Embolisation for Knee Osteoarthritis II

This study looks at a new treatment called Genicular Artery Embolisation (GAE) for knee osteoarthritis pain that hasn't improved with other treatments. It compares GAE to a dummy procedure to see if it helps reduce pain in your knee. Participants will be followed for up to 24 months.

Golf After Orthopaedic Surgery: A Longitudinal Follow-up (GOLF) Study

This study looks at how many golfers can return to their sport after hip, knee, or shoulder replacement surgery. It also checks when they can play again, how well they play, and their overall health and joint recovery.

Sensor-based Physiotherapy Intervention With Virtual Reality

This study explores if a special virtual reality (VR) physiotherapy program can help people with knee pain from osteoarthritis. It compares home-based VR exercises to standard physiotherapy to see if the VR system is practical and helpful for patients.

Uncemented Tritanium TKR vs Cemented Triathlon TKR

This study is looking at two types of knee replacement surgery to see if one protects bone density around the new knee better than the other. We want to find out if the way the new knee is attached (with or without cement) affects how strong your bone stays around it.

Dietary Supplementation With Blueberry in OA

This study looks at how blueberry supplements might help people with knee osteoarthritis scheduled for knee replacement surgery. We want to see if blueberries can reduce joint inflammation, improve symptoms, and help with recovery after surgery, exploring their potential beyond just symptom relief.

Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement

This study looks at how people with knee arthritis walk and move, both before and after knee replacement surgery, compared to healthy people. We want to understand why some people still struggle with activity after surgery, hoping to find better ways to help them.

IMProving Outcomes With ACT After Knee Surgery

This study looks at a special type of therapy called Acceptance and Commitment Therapy (ACT) before knee replacement surgery. It aims to see if ACT can help people who are at higher risk of not doing as well after their surgery, especially if they feel down or worried.

A Randomized, Double-Blind, Multi-Center, Placebo-Controlled, Trial to Evaluate the Efficacy and Safety of Once Daily Diclofenac Gel AMZ001 3.06% in the Treatment of Pain and Symptoms of Knee Osteoarthritis

This study is testing a new gel (AMZ001) for knee osteoarthritis pain. Doctors want to see if it works better than a dummy gel and how safe it is. It's a key stage before the gel potentially becomes widely available.

Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial

This study compares different pain relief methods after knee replacement surgery for osteoarthritis. It looks at how well various nerve blocks work to control pain, focusing on pain levels, how much pain medication is needed, and how quickly patients recover after the operation.

Gait in Fixed Or Rotating Cementless Total Knee Arthroplasties

This study compares two common knee replacement implants, Attune and Triathlon, which are designed to help people with painful knee arthritis. Researchers want to see if one implant helps patients walk better and feel more stable after surgery.

First-in-human study to assess the safety and feasibility of intra-articular administration of allogeneic engineered gingival fibroblasts (aeGF) in participants with knee osteoarthritis.

This early-stage study is looking at a new treatment for knee osteoarthritis. Researchers want to see if injecting special cells (gingival fibroblasts) into the knee is safe and possible. This is the very first time this treatment is being tried in people.

Safety, tolerability and pharmacokinetics of intra‐articular (IA) single ascending dose of 4P‐004 in patient with Kellgren and Lawrence grade 2 to 4 osteoarthritic (OA) knee

A randomized, placebo controlled, investigator and participant-blinded study, investigating safety, tolerability and efficacy of RHH646 in participants with knee osteoarthritis