Locally Advanced or Metastatic Solid Tumors research hub

An Open-label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination with Atezolizumab in Patients with Locally Advanced or Metastatic Solid Tumors

This study is testing a new medicine called XmAb24306, both on its own and with another drug, atezolizumab. It's for adults with advanced or metastatic solid tumors. Scientists are looking at how safe it is and what dose works best.

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Inavolisib in Combination with Paclitaxel in Patients with Locally Advanced or Metastatic Solid Tumors

This study is looking at a new medicine called Inavolisib, given with Paclitaxel, for people with advanced solid cancers. It aims to see if the treatment is safe, how the body handles it, and if it can help shrink tumours.

A Phase 1 Study of TAS0612 in Patients with Locally Advanced or Metastatic Solid Tumors

This study is looking for people with advanced solid cancers that have spread. It's testing a new medicine called TAS0612 for the very first time in humans. The main goal is to see if the medicine is safe and what dose can be given, rather than to treat the cancer directly.

A Phase I/II, First-In-Human, Multi-Part, Open-Label, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF1001 in Patients With Locally Advanced or Metastatic Solid Tumors, and Expansion in Selected Indications

This study is testing a new treatment, DF1001, for advanced or spreading cancers. It will look at how safe the treatment is, what side effects it causes, and how it affects the body. Researchers also want to see if it can help shrink tumours or stop them from growing.

Study of XB010 in Subjects With Solid Tumors

This study is testing a new medicine called XB010, both on its own and with another drug (pembrolizumab), for people with certain advanced solid cancers. It aims to see how safe it is, how well the body handles it, and if it helps shrink tumours when other treatments haven't worked.

A study evaluating the safety, tolerability, pharmacokinetics, and activity of RO7566802 given alone and in combination with atezolizumab in patients with locally advanced or metastatic solid tumor malignancies

This study is looking at a new medicine, RO7566802, both by itself and with another drug called atezolizumab. It's for adults with advanced or spreading solid cancers. The main goals are to check if it's safe, how the body handles it, and if it shows signs of helping.

A Study to Investigate the Safety and Effectiveness of RO7759065 in Combination with Atezolizumab in Participants with Locally Advanced or Metastatic Cancer

This study is looking at a new medicine, RO7759065, combined with an existing cancer drug, atezolizumab. It's for adults with advanced cancer that has spread. Researchers want to see if this combination is safe and how well it works to treat different types of solid tumours.

A Phase 1/2, Multicenter, Open-label, Dose-escalation, and Dose-expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamic, and Antitumor Activity of CR-001 in Adult Participants with Locally Advanced or Metastatic Solid Tumors.

This study is testing a new medicine, CR-001, for adults with certain advanced or spreading cancers. It aims to find a safe and effective dose, understand how the body uses the medicine, and see if it can shrink tumors or slow their growth.

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination with a Checkpoint Inhibitor with or without Standard-of-Care Chemotherapy in Patients with Locally Advanced or Metastatic Solid Tumors