- ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind Study of Ociperlimab, an Anti-TIGIT Antibody, in Combination With Tislelizumab Compared to Pembrolizumab in Patients With Previously Untreated, PD-L1-Selected, and Locally Advanced, Unresectable, or Metastatic Non-Small Cell Lung Cancer
This study is testing a new combination of drugs, ociperlimab and tislelizumab, against a standard treatment, pembrolizumab, for a serious type of lung cancer. The aim is to see if the new combination can help people live longer and improve their quality of life.
Poland · France · Spain - recruitingNA
Early Feasibility Clinical Investigation to Assess YntraDose™ as a Neoadjuvant Treatment for LA-PDAC
This study investigates a new radiotherapy for advanced pancreatic cancer that can't be surgically removed. It involves a single injection of a radioactive implant directly into the tumour, alongside standard chemotherapy. Researchers will assess safety, effectiveness, and impact on quality of life.
Italy · United Kingdom - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France