- authorisedPhase III and phase IV (Integrated)
ALBUMINUS: Dose reduction of human albumin during large-volume paracentesis in patients with cirrhosis
This study is for adults with liver cirrhosis who need fluid drained from their tummy. Normally, patients receive a protein drip called albumin to protect their kidneys during this procedure. Researchers want to find out if using a lower dose of albumin is safe and works just as well as the standard dose.
Netherlands - recruiting
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
This study looks at how well different methods of machine-preserving donor livers work for liver transplants in Europe. It aims to create new standards to show the best results we can expect with these modern techniques.
Austria · Belgium · France - recruiting
Freiburg TIPS Registry
This study in Germany looks at people with serious liver conditions needing a special treatment called TIPS. Researchers want to see how well TIPS works and how it affects patients' health over time. They collect information and blood samples to learn more.
Germany - recruitingNA
Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcifications
This study looks at how liver problems, especially scarring, might affect the hardening of arteries. Researchers want to see if liver transplants can help by bringing a natural body chemical back to normal levels, potentially slowing down artery changes. They'll use blood and urine tests.
France - recruiting
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
This study looks at how well people with severe liver disease (ACLF) do after a liver transplant compared to those with less severe liver disease. It also checks why some people with ACLF don't get a transplant and how they fare.
United States · Argentina · Australia - active not recruiting
naVIGation Invitations Liver surveillANce upTake
This study looks at new ways to help people attend vital liver scans for conditions like liver scarring or hepatitis B. It explores if special invitations and support from a Patient Navigator can improve attendance and lead to earlier cancer detection.
United Kingdom - enrolling by invitationNA
The Impact of a Dietary Fiber Enriched Diet on the Outcome of Patients with Liver Cirrhosis
This study looks at how a diet rich in fibre might help people with liver scarring (cirrhosis). We're trying to see if increasing fibre, or using a fibre substitute, can improve gut health, reduce body-wide inflammation, and prevent problems linked to cirrhosis.
Germany - recruiting
Influence of Sarcopenia on the Course of the Diseases
This study looks at how muscle weakness, called sarcopenia, affects people with serious illnesses like cancer or liver problems. We're using simple ultrasound scans and blood tests to find better ways to spot sarcopenia early and understand its impact on a patient's health journey.
Germany - recruiting
Exploration of Systemic and Portal Hemostasis in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Placement
This study aims to understand why some people with liver scarring (cirrhosis) develop blood clots in a major liver blood vessel, called the portal vein. Researchers are looking at blood samples taken during a procedure called a TIPS to see how blood clotting and inflammation differ in the liver and the rest of the body.
France - recruitingPHASE2
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
This study is looking at a new combination treatment for people with severe liver disease (cirrhosis) who have recently been in hospital. We want to see if combining two existing medicines, albumin and enoxaparin, is safe and helps improve outcomes after leaving the hospital.
France · Germany · Italy - authorisedHuman Pharmacology (Phase I)- First administration to humans
A study to evaluate the safety and tolerability of single ascending doses of AGMB-101 in healthy participants (Part A) and patients with liver cirrhosis (Part B).
This study is looking at a new medicine called AGMB-101. It wants to see how safe it is and how well people tolerate it. First, healthy volunteers will try different doses. Then, people with a liver problem called cirrhosis will also try it. This is an early stage of testing new medicines.
Belgium - recruiting
Validation of New Prognostic Biomarkers in Patients With Decompensated Cirrhosis
This study looks for new ways to predict how well people with severe liver cirrhosis will recover after a hospital stay. Researchers are using body markers to better understand the disease and help doctors give more personalised care to improve patient outcomes.
France · Germany · Italy - active not recruiting
Study in Patients With Decompensated Liver Cirrhosis
This study looks at people with liver scarring (cirrhosis) who have recently had a serious liver problem. We want to understand how their illness progresses over time, using information from their regular doctor visits, to help develop better future treatments.
Spain · United Kingdom - recruitingPHASE3
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
The PROMISE trial is testing a new capsule treatment for people with liver scarring (cirrhosis), particularly those whose condition is linked to alcohol or fatty liver disease. These capsules contain healthy gut bacteria from donors and aim to reduce serious infections.
United Kingdom - recruitingNA
Real-world Elecsys® GAAD Implementation and Validation to Improve Surveillance and Early Detection of HCC
This study looks at a new test called Elecsys® GAAD to help doctors find liver cancer (hepatocellular carcinoma) earlier in people with liver scarring (cirrhosis). The aim is to see if this new test can improve current screening methods and help patients get treatment sooner.
United Kingdom - recruiting
A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions
This study is testing a simple breath-test to find liver cancer earlier and check on other liver conditions. It looks for tiny chemicals in your breath. You could join if you have liver cancer, cirrhosis, or certain other liver issues, or tummy problems with a normal liver scan.
United Kingdom - recruitingNA
A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.
This study is testing a new 'liver dialysis' device called DIALIVE 2.0 for people with serious liver failure. It aims to see if adding this treatment to usual care helps patients more. We're looking for 72 people in the UK with worsening liver cirrhosis to take part.
United Kingdom